HIT-result

Target Description

Type	Detail
Target ID	T21XA6
Protein Name	Leukemia inhibitory factor
Uniprot ID	P15018
Protein Name Alias	LIF; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; Emfilermin
Gene ID	3976
Gene Symbol	LIF
Gene Alias	HILDA
TTD	T29774: Clinical Trial target
Pfam	PF01291
GO	0043410:positive regulation of MAPK cascade 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0072307:regulation of metanephric nephron tubule epithelial cell differentiation 0048863:stem cell differentiation 0005615:extracellular space 0048711:positive regulation of astrocyte differentiation 0007566:embryo implantation 0033138:positive regulation of peptidyl-serine phosphorylation 0001974:blood vessel remodeling 0045835:negative regulation of meiotic nuclear division 0005146:leukemia inhibitory factor receptor binding 0045651:positive regulation of macrophage differentiation 0005102:signaling receptor binding 0007275:multicellular organism development 0005829:cytosol 0070373:negative regulation of ERK1 and ERK2 cascade 0060463:lung lobe morphogenesis 0005576:extracellular region 0008083:growth factor activity 0060707:trophoblast giant cell differentiation 0033141:positive regulation of peptidyl-serine phosphorylation of STAT protein 0060708:spongiotrophoblast differentiation 0046888:negative regulation of hormone secretion 0060426:lung vasculature development 0046697:decidualization 0045595:regulation of cell differentiation 0005125:cytokine activity 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0048644:muscle organ morphogenesis 0045944:positive regulation of transcription by RNA polymerase II 0019827:stem cell population maintenance 0007260:tyrosine phosphorylation of STAT protein 0006955:immune response 0008284:positive regulation of cell population proliferation 0019221:cytokine-mediated signaling pathway 0048861:leukemia inhibitory factor signaling pathway 1901676:positive regulation of histone H3-K27 acetylation 0072108:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 1903025:regulation of RNA polymerase II regulatory region sequence-specific DNA binding 0033630:positive regulation of cell adhesion mediated by integrin 1900182:positive regulation of protein localization to nucleus 0048286:lung alveolus development 0048666:neuron development 0008285:negative regulation of cell population proliferation
PDB	2Q7N ; 1PVH ; 1EMR
Drugbank	NA
KEGG	hsa:3976

Type

Detail

Target ID

T21XA6

Protein Name

Leukemia inhibitory factor

Uniprot ID

P15018

Protein Name Alias

LIF; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; Emfilermin

Gene ID

3976

Gene Symbol

LIF

Gene Alias

HILDA

TTD

T29774: Clinical Trial target

Pfam

PF01291

0043410:positive regulation of MAPK cascade

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0072307:regulation of metanephric nephron tubule epithelial cell differentiation

0048863:stem cell differentiation

0005615:extracellular space

0048711:positive regulation of astrocyte differentiation

0007566:embryo implantation

0033138:positive regulation of peptidyl-serine phosphorylation

0001974:blood vessel remodeling

0045835:negative regulation of meiotic nuclear division

0005146:leukemia inhibitory factor receptor binding

0045651:positive regulation of macrophage differentiation

0005102:signaling receptor binding

0007275:multicellular organism development

0005829:cytosol

0070373:negative regulation of ERK1 and ERK2 cascade

0060463:lung lobe morphogenesis

0005576:extracellular region

0008083:growth factor activity

0060707:trophoblast giant cell differentiation

0033141:positive regulation of peptidyl-serine phosphorylation of STAT protein

0060708:spongiotrophoblast differentiation

0046888:negative regulation of hormone secretion

0060426:lung vasculature development

0046697:decidualization

0045595:regulation of cell differentiation

0005125:cytokine activity

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0048644:muscle organ morphogenesis

0045944:positive regulation of transcription by RNA polymerase II

0019827:stem cell population maintenance

0007260:tyrosine phosphorylation of STAT protein

0006955:immune response

0008284:positive regulation of cell population proliferation

0019221:cytokine-mediated signaling pathway

0048861:leukemia inhibitory factor signaling pathway

1901676:positive regulation of histone H3-K27 acetylation

0072108:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

1903025:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

0033630:positive regulation of cell adhesion mediated by integrin

1900182:positive regulation of protein localization to nucleus

0048286:lung alveolus development

0048666:neuron development

0008285:negative regulation of cell population proliferation

PDB

2Q7N ; 1PVH ; 1EMR

Drugbank

KEGG

hsa:3976

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 8)