HIT-result

Target Description

Type	Detail
Target ID	T41B8C
Protein Name	Peroxiredoxin-5, mitochondrial
Uniprot ID	P30044
Protein Name Alias	EC 1.11.1.24; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin-dependent peroxiredoxin 5
Gene ID	25824
Gene Symbol	PRDX5
Gene Alias	ACR1
TTD	T77009: Successful target
Pfam	PF08534
GO	0070062:extracellular exosome 0005615:extracellular space 0051354:negative regulation of oxidoreductase activity 0043066:negative regulation of apoptotic process 0001016:RNA polymerase III transcription regulatory region sequence-specific DNA binding 0005102:signaling receptor binding 0045454:cell redox homeostasis 0005829:cytosol 0072541:peroxynitrite reductase activity 0070995:NADPH oxidation 2001057:reactive nitrogen species metabolic process 0005737:cytoplasm 0008379:thioredoxin peroxidase activity 0043027:cysteine-type endopeptidase inhibitor activity involved in apoptotic process 0048471:perinuclear region of cytoplasm 0005777:peroxisome 0051920:peroxiredoxin activity 0005739:mitochondrion 0034599:cellular response to oxidative stress 0005782:peroxisomal matrix 0016209:antioxidant activity 0004601:peroxidase activity 0005634:nucleus 0032967:positive regulation of collagen biosynthetic process 0005759:mitochondrial matrix 0006954:inflammatory response 0006979:response to oxidative stress 0042744:hydrogen peroxide catabolic process 0060785:regulation of apoptosis involved in tissue homeostasis 0043231:intracellular membrane-bounded organelle 0016480:negative regulation of transcription by RNA polymerase III 0034614:cellular response to reactive oxygen species 0031410:cytoplasmic vesicle
PDB	2VL3 ; 1H4O ; 4K7I ; 4K7O ; 3MNG ; 2VL2 ; 4MMM ; 2VL9 ; 1OC3 ; 1URM ; 4K7N ; 1HD2
Drugbank	DB00995 ; DB09221 ; DB03608
KEGG	hsa:25824

Type

Detail

Target ID

T41B8C

Protein Name

Peroxiredoxin-5, mitochondrial

Uniprot ID

P30044

Protein Name Alias

EC 1.11.1.24; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin-dependent peroxiredoxin 5

Gene ID

25824

Gene Symbol

PRDX5

Gene Alias

ACR1

TTD

T77009: Successful target

Pfam

PF08534

0070062:extracellular exosome

0005615:extracellular space

0051354:negative regulation of oxidoreductase activity

0043066:negative regulation of apoptotic process

0001016:RNA polymerase III transcription regulatory region sequence-specific DNA binding

0005102:signaling receptor binding

0045454:cell redox homeostasis

0005829:cytosol

0072541:peroxynitrite reductase activity

0070995:NADPH oxidation

2001057:reactive nitrogen species metabolic process

0005737:cytoplasm

0008379:thioredoxin peroxidase activity

0043027:cysteine-type endopeptidase inhibitor activity involved in apoptotic process

0048471:perinuclear region of cytoplasm

0005777:peroxisome

0051920:peroxiredoxin activity

0005739:mitochondrion

0034599:cellular response to oxidative stress

0005782:peroxisomal matrix

0016209:antioxidant activity

0004601:peroxidase activity

0005634:nucleus

0032967:positive regulation of collagen biosynthetic process

0005759:mitochondrial matrix

0006954:inflammatory response

0006979:response to oxidative stress

0042744:hydrogen peroxide catabolic process

0060785:regulation of apoptosis involved in tissue homeostasis

0043231:intracellular membrane-bounded organelle

0016480:negative regulation of transcription by RNA polymerase III

0034614:cellular response to reactive oxygen species

0031410:cytoplasmic vesicle

PDB

2VL3 ; 1H4O ; 4K7I ; 4K7O ; 3MNG ; 2VL2 ; 4MMM ; 2VL9 ; 1OC3 ; 1URM ; 4K7N ; 1HD2

Drugbank

DB00995 ; DB09221 ; DB03608

KEGG

hsa:25824

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0421	Shan Zha Qing Gao	山楂清膏	Chinese hawthorn	Crataegus pinnatifida
H0663	Xiao Ji	小蓟	Setose thistle	Cirsium setosum
H0420	Shan Zha Chou Gao	山楂稠膏	Chinese hawthorn	Crataegus pinnatifida
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0158	Liu Ling Ju	六棱菊	NA	Laggera alata
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H1229	Bai Mu Xiang	白木香	Chinese eaglewood	Aquilaria sinensis
H0772	Yue Ji Hua	月季花	Chinese rose	Rosa chinensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0419	Shan Zha	山楂	Chinese hawthorn	Crataegus pinnatifida
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H0527	Tao	桃	Peach	Prunus persica
H0733	Ye Shan Zha	野山楂	nippon bawthorn	Crataegus pinnatifida
H0422	Shan Zha Tan	山楂炭	Chinese hawthorn	Crataegus pinnatifida
H1127	Guang Shan Zha	广山楂	Chinese hawthorn	Crataegus pinnatifida

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 30)