Target Description

Type Detail
Target ID T55WN8
Protein Name Proteinase-activated receptor 2
Uniprot ID P55085
Protein Name Alias PAR-2;  Coagulation factor II receptor-like 1;  G-protein coupled receptor 11;  Thrombin receptor-like 1
Gene ID 2150
Gene Symbol F2RL1
Gene Alias GPR11;  PAR2
TTD T62841: Patented target
Pfam PF00001
GO
0015057:thrombin-activated receptor activity

0097029:mature conventional dendritic cell differentiation

0032731:positive regulation of interleukin-1 beta production

0030836:positive regulation of actin filament depolymerization

0031681:G-protein beta-subunit binding

0001965:G-protein alpha-subunit binding

0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

0032755:positive regulation of interleukin-6 production

0051607:defense response to virus

0038023:signaling receptor activity

0032722:positive regulation of chemokine production

0030193:regulation of blood coagulation

0050900:leukocyte migration

0050927:positive regulation of positive chemotaxis

0043122:regulation of I-kappaB kinase/NF-kappaB signaling

0007186:G protein-coupled receptor signaling pathway

0032757:positive regulation of interleukin-8 production

0031274:positive regulation of pseudopodium assembly

0070963:positive regulation of neutrophil mediated killing of gram-negative bacterium

0034137:positive regulation of toll-like receptor 2 signaling pathway

0043547:positive regulation of GTPase activity

0005102:signaling receptor binding

0007596:blood coagulation

0002286:T cell activation involved in immune response

0043311:positive regulation of eosinophil degranulation

0042311:vasodilation

0034140:negative regulation of toll-like receptor 3 signaling pathway

0032733:positive regulation of interleukin-10 production

0034141:positive regulation of toll-like receptor 3 signaling pathway

0046329:negative regulation of JNK cascade

0032729:positive regulation of interferon-gamma production

0003104:positive regulation of glomerular filtration

1900135:positive regulation of renin secretion into blood stream

0005794:Golgi apparatus

0005886:plasma membrane

0061028:establishment of endothelial barrier

0004930:G protein-coupled receptor activity

0005769:early endosome

0070661:leukocyte proliferation

0050921:positive regulation of chemotaxis

0045087:innate immune response

0035025:positive regulation of Rho protein signal transduction

0005887:integral component of plasma membrane

0045217:cell-cell junction maintenance

0032682:negative regulation of chemokine production

0046330:positive regulation of JNK cascade

0031143:pseudopodium

0046328:regulation of JNK cascade

0030335:positive regulation of cell migration

0060100:positive regulation of phagocytosis, engulfment

0045944:positive regulation of transcription by RNA polymerase II

2000341:regulation of chemokine (C-X-C motif) ligand 2 production

0002690:positive regulation of leukocyte chemotaxis

0032930:positive regulation of superoxide anion generation

0070374:positive regulation of ERK1 and ERK2 cascade

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0006954:inflammatory response

0042119:neutrophil activation

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0002720:positive regulation of cytokine production involved in immune response

0034145:positive regulation of toll-like receptor 4 signaling pathway

0010804:negative regulation of tumor necrosis factor-mediated signaling pathway

0007204:positive regulation of cytosolic calcium ion concentration

PDB 5NJ6 ; 5NDZ