Target Description

Type Detail
Target ID T21XA6
Protein Name Leukemia inhibitory factor
Uniprot ID P15018
Protein Name Alias LIF;  Differentiation-stimulating factor;  D factor;  Melanoma-derived LPL inhibitor;  MLPLI;  Emfilermin
Gene ID 3976
Gene Symbol LIF
Gene Alias HILDA
TTD T29774: Clinical Trial target
Pfam PF01291
GO
0043410:positive regulation of MAPK cascade

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0072307:regulation of metanephric nephron tubule epithelial cell differentiation

0048863:stem cell differentiation

0005615:extracellular space

0048711:positive regulation of astrocyte differentiation

0007566:embryo implantation

0033138:positive regulation of peptidyl-serine phosphorylation

0001974:blood vessel remodeling

0045835:negative regulation of meiotic nuclear division

0005146:leukemia inhibitory factor receptor binding

0045651:positive regulation of macrophage differentiation

0005102:signaling receptor binding

0007275:multicellular organism development

0005829:cytosol

0070373:negative regulation of ERK1 and ERK2 cascade

0060463:lung lobe morphogenesis

0005576:extracellular region

0008083:growth factor activity

0060707:trophoblast giant cell differentiation

0033141:positive regulation of peptidyl-serine phosphorylation of STAT protein

0060708:spongiotrophoblast differentiation

0046888:negative regulation of hormone secretion

0060426:lung vasculature development

0046697:decidualization

0045595:regulation of cell differentiation

0005125:cytokine activity

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0048644:muscle organ morphogenesis

0045944:positive regulation of transcription by RNA polymerase II

0019827:stem cell population maintenance

0007260:tyrosine phosphorylation of STAT protein

0006955:immune response

0008284:positive regulation of cell population proliferation

0019221:cytokine-mediated signaling pathway

0048861:leukemia inhibitory factor signaling pathway

1901676:positive regulation of histone H3-K27 acetylation

0072108:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

1903025:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

0033630:positive regulation of cell adhesion mediated by integrin

1900182:positive regulation of protein localization to nucleus

0048286:lung alveolus development

0048666:neuron development

0008285:negative regulation of cell population proliferation

PDB 2Q7N ; 1PVH ; 1EMR
Drugbank NA
KEGG hsa:3976

Related Compounds  (Total: 1)

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C0325
Name: Progesterone


Related Herbs  (Total: 8)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica