HIT-result

Target Description

Type	Detail
Target ID	T60DN8
Protein Name	Bcl-2-like protein 11
Uniprot ID	O43521
Protein Name Alias	Bcl2-L-11; Bcl2-interacting mediator of cell death
Gene ID	10018
Gene Symbol	BCL2L11
Gene Alias	BIM
TTD	NA
Pfam	PF08945 ; PF06773
GO	1904646:cellular response to amyloid-beta 0060139:positive regulation of apoptotic process by virus 0043029:T cell homeostasis 0070242:thymocyte apoptotic process 0097140:BIM-BCL-xl complex 0048066:developmental pigmentation 0048070:regulation of developmental pigmentation 0043583:ear development 2001244:positive regulation of intrinsic apoptotic signaling pathway 0008630:intrinsic apoptotic signaling pathway in response to DNA damage 0007420:brain development 0012505:endomembrane system 1902263:apoptotic process involved in embryonic digit morphogenesis 2000271:positive regulation of fibroblast apoptotic process 0048536:spleen development 0035148:tube formation 0005829:cytosol 0042981:regulation of apoptotic process 0043065:positive regulation of apoptotic process 0046620:regulation of organ growth 0097192:extrinsic apoptotic signaling pathway in absence of ligand 0097136:Bcl-2 family protein complex 0007283:spermatogenesis 0006915:apoptotic process 0001783:B cell apoptotic process 1903896:positive regulation of IRE1-mediated unfolded protein response 0048563:post-embryonic animal organ morphogenesis 0007160:cell-matrix adhesion 0097141:BIM-BCL-2 complex 0042475:odontogenesis of dentin-containing tooth 0001701:in utero embryonic development 0048538:thymus development 0001822:kidney development 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0007127:meiosis I 0043525:positive regulation of neuron apoptotic process 1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 0071392:cellular response to estradiol stimulus 0005741:mitochondrial outer membrane 0005739:mitochondrion 0019898:extrinsic component of membrane 0001844:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 0071385:cellular response to glucocorticoid stimulus 0031334:positive regulation of protein-containing complex assembly 0019901:protein kinase binding 0034263:positive regulation of autophagy in response to ER overload 0019221:cytokine-mediated signaling pathway 0008584:male gonad development 0045787:positive regulation of cell cycle 0090200:positive regulation of release of cytochrome c from mitochondria 0001782:B cell homeostasis 0008017:microtubule binding 0002262:myeloid cell homeostasis 0030879:mammary gland development 0034976:response to endoplasmic reticulum stress 0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
PDB	4QVF ; 3KJ1 ; 2VM6 ; 4ZIE ; 6QFI ; 5VX3 ; 3KJ0 ; 3IO9 ; 4YJ4 ; 5VX2 ; 5AGW ; 6UA3 ; 2V6Q ; 6X8O ; 5VWZ ; 4ZIH ; 5C3G ; 5WOS ; 6UAB ; 5AGX ; 5VWY ; 4D2M ; 2NL9 ; 2YQ6 ; 4B4S ; 4ZIF ; 2K7W ; 5VWV ; 2WH6 ; 4A1U ; 6TQQ ; 2YQ7 ; 4UF3 ; 3FDL ; 3IO8 ; 3D7V ; 5VWX ; 1F95 ; 4A1W ; 5VWW ; 6RJP ; 3KJ2 ; 5VX0
Drugbank	NA
KEGG	hsa:10018

Type

Detail

Target ID

T60DN8

Protein Name

Bcl-2-like protein 11

Uniprot ID

O43521

Protein Name Alias

Bcl2-L-11; Bcl2-interacting mediator of cell death

Gene ID

10018

Gene Symbol

BCL2L11

Gene Alias

BIM

TTD

Pfam

PF08945 ; PF06773

1904646:cellular response to amyloid-beta

0060139:positive regulation of apoptotic process by virus

0043029:T cell homeostasis

0070242:thymocyte apoptotic process

0097140:BIM-BCL-xl complex

0048066:developmental pigmentation

0048070:regulation of developmental pigmentation

0043583:ear development

2001244:positive regulation of intrinsic apoptotic signaling pathway

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0007420:brain development

0012505:endomembrane system

1902263:apoptotic process involved in embryonic digit morphogenesis

2000271:positive regulation of fibroblast apoptotic process

0048536:spleen development

0035148:tube formation

0005829:cytosol

0042981:regulation of apoptotic process

0043065:positive regulation of apoptotic process

0046620:regulation of organ growth

0097192:extrinsic apoptotic signaling pathway in absence of ligand

0097136:Bcl-2 family protein complex

0007283:spermatogenesis

0006915:apoptotic process

0001783:B cell apoptotic process

1903896:positive regulation of IRE1-mediated unfolded protein response

0048563:post-embryonic animal organ morphogenesis

0007160:cell-matrix adhesion

0097141:BIM-BCL-2 complex

0042475:odontogenesis of dentin-containing tooth

0001701:in utero embryonic development

0048538:thymus development

0001822:kidney development

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0007127:meiosis I

0043525:positive regulation of neuron apoptotic process

1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

0071392:cellular response to estradiol stimulus

0005741:mitochondrial outer membrane

0005739:mitochondrion

0019898:extrinsic component of membrane

0001844:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

0071385:cellular response to glucocorticoid stimulus

0031334:positive regulation of protein-containing complex assembly

0019901:protein kinase binding

0034263:positive regulation of autophagy in response to ER overload

0019221:cytokine-mediated signaling pathway

0008584:male gonad development

0045787:positive regulation of cell cycle

0090200:positive regulation of release of cytochrome c from mitochondria

0001782:B cell homeostasis

0008017:microtubule binding

0002262:myeloid cell homeostasis

0030879:mammary gland development

0034976:response to endoplasmic reticulum stress

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

PDB

4QVF ; 3KJ1 ; 2VM6 ; 4ZIE ; 6QFI ; 5VX3 ; 3KJ0 ; 3IO9 ; 4YJ4 ; 5VX2 ; 5AGW ; 6UA3 ; 2V6Q ; 6X8O ; 5VWZ ; 4ZIH ; 5C3G ; 5WOS ; 6UAB ; 5AGX ; 5VWY ; 4D2M ; 2NL9 ; 2YQ6 ; 4B4S ; 4ZIF ; 2K7W ; 5VWV ; 2WH6 ; 4A1U ; 6TQQ ; 2YQ7 ; 4UF3 ; 3FDL ; 3IO8 ; 3D7V ; 5VWX ; 1F95 ; 4A1W ; 5VWW ; 6RJP ; 3KJ2 ; 5VX0

Drugbank

KEGG

hsa:10018

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1033	Fang Ji	防己	Fourstamen stephania	Stephania tetrandra
H0615	Wu Zhi Mao Tao	五指毛桃	five-finger fig root	Ficus simplicissima
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0341	Qing Feng Teng	青风藤	Orientvine	Sinomenium acutum
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0603	Wu Tong Ye Jin Gao	梧桐叶浸膏	Parasol trees	Firmiana simplex
H1212	Hu Ye Gan Jin Gao	槲叶干浸膏	NA	Quercus dentata
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0087	Ju Gu Ye	枸骨叶	FOLIUM iLICIS cORNUTAE	Ilex cornuta
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 15)