HIT-result

Target Description

Type	Detail
Target ID	T89A2U
Protein Name	Hsp90 co-chaperone Cdc37
Uniprot ID	Q16543
Protein Name Alias	Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37
Gene ID	11140
Gene Symbol	CDC37
Gene Alias	CDC37A
TTD	T94366: Research target
Pfam	PF08565 ; PF08564 ; PF03234
GO	0070062:extracellular exosome 0060544:regulation of necroptotic process 0098779:positive regulation of mitophagy in response to mitochondrial depolarization 0006457:protein folding 0051087:chaperone binding 0060334:regulation of interferon-gamma-mediated signaling pathway 0031072:heat shock protein binding 0060338:regulation of type I interferon-mediated signaling pathway 0038128:ERBB2 signaling pathway 0005829:cytosol 0101031:chaperone complex 0050821:protein stabilization 0097110:scaffold protein binding 0019887:protein kinase regulator activity 0005737:cytoplasm 0019900:kinase binding 0006605:protein targeting 0000079:regulation of cyclin-dependent protein serine/threonine kinase activity 0019901:protein kinase binding 0051082:unfolded protein binding 0051879:Hsp90 protein binding 1990565:HSP90-CDC37 chaperone complex 0010608:posttranscriptional regulation of gene expression
PDB	5FWP ; 5FWL ; 2N5X ; 2NCA ; 1US7 ; 5HPE ; 5FWM ; 5FWK ; 2K5B ; 2W0G
Drugbank	NA
KEGG	hsa:11140

Type

Detail

Target ID

T89A2U

Protein Name

Hsp90 co-chaperone Cdc37

Uniprot ID

Q16543

Protein Name Alias

Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37

Gene ID

11140

Gene Symbol

CDC37

Gene Alias

CDC37A

TTD

T94366: Research target

Pfam

PF08565 ; PF08564 ; PF03234

0070062:extracellular exosome

0060544:regulation of necroptotic process

0098779:positive regulation of mitophagy in response to mitochondrial depolarization

0006457:protein folding

0051087:chaperone binding

0060334:regulation of interferon-gamma-mediated signaling pathway

0031072:heat shock protein binding

0060338:regulation of type I interferon-mediated signaling pathway

0038128:ERBB2 signaling pathway

0005829:cytosol

0101031:chaperone complex

0050821:protein stabilization

0097110:scaffold protein binding

0019887:protein kinase regulator activity

0005737:cytoplasm

0019900:kinase binding

0006605:protein targeting

0000079:regulation of cyclin-dependent protein serine/threonine kinase activity

0019901:protein kinase binding

0051082:unfolded protein binding

0051879:Hsp90 protein binding

1990565:HSP90-CDC37 chaperone complex

0010608:posttranscriptional regulation of gene expression

PDB

5FWP ; 5FWL ; 2N5X ; 2NCA ; 1US7 ; 5HPE ; 5FWM ; 5FWK ; 2K5B ; 2W0G

Drugbank

KEGG

hsa:11140

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1007	Dou You	豆油	Soybean oil	Glycine max
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0517	Suan Zao Ren	酸枣仁	Spine date seed	Ziziphus jujuba var. spinosa
H0026	Jiang	姜	Soybean paste	Glycine max
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0516	Suan Zao	酸枣	Spine date	Ziziphus jujuba var. spinosa
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0781	Zao Ren	枣仁	seed of spine date	Ziziphus jujuba var. spinosa
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 17)