HIT-result

Target Description

Type	Detail
Target ID	T19CTK
Protein Name	Serine/threonine-protein kinase ATR
Uniprot ID	Q13535
Protein Name Alias	EC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1
Gene ID	545
Gene Symbol	ATR
Gene Alias	FRP1
TTD	T97155: Clinical Trial target
Pfam	PF02260 ; PF00454 ; PF08064 ; PF02259
GO	0003677:DNA binding 0005634:nucleus 0005694:chromosome 0071480:cellular response to gamma radiation 0007275:multicellular organism development 0046777:protein autophosphorylation 0090399:replicative senescence 0004672:protein kinase activity 0106310:protein serine kinase activity 0008156:negative regulation of DNA replication 1900034:regulation of cellular response to heat 0004674:protein serine/threonine kinase activity 0106311:protein threonine kinase activity 0070198:protein localization to chromosome, telomeric region 0097694:establishment of RNA localization to telomere 0034644:cellular response to UV 0018105:peptidyl-serine phosphorylation 0016605:PML body 0032405:MutLalpha complex binding 0031297:replication fork processing 1901796:regulation of signal transduction by p53 class mediator 0043517:positive regulation of DNA damage response, signal transduction by p53 class mediator 0005524:ATP binding 0032407:MutSalpha complex binding 0006281:DNA repair 0036297:interstrand cross-link repair 0042493:response to drug 0006260:DNA replication 0005794:Golgi apparatus 0032212:positive regulation of telomere maintenance via telomerase 0005654:nucleoplasm 1904884:positive regulation of telomerase catalytic core complex assembly 0000077:DNA damage checkpoint 0097695:establishment of protein-containing complex localization to telomere 0000723:telomere maintenance 0006974:cellular response to DNA damage stimulus
PDB	5YZ0
Drugbank	NA
KEGG	hsa:545

Type

Detail

Target ID

T19CTK

Protein Name

Serine/threonine-protein kinase ATR

Uniprot ID

Q13535

Protein Name Alias

EC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1

Gene ID

545

Gene Symbol

ATR

Gene Alias

FRP1

TTD

T97155: Clinical Trial target

Pfam

PF02260 ; PF00454 ; PF08064 ; PF02259

0003677:DNA binding

0005634:nucleus

0005694:chromosome

0071480:cellular response to gamma radiation

0007275:multicellular organism development

0046777:protein autophosphorylation

0090399:replicative senescence

0004672:protein kinase activity

0106310:protein serine kinase activity

0008156:negative regulation of DNA replication

1900034:regulation of cellular response to heat

0004674:protein serine/threonine kinase activity

0106311:protein threonine kinase activity

0070198:protein localization to chromosome, telomeric region

0097694:establishment of RNA localization to telomere

0034644:cellular response to UV

0018105:peptidyl-serine phosphorylation

0016605:PML body

0032405:MutLalpha complex binding

0031297:replication fork processing

1901796:regulation of signal transduction by p53 class mediator

0043517:positive regulation of DNA damage response, signal transduction by p53 class mediator

0005524:ATP binding

0032407:MutSalpha complex binding

0006281:DNA repair

0036297:interstrand cross-link repair

0042493:response to drug

0006260:DNA replication

0005794:Golgi apparatus

0032212:positive regulation of telomere maintenance via telomerase

0005654:nucleoplasm

1904884:positive regulation of telomerase catalytic core complex assembly

0000077:DNA damage checkpoint

0097695:establishment of protein-containing complex localization to telomere

0000723:telomere maintenance

0006974:cellular response to DNA damage stimulus

PDB

5YZ0

Drugbank

KEGG

hsa:545

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0615	Wu Zhi Mao Tao	五指毛桃	five-finger fig root	Ficus simplicissima
H0603	Wu Tong Ye Jin Gao	梧桐叶浸膏	Parasol trees	Firmiana simplex
H1033	Fang Ji	防己	Fourstamen stephania	Stephania tetrandra
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H0341	Qing Feng Teng	青风藤	Orientvine	Sinomenium acutum
H1212	Hu Ye Gan Jin Gao	槲叶干浸膏	NA	Quercus dentata
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H0087	Ju Gu Ye	枸骨叶	FOLIUM iLICIS cORNUTAE	Ilex cornuta
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 15)