Compound Description
| ID: C1258 | Common name: Coumaric Acid |
| IUPAC: (E)-3-(4-hydroxyphenyl)prop-2-enoic acid | CAS: CAS:25429-38-3 |
| Chembl ID: CHEMBL66879 | Pubchem ID: CID:637542 |
| Formula: C9H8O3 | TCM-ID: TCMC948 |
| Smiles: C1=CC(=CC=C1C=CC(=O)O)O | |
| Alias:
Cinnamic acid, ar-hydroxy-;
3-(Hydroxyphenyl)-2-propenoic acid; Coumaric acid; Hydroxycinnamic acid |
Structure:
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Related Targets (Total: 7)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T13KGH | Tyrosinase | TYR |
P14679 |
A | 1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
A | 1 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
A | 1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
A | 1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
B | 1 Reference(s) |
| T82I7J | C-C motif chemokine 16 | CCL16 |
O15467 |
C | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 126)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0609 | Wu Wei Zi Liu Jin Gao | 五味子流浸膏 | Five-flavor berry | Schisandra chinensis |
| H0064 | Jin Yin Hua | 金银花 | Japanese honeysuckle | Lonicera japonica |
| H1127 | Guang Shan Zha | 广山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H0605 | Wu Wei Zi | 五味子 | Chinese magnoliavine | Schisandra chinensis |
| H1150 | Hai Jin Sha Teng Gan Jin Gao | 海金沙藤干浸膏 | NA | Lygodium japonicum |
| H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
| H0626 | Xi Nan Huang Qin | 西南黄芩 | Yunnan skullcap | Scutellaria amoena |
| H1061 | Bai He | 百合 | Lily | Lilium brownii |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
| H0074 | Jing Jie Tan | 荆芥炭 | NA | Schizonepetae herba |
| H0419 | Shan Zha | 山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H1109 | Bai Hua She She Cao | 白花蛇舌草 | Spreading hedyitis | Oldenlandia diffusa |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H0897 | Chuan Lian | 川楝 | Chinaberry | Melia azedarach |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0255 | Mao Zhao Cao | 猫爪草 | Root of catclaw buttercup | Ranunculus ternatus |
| H0065 | Jin Yin Hua Ti Qu Ye | 金银花提取液 | Japanese honeysuckle | Lonicera japonica |
| H1068 | Bai He Liu Jin Gao | 百合流浸膏 | Lily | Lilium brownii |
| H0607 | Wu Wei Zi Jin Chu Wu | 五味子浸出物 | Five-flavor berry | Schisandra chinensis |
| H1055 | Bai Guo Ren | 白果仁 | ginkgo | Ginkgo biloba |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0057 | Jin Sha Teng | 金沙藤 | NA | Lygodium japonicum |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0423 | Shan Zha Ye | 山楂叶 | NA | Crataegi folium |
| H0045 | Jin Fei Cao | 金沸草 | Japanese inula | Inula japonica |
| H0747 | An Xi Xiang | 安息香 | Sumatra snowbel | Styrax benzoin |
| H0172 | Lu Gen | 芦根 | Common reed rhizome | Phragmites communis |
| H0109 | Ku Lian Zi | 苦楝子 | NA | Melia azedarach |
| H0970 | Di Gu Pi | 地骨皮 | root - bark of chinese wolfberry | Cortex lycii radicis |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H0420 | Shan Zha Chou Gao | 山楂稠膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0663 | Xiao Ji | 小蓟 | Setose thistle | Cirsium setosum |
| H1147 | Hai Jin Sha | 海金砂 | Japanese climbing fern | Lygodium japonicum |
| H1188 | Hong Hua | 红花 | Safflower | Carthamus tinctorius |
| H0075 | Jing Mi | 粳米 | Rice | Oryza sativa |
| H1149 | Hai Jin Sha Teng | 海金沙藤 | NA | Lygodium japonicum |
| H0226 | Man Yue Mei | 蔓越莓 | Cranberry | Vaccinium oxycoccos |
| H0331 | Qiang Huo | 羌活 | Incised notopterygium | Notopterygium incisum |
| H0566 | Cao Cong Rong | 草苁蓉 | Russian boschniakia | Boschniakia rossica |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H1221 | Hua Xiang Shu Guo Xu | 化香树果序 | NA | Platycarya strobilacea |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0750 | Yin Xing Ye | 银杏叶 | Folium ginkgo | Ginkgo biloba |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0688 | Xuan Shen | 玄参 | Ningpo figwort | Scrophularia ningpoensis |
| H0485 | Shui Hong Hua | 水红花 | Fructus polygoni orientalis | Polygonum orientale |
