Target Description

Type Detail
Target ID T18SKL
Protein Name C-C motif chemokine 5
Uniprot ID P13501
Protein Name Alias EoCP;  Eosinophil chemotactic cytokine;  SIS-delta;  Small-inducible cytokine A5;  T cell-specific protein P228;  TCP228;  T-cell-specific protein RANTES
Gene ID 6352
Gene Symbol CCL5
Gene Alias D17S136E;  SCYA5
TTD T16263: Clinical Trial target
Pfam PF00048
GO
0002548:monocyte chemotaxis

0033634:positive regulation of cell-cell adhesion mediated by integrin

0031726:CCR1 chemokine receptor binding

0031663:lipopolysaccharide-mediated signaling pathway

0042102:positive regulation of T cell proliferation

0043922:negative regulation by host of viral transcription

0007186:G protein-coupled receptor signaling pathway

0042379:chemokine receptor binding

0071346:cellular response to interferon-gamma

0046817:chemokine receptor antagonist activity

0010759:positive regulation of macrophage chemotaxis

0031730:CCR5 chemokine receptor binding

2000406:positive regulation of T cell migration

0042803:protein homodimerization activity

0016004:phospholipase activator activity

0019221:cytokine-mediated signaling pathway

0006874:cellular calcium ion homeostasis

0004435:phosphatidylinositol phospholipase C activity

0006935:chemotaxis

0030593:neutrophil chemotaxis

0042327:positive regulation of phosphorylation

0042056:chemoattractant activity

0070098:chemokine-mediated signaling pathway

0014911:positive regulation of smooth muscle cell migration

0090026:positive regulation of monocyte chemotaxis

0044344:cellular response to fibroblast growth factor stimulus

0043547:positive regulation of GTPase activity

0070233:negative regulation of T cell apoptotic process

0031328:positive regulation of cellular biosynthetic process

1901214:regulation of neuron death

0030298:receptor signaling protein tyrosine kinase activator activity

0042802:identical protein binding

0045089:positive regulation of innate immune response

0050796:regulation of insulin secretion

0070234:positive regulation of T cell apoptotic process

0048245:eosinophil chemotaxis

0009615:response to virus

0004672:protein kinase activity

0031729:CCR4 chemokine receptor binding

0045071:negative regulation of viral genome replication

0002676:regulation of chronic inflammatory response

0006887:exocytosis

0000165:MAPK cascade

0043491:protein kinase B signaling

0048247:lymphocyte chemotaxis

0006816:calcium ion transport

0071407:cellular response to organic cyclic compound

0048661:positive regulation of smooth muscle cell proliferation

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0045070:positive regulation of viral genome replication

0045744:negative regulation of G protein-coupled receptor signaling pathway

2000503:positive regulation of natural killer cell chemotaxis

0031584:activation of phospholipase D activity

0071356:cellular response to tumor necrosis factor

0006954:inflammatory response

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0046427:positive regulation of receptor signaling pathway via JAK-STAT

0043621:protein self-association

0048020:CCR chemokine receptor binding

0010820:positive regulation of T cell chemotaxis

0009636:response to toxic substance

0005615:extracellular space

0034112:positive regulation of homotypic cell-cell adhesion

0045785:positive regulation of cell adhesion

0048246:macrophage chemotaxis

0051928:positive regulation of calcium ion transport

0007159:leukocyte cell-cell adhesion

0002407:dendritic cell chemotaxis

0007267:cell-cell signaling

0008009:chemokine activity

0071347:cellular response to interleukin-1

0045948:positive regulation of translational initiation

0030335:positive regulation of cell migration

0010536:positive regulation of activation of Janus kinase activity

0070374:positive regulation of ERK1 and ERK2 cascade

0005576:extracellular region

0042119:neutrophil activation

0050863:regulation of T cell activation

PDB 1U4L ; 1U4M ; 5DNF ; 2L9H ; 6STK ; 6C6D ; 1U4R ; 5UIW ; 1RTN ; 6LOG ; 1RTO ; 5CMD ; 6FGP ; 2VXW ; 1B3A ; 1HRJ ; 5COY ; 5L2U ; 1EQT ; 1U4P ; 6AEZ
Drugbank DB02322 ; DB02353
KEGG hsa:6352

Related Compounds  (Total: 4)

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C0325
Name: Progesterone
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C0660
Name: Neferine
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C0949
Name: indirubin
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C1106
Name: shikonin


Related Herbs  (Total: 9)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum