Target Description

Type Detail
Target ID T82W6S
Protein Name Toll-like receptor 3
Uniprot ID O15455
Protein Name Alias CD antigen CD283
Gene ID 7098
Gene Symbol TLR3
Gene Alias NA
TTD T67894: Clinical Trial target
Pfam PF01582 ; PF13516 ; PF13855 ; PF17968
GO
0007250:activation of NF-kappaB-inducing kinase activity

0035690:cellular response to drug

0031012:extracellular matrix

0043331:response to dsRNA

0097191:extrinsic apoptotic signaling pathway

0005789:endoplasmic reticulum membrane

0005615:extracellular space

0006972:hyperosmotic response

0007252:I-kappaB phosphorylation

0070266:necroptotic process

0097190:apoptotic signaling pathway

1901224:positive regulation of NIK/NF-kappaB signaling

0032755:positive regulation of interleukin-6 production

0009597:detection of virus

0051607:defense response to virus

0038023:signaling receptor activity

0045671:negative regulation of osteoclast differentiation

0016020:membrane

0032722:positive regulation of chemokine production

0034138:toll-like receptor 3 signaling pathway

0032760:positive regulation of tumor necrosis factor production

0001774:microglial cell activation

0032757:positive regulation of interleukin-8 production

0071260:cellular response to mechanical stimulus

0032728:positive regulation of interferon-beta production

0035666:TRIF-dependent toll-like receptor signaling pathway

0071346:cellular response to interferon-gamma

0042742:defense response to bacterium

0043065:positive regulation of apoptotic process

0042802:identical protein binding

0032729:positive regulation of interferon-gamma production

0002730:regulation of dendritic cell cytokine production

0005765:lysosomal membrane

0005737:cytoplasm

0045087:innate immune response

0034128:negative regulation of MyD88-independent toll-like receptor signaling pathway

0003725:double-stranded RNA binding

0005887:integral component of plasma membrane

0046330:positive regulation of JNK cascade

0007249:I-kappaB kinase/NF-kappaB signaling

0097527:necroptotic signaling pathway

0032727:positive regulation of interferon-alpha production

0045944:positive regulation of transcription by RNA polymerase II

0043330:response to exogenous dsRNA

0045766:positive regulation of angiogenesis

0050729:positive regulation of inflammatory response

0071360:cellular response to exogenous dsRNA

0010008:endosome membrane

0002224:toll-like receptor signaling pathway

0008584:male gonad development

0004888:transmembrane signaling receptor activity

0034346:positive regulation of type III interferon production

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0036020:endolysosome membrane

0010628:positive regulation of gene expression

0005769:early endosome

0006954:inflammatory response

0034123:positive regulation of toll-like receptor signaling pathway

0000139:Golgi membrane

0051092:positive regulation of NF-kappaB transcription factor activity

0007165:signal transduction

0035458:cellular response to interferon-beta

0032735:positive regulation of interleukin-12 production

0002756:MyD88-independent toll-like receptor signaling pathway

PDB 1ZIW ; 7C76 ; 2A0Z ; 3ULV ; 2MK9 ; 2MKA ; 3ULU ; 5GS0
Drugbank NA
KEGG hsa:7098

Related Compounds  (Total: 2)

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C0325
Name: Progesterone
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C1261
Name: Cpg


Related Herbs  (Total: 8)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum