Compound Description
| ID: C0391 | Common name: Scoparone |
| IUPAC: 6,7-dimethoxychromen-2-one | CAS: CAS:120-08-1 |
| Chembl ID: CHEMBL325864 | Pubchem ID: CID:8417 |
| Formula: C11H10O4 | TCM-ID: TCMC2050 |
| Smiles: COC1=C(C=C2C(=C1)C=CC(=O)O2)OC | |
| Alias:
Coumarin, 6,7-dimethoxy-;
6,7-Dimethoxy-2H-1-benzopyran-2-one; 6,7-Dimethoxy-2H-chromen-2-one; 6,7-Dimethoxycoumarin; 6,7-Dimethylesculetin; Aesculetin dimethyl ether; Escoparone; Esculetin 6,7-dimethyl ether; Esculetin dimethyl ether; NRB 03190; O,O-Dimethylesculetin; O-Methylisoscopoletin; O-Methylscopoletin; Scoparon; Scoparone; Scopoletin methyl ether; Scopoletin monomethyl ether |
Structure:
|
Related Targets (Total: 8)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T13KGH | Tyrosinase | TYR |
P14679 |
B | 1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
B | 1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
B | 1 Reference(s) |
| T31MUM | 5,6-dihydroxyindole-2-carboxylic acid oxidase | TYRP1 |
P17643 |
C | 1 Reference(s) |
| T82G5G | L-dopachrome tautomerase | DCT |
P40126 |
C | 1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
C | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
C | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 41)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0207 | Ma Wei Song Shu Gen | 马尾松树根 | NA | Pinus massoniana |
| H1060 | Fo Shou | 佛手 | Fleshfingered citron | Citrus medica var. sarcodactylis |
| H1080 | Gan Ge | 干葛 | Lobed kudzuvine root | Pueraria lobata |
| H1082 | Gan Lan | 橄榄 | Cabbage | Canarium album |
| H0103 | Ai Ye | 艾叶 | Argy wormwood leaf | Artemisia argyi |
| H0963 | Dao Kou Cao | 倒扣草 | NA | Achyranthes aspera |
| H0418 | Shan Yin Chen | 山茵陈 | Capillary wormwood | Artemisia capillaris |
| H0730 | Ye Ma Zhui | 野马追 | NA | Eupatorium lindleyanum |
| H0727 | Ye Gan Cao | 野甘草 | Sweet broomwort | Scoparia dulcis |
| H0746 | Yin Chen Hao Gan Jin Gao | 茵陈蒿干浸膏 | Capillary wormwood | Artemisia capillaris |
| H0536 | Tian Di Ding | 甜地丁 | Manyflower gueldenstaedtid herb | Viola philippica |
| H0083 | Jiu Jie Cha | 九节茶 | Glabrous sarcandra | Sarcandra glabra |
| H0324 | Qian Jin Ba | 千斤拔 | root of philippine flemingia | Radix moghaniae philippinensis |
| H0920 | Da Ban Bian Lian | 大半边莲 | Asian lobelia | Lobelia chinensis |
| H0344 | Qing Guo | 青果 | Olive | Canarium album |
| H0458 | Shi Hu | 石斛 | Dendrobium | Herba dendrobii |
| H0206 | Ma Wei Song Gen | 马尾松根 | NA | Pinus massoniana |
| H0585 | Tu Yin Chen Hao | 土茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H1095 | Ge Gen Gan Jin Gao | 葛根干浸膏 | Lobed kudzuvine root | Pueraria lobata |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H1235 | Huang Hao | 黄蒿 | Virg ate wormwood | Artemisia scoparia |
| H0754 | Ying Bu Bo | 鹰不泊 | Avicenna’s pricklyash | Zanthoxylum avicennae |
| H0613 | Wu Yue Ai | 五月艾 | Artemisia | Artemisia princeps |
| H0612 | Cao Shan Hu Jin Gao | 草珊瑚浸膏 | NA | Sarcandra glabra |
| H1094 | Ge Gen | 葛根 | Lobed kudzuvine root | Pueraria lobata |
| H0113 | Ban Bian Lian | 半边莲 | Chinese lobelia | Lobelia chinensis |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H0154 | Ai Ye You | 艾叶油 | Argy wormwood leaf | Artemisia argyi |
| H0345 | Qing Guo Tan | 青果炭 | white olive | Canarium album |
| H0506 | Song Xiang | 松香 | Colophony | Pinus massoniana |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H1096 | Ge Hua | 葛花 | flower bud of lobed kudzuvine | Pueraria lobata |
| H0877 | Chuan Niu Xi | 川牛膝 | Mediinal cyathula | Cyathula officinalis |
| H0577 | Tu Niu Xi | 土牛膝 | Common achyranthes | Achyranthes aspera |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H0507 | Song Zhi | 松脂 | Rosin | Pinus massoniana |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H0745 | Yin Chen Hao | 茵陈蒿 | Capillary wormwood | Artemisia capillaris |
| H0233 | Mao Liang Mian Zhen | 毛两面针 | NA | Zanthoxylum nitidum |
Ckey description of the interaction between compound and target