| H0985 | Dian Zhu Ye | 滇竹叶 | Bamboo leaves | Phyllostachys nigra |
| H0427 | Shan Zhu Yu | 山茱萸 | Asiatic cornelian cherry | Cornus officinalis |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0196 | Ma Dou Ling | 马兜铃 | Slender dutchmanspipe | Aristolochia debilis |
| H0422 | Shan Zha Tan | 山楂炭 | Chinese hawthorn | Crataegus pinnatifida |
| H0486 | Shui Hong Hua Ye | 水红花叶 | Fructus polygoni orientalis | Polygonum orientale |
| H1205 | Hu Lu Cha | 葫芦茶 | Triquetrous tadehagi | Tadehagi triquetrum |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |
| H0765 | Chi Dou | 赤豆 | Assuki bean | Vigna angularis |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0354 | Ren Dong Teng | 忍冬藤 | Japanese honeysuckle vine | Lonicera japonica |
| H0900 | Chun Gen Pi | 椿根皮 | Ailanthus bark, tree of heaven bark | Ailanthus altissima |
| H0248 | Mi Ying Su Ke | 蜜罂粟壳 | Opium poppy | Papaver somniferum |
| H0085 | Jiu Yu Rou | 酒萸肉 | Asiatic cornelian cherry | Cornus officinalis |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H1183 | Hong Dou | 红豆 | Hosie ormosia | Ormosia hosiei |
| H1051 | Bai Guo | 白果 | Ginkgo nut | Ginkgo biloba |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H0108 | Ku Lian Pi | 苦楝皮 | Chinaberry-tree bark | Melia azedarach |
| H0757 | Ying Su Ke | 罂粟壳 | Opium poppy pericarp | Papaver somniferum |
| H0632 | Xia Ku Cao | 夏枯草 | Common selfheal | Prunella vulgaris |
| H0768 | Yuan Shen | 元参 | Figwort root | Scrophularia ningpoensis |
| H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
| H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
| H0526 | Tang Gu Te Wu Tou | 唐古特乌头 | NA | Aconitum tanguticum |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H0421 | Shan Zha Qing Gao | 山楂清膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0697 | Ya Ma Zi | 亚麻子 | Common flax seed | Linum usitatissimum |
| H1116 | Guan Mu Tong | 关木通 | Manchurian dutchmanspipe | Aristolochia manshuriensis |
| H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
| H0166 | Long Kui | 龙葵 | Black nightshade | Solanum nigrum |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0214 | Bei He Huan | 北合欢 | Albizia | Albizia julibrissin |
| H0510 | Su He Xiang | 苏合香 | Oriental sweetgum resin | Liquidambar orientalis |
| H0606 | Wu Wei Zi Chun Jin Gao | 五味子醇浸膏 | Five-flavor berry | Schisandra chinensis |
| H0006 | Bai Qu Cai | 白屈菜 | Greater celandine | Chelidonium majus |
| H0733 | Ye Shan Zha | 野山楂 | nippon bawthorn | Crataegus pinnatifida |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0772 | Yue Ji Hua | 月季花 | Chinese rose | Rosa chinensis |
| H0700 | Ya Zhi Cao | 鸭跖草 | Common dayflower | Commelina communis |
| H1022 | E Zhu | 莪术 | Zedoray rhizome | Curcuma aeruginosa |
| H0938 | Da Suan | 大蒜 | Garlic | Allium sativum |
| H0837 | Zhu Ye | 竹叶 | Bamboo leaves | Phyllostachys nigra |
| H0608 | Wu Wei Zi Jin Gao | 五味子浸膏 | Five-flavor berry | Schisandra chinensis |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0642 | Xiang Jia Pi | 香加皮 | Chinese silkvine root-bark | Periploca sepium |
| H1129 | Guang Xi E Zhu | 广西莪术 | rhizome of kwangsi turmeric | Rhizoma curcumae |
| H0346 | Qing Mu Xiang | 青木香 | Slender dutchmanspipe root | Aristolochia debilis |
| H0307 | Peng E Zhu | 蓬莪术 | Zedoray rhizome | Rhizoma curcumae |
| H0881 | Chuan Qiang Huo | 川羌活 | Incised notopterygium | Notopterygium incisum |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0073 | Jing Jie Sui | 荆芥穗 | NA | Schizonepetae spica |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0686 | Xuan Fu Hua | 旋覆花 | Inula flower | Flos inulae |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H0377 | San Ling | 三棱 | Common burreed | Sparganium stoloniferum |
| H1220 | Hua Xiang Shu Guo | 化香树果 | NA | Platycarya strobilacea |
| H0056 | Jin Qiao Mai | 金荞麦 | Wild buckwheat rhizome | Rhizoma fagopyri cymosi |
| H1148 | Hai Jin Sha Cao | 海金沙草 | NA | Lygodium japonicum |
| H0756 | Ying Su | 罂粟 | Opium poppy | Papaver somniferum |
Ckey description of the interaction between compound and target