HIT-result

Target Description

Type	Detail
Target ID	T11RHZ
Protein Name	Reticulon-4
Uniprot ID	Q9NQC3
Protein Name Alias	Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5
Gene ID	57142
Gene Symbol	RTN4
Gene Alias	KIAA0886; NOGO
TTD	T70062: Clinical Trial target
Pfam	PF02453
GO	0001825:blastocyst formation 0010634:positive regulation of epithelial cell migration 0042981:regulation of apoptotic process 0007413:axonal fasciculation 0034165:positive regulation of toll-like receptor 9 signaling pathway 1905523:positive regulation of macrophage migration 0005789:endoplasmic reticulum membrane 0071456:cellular response to hypoxia 0030334:regulation of cell migration 2000172:regulation of branching morphogenesis of a nerve 0031625:ubiquitin protein ligase binding 0098826:endoplasmic reticulum tubular network membrane 0090156:cellular sphingolipid homeostasis 1990809:endoplasmic reticulum tubular network membrane organization 0006915:apoptotic process 0022009:central nervous system vasculogenesis 0021801:cerebral cortex radial glia guided migration 0071787:endoplasmic reticulum tubular network formation 1902430:negative regulation of amyloid-beta formation 0014069:postsynaptic density 0071782:endoplasmic reticulum tubular network 0030176:integral component of endoplasmic reticulum membrane 0033601:positive regulation of mammary gland epithelial cell proliferation 0035022:positive regulation of Rac protein signal transduction 0071786:endoplasmic reticulum tubular network organization 0005635:nuclear envelope 1905653:positive regulation of artery morphogenesis 0030517:negative regulation of axon extension 0030054:cell junction 0005783:endoplasmic reticulum 0005886:plasma membrane 2001213:negative regulation of vasculogenesis 0035441:cell migration involved in vasculogenesis 0030308:negative regulation of cell growth 0050821:protein stabilization 0051292:nuclear pore complex assembly 0003723:RNA binding 1905580:positive regulation of ERBB3 signaling pathway 0120078:cell adhesion involved in sprouting angiogenesis 0061462:protein localization to lysosome 2000347:positive regulation of hepatocyte proliferation 0045766:positive regulation of angiogenesis 1902624:positive regulation of neutrophil migration 0050771:negative regulation of axonogenesis 0042803:protein homodimerization activity 0060907:positive regulation of macrophage cytokine production 0042995:cell projection 0007029:endoplasmic reticulum organization 0045296:cadherin binding 1905552:positive regulation of protein localization to endoplasmic reticulum 0043025:neuronal cell body 0060317:cardiac epithelial to mesenchymal transition 0051897:positive regulation of protein kinase B signaling 0002523:leukocyte migration involved in inflammatory response
PDB	2JV5 ; 2G31
Drugbank	NA
KEGG	hsa:57142

Type

Detail

Target ID

T11RHZ

Protein Name

Reticulon-4

Uniprot ID

Q9NQC3

Protein Name Alias

Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5

Gene ID

57142

Gene Symbol

RTN4

Gene Alias

KIAA0886; NOGO

TTD

T70062: Clinical Trial target

Pfam

PF02453

0001825:blastocyst formation

0010634:positive regulation of epithelial cell migration

0042981:regulation of apoptotic process

0007413:axonal fasciculation

0034165:positive regulation of toll-like receptor 9 signaling pathway

1905523:positive regulation of macrophage migration

0005789:endoplasmic reticulum membrane

0071456:cellular response to hypoxia

0030334:regulation of cell migration

2000172:regulation of branching morphogenesis of a nerve

0031625:ubiquitin protein ligase binding

0098826:endoplasmic reticulum tubular network membrane

0090156:cellular sphingolipid homeostasis

1990809:endoplasmic reticulum tubular network membrane organization

0006915:apoptotic process

0022009:central nervous system vasculogenesis

0021801:cerebral cortex radial glia guided migration

0071787:endoplasmic reticulum tubular network formation

1902430:negative regulation of amyloid-beta formation

0014069:postsynaptic density

0071782:endoplasmic reticulum tubular network

0030176:integral component of endoplasmic reticulum membrane

0033601:positive regulation of mammary gland epithelial cell proliferation

0035022:positive regulation of Rac protein signal transduction

0071786:endoplasmic reticulum tubular network organization

0005635:nuclear envelope

1905653:positive regulation of artery morphogenesis

0030517:negative regulation of axon extension

0030054:cell junction

0005783:endoplasmic reticulum

0005886:plasma membrane

2001213:negative regulation of vasculogenesis

0035441:cell migration involved in vasculogenesis

0030308:negative regulation of cell growth

0050821:protein stabilization

0051292:nuclear pore complex assembly

0003723:RNA binding

1905580:positive regulation of ERBB3 signaling pathway

0120078:cell adhesion involved in sprouting angiogenesis

0061462:protein localization to lysosome

2000347:positive regulation of hepatocyte proliferation

0045766:positive regulation of angiogenesis

1902624:positive regulation of neutrophil migration

0050771:negative regulation of axonogenesis

0042803:protein homodimerization activity

0060907:positive regulation of macrophage cytokine production

0042995:cell projection

0007029:endoplasmic reticulum organization

0045296:cadherin binding

1905552:positive regulation of protein localization to endoplasmic reticulum

0043025:neuronal cell body

0060317:cardiac epithelial to mesenchymal transition

0051897:positive regulation of protein kinase B signaling

0002523:leukocyte migration involved in inflammatory response

PDB

2JV5 ; 2G31

Drugbank

KEGG

hsa:57142

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 8)