Target Description
| Type | Detail |
|---|---|
| Target ID | T90XMB |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 5 |
| Uniprot ID |
P45974 |
| Protein Name Alias | EC 3.4.19.12; Deubiquitinating enzyme 5; Isopeptidase T; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5 |
| Gene ID |
8078 |
| Gene Symbol | USP5 |
| Gene Alias | ISOT |
| TTD | T17067: Preclinical target |
| Pfam | PF00627 ; PF00443 ; PF17807 ; PF02148 |
| GO |
0016567:protein ubiquitination
0008270:zinc ion binding 0005634:nucleus 0005764:lysosome 0043130:ubiquitin binding 0004843:thiol-dependent ubiquitin-specific protease activity 0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process 0016579:protein deubiquitination 0071108:protein K48-linked deubiquitination 0006511:ubiquitin-dependent protein catabolic process 0005829:cytosol 0004197:cysteine-type endopeptidase activity |
| PDB | 2DAK ; 3IHP ; 6DXT ; 6DXH ; 2DAG ; 2G43 ; 6NFT ; 6P9G ; 2G45 |
| Drugbank | NA |
| KEGG | hsa:8078 |
Related Herbs (Total: 47)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0277 | Nan Ban Lan Gen | 南板蓝根 | Indigowoad root | Baphicacanthus cusia |
| H1096 | Ge Hua | 葛花 | flower bud of lobed kudzuvine | Pueraria lobata |
| H0246 | Mi Ma Huang | 蜜麻黄 | Ephedra equisetin | Ephedra sinica |
| H0152 | Ling Zhi Jin Gao | 灵芝浸膏 | NA | Ganoderma lucidum |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H1021 | E Da Xia | 莪大夏 | NA | Oxytropis falcata |
| H1152 | Bai Jie Zi | 白芥子 | White mustard seed | Sinapis alba |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0198 | Ma Huang Gao | 麻黄膏 | Chinese ephedra | Ephedra sinica |
| H1247 | Huang Qi | 黄芪 | Membranous milkvetch | Astragalus membranaceus |
| H0197 | Ma Huang | 麻黄 | Chinese ephedra | Ephedra sinica |
| H1248 | Huang Qi Gan Jin Gao | 黄芪干浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0826 | Chu Mu Dan | 臭牡丹 | rose glorybower | Clerodendrum bungei |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0957 | Dang Gui Teng | 当归藤 | NA | Embelia parviflora |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0705 | Yan Hu Lu Ba | 盐胡芦巴 | Fenugreek | Trigonella foenum-graecum |
| H1250 | Huang Qi Ti Qu Ye | 黄芪提取液 | Membranous milkvetch | Astragalus membranaceus |
| H0200 | Ma Huang Gen | 麻黄根 | Chinese ephedra root | Ephedra sinica |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0533 | Teng Ku Shen | 藤苦参 | NA | Sophora flavescens |
| H0153 | Ling Zhi(1) | 灵芝 | Lucid ganoderma | Ganoderma lucidum |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1202 | Hu Huang Lian | 胡黄连 | Picrorhiza | Picrorhiza kurrooa |
| H0201 | Ma Huang Jin Gao | 麻黄浸膏 | Chinese ephedra | Ephedra sinica |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1094 | Ge Gen | 葛根 | Lobed kudzuvine root | Pueraria lobata |
| H1249 | Huang Qi Jin Gao | 黄芪浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H1095 | Ge Gen Gan Jin Gao | 葛根干浸膏 | Lobed kudzuvine root | Pueraria lobata |
| H0084 | Jiu Li Xiang | 九里香 | Common jasminorange | Murraya paniculata |
| H0111 | Ku Shen | 苦参 | Lightyellow sophora | Sophora flavescens |
| H0575 | Tu Ku Shen | 土苦参 | all-grass of hooker winghead | Sophora flavescens |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0377 | San Ling | 三棱 | Common burreed | Sparganium stoloniferum |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1080 | Gan Ge | 干葛 | Lobed kudzuvine root | Pueraria lobata |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0278 | Nan Ban Lan Gen Jin Gao Fen | 南板蓝根浸膏粉 | Indigowoad root | Baphicacanthus cusia |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0214 | Bei He Huan | 北合欢 | Albizia | Albizia julibrissin |