HIT-result

Target Description

Type	Detail
Target ID	T55WN8
Protein Name	Proteinase-activated receptor 2
Uniprot ID	P55085
Protein Name Alias	PAR-2; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1
Gene ID	2150
Gene Symbol	F2RL1
Gene Alias	GPR11; PAR2
TTD	T62841: Patented target
Pfam	PF00001
GO	0015057:thrombin-activated receptor activity 0097029:mature conventional dendritic cell differentiation 0032731:positive regulation of interleukin-1 beta production 0030836:positive regulation of actin filament depolymerization 0031681:G-protein beta-subunit binding 0001965:G-protein alpha-subunit binding 0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0032755:positive regulation of interleukin-6 production 0051607:defense response to virus 0038023:signaling receptor activity 0032722:positive regulation of chemokine production 0030193:regulation of blood coagulation 0050900:leukocyte migration 0050927:positive regulation of positive chemotaxis 0043122:regulation of I-kappaB kinase/NF-kappaB signaling 0007186:G protein-coupled receptor signaling pathway 0032757:positive regulation of interleukin-8 production 0031274:positive regulation of pseudopodium assembly 0070963:positive regulation of neutrophil mediated killing of gram-negative bacterium 0034137:positive regulation of toll-like receptor 2 signaling pathway 0043547:positive regulation of GTPase activity 0005102:signaling receptor binding 0007596:blood coagulation 0002286:T cell activation involved in immune response 0043311:positive regulation of eosinophil degranulation 0042311:vasodilation 0034140:negative regulation of toll-like receptor 3 signaling pathway 0032733:positive regulation of interleukin-10 production 0034141:positive regulation of toll-like receptor 3 signaling pathway 0046329:negative regulation of JNK cascade 0032729:positive regulation of interferon-gamma production 0003104:positive regulation of glomerular filtration 1900135:positive regulation of renin secretion into blood stream 0005794:Golgi apparatus 0005886:plasma membrane 0061028:establishment of endothelial barrier 0004930:G protein-coupled receptor activity 0005769:early endosome 0070661:leukocyte proliferation 0050921:positive regulation of chemotaxis 0045087:innate immune response 0035025:positive regulation of Rho protein signal transduction 0005887:integral component of plasma membrane 0045217:cell-cell junction maintenance 0032682:negative regulation of chemokine production 0046330:positive regulation of JNK cascade 0031143:pseudopodium 0046328:regulation of JNK cascade 0030335:positive regulation of cell migration 0060100:positive regulation of phagocytosis, engulfment 0045944:positive regulation of transcription by RNA polymerase II 2000341:regulation of chemokine (C-X-C motif) ligand 2 production 0002690:positive regulation of leukocyte chemotaxis 0032930:positive regulation of superoxide anion generation 0070374:positive regulation of ERK1 and ERK2 cascade 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0006954:inflammatory response 0042119:neutrophil activation 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0002720:positive regulation of cytokine production involved in immune response 0034145:positive regulation of toll-like receptor 4 signaling pathway 0010804:negative regulation of tumor necrosis factor-mediated signaling pathway 0007204:positive regulation of cytosolic calcium ion concentration
PDB	5NJ6 ; 5NDZ ; 5NDD
Drugbank	NA
KEGG	hsa:2150

Type

Detail

Target ID

T55WN8

Protein Name

Proteinase-activated receptor 2

Uniprot ID

P55085

Protein Name Alias

PAR-2; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1

Gene ID

2150

Gene Symbol

F2RL1

Gene Alias

GPR11; PAR2

TTD

T62841: Patented target

Pfam

PF00001

0015057:thrombin-activated receptor activity

0097029:mature conventional dendritic cell differentiation

0032731:positive regulation of interleukin-1 beta production

0030836:positive regulation of actin filament depolymerization

0031681:G-protein beta-subunit binding

0001965:G-protein alpha-subunit binding

0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

0032755:positive regulation of interleukin-6 production

0051607:defense response to virus

0038023:signaling receptor activity

0032722:positive regulation of chemokine production

0030193:regulation of blood coagulation

0050900:leukocyte migration

0050927:positive regulation of positive chemotaxis

0043122:regulation of I-kappaB kinase/NF-kappaB signaling

0007186:G protein-coupled receptor signaling pathway

0032757:positive regulation of interleukin-8 production

0031274:positive regulation of pseudopodium assembly

0070963:positive regulation of neutrophil mediated killing of gram-negative bacterium

0034137:positive regulation of toll-like receptor 2 signaling pathway

0043547:positive regulation of GTPase activity

0005102:signaling receptor binding

0007596:blood coagulation

0002286:T cell activation involved in immune response

0043311:positive regulation of eosinophil degranulation

0042311:vasodilation

0034140:negative regulation of toll-like receptor 3 signaling pathway

0032733:positive regulation of interleukin-10 production

0034141:positive regulation of toll-like receptor 3 signaling pathway

0046329:negative regulation of JNK cascade

0032729:positive regulation of interferon-gamma production

0003104:positive regulation of glomerular filtration

1900135:positive regulation of renin secretion into blood stream

0005794:Golgi apparatus

0005886:plasma membrane

0061028:establishment of endothelial barrier

0004930:G protein-coupled receptor activity

0005769:early endosome

0070661:leukocyte proliferation

0050921:positive regulation of chemotaxis

0045087:innate immune response

0035025:positive regulation of Rho protein signal transduction

0005887:integral component of plasma membrane

0045217:cell-cell junction maintenance

0032682:negative regulation of chemokine production

0046330:positive regulation of JNK cascade

0031143:pseudopodium

0046328:regulation of JNK cascade

0030335:positive regulation of cell migration

0060100:positive regulation of phagocytosis, engulfment

0045944:positive regulation of transcription by RNA polymerase II

2000341:regulation of chemokine (C-X-C motif) ligand 2 production

0002690:positive regulation of leukocyte chemotaxis

0032930:positive regulation of superoxide anion generation

0070374:positive regulation of ERK1 and ERK2 cascade

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0006954:inflammatory response

0042119:neutrophil activation

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0002720:positive regulation of cytokine production involved in immune response

0034145:positive regulation of toll-like receptor 4 signaling pathway

0010804:negative regulation of tumor necrosis factor-mediated signaling pathway

0007204:positive regulation of cytosolic calcium ion concentration

PDB

5NJ6 ; 5NDZ ; 5NDD

Drugbank

KEGG

hsa:2150

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Name: Metformin

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Name: Nordihydroguaiaretic Acid

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Name: Nordihydroguaiaretic Acid

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Name: Adenosine Triphosphate

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Name: heparin

< 1 2 >

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0242	Bei Sha Shen Liu Jin Gao	北沙参流浸膏	Glehnia littoralis	Glehnia littoralis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0239	Bei Sha Shen	北沙参	Coastal glehnia	Glehnia littoralis
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0123	La Jiao Liu Jin Gao	辣椒流浸膏	Bush redpepper	Capsicum frutescens
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0854	Zi Wei Gen Pi	紫葳根皮	NA	Campsis grandiflora
H0121	La Jiao Jin Chu Ye	辣椒浸出液	Bush redpepper	Capsicum frutescens
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0119	La Jiao	辣椒	Bush redpepper	Capsicum frutescens
H0122	La Jiao Jin Gao	辣椒浸膏	Bush redpepper	Capsicum frutescens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 6)

Related Herbs (Total: 16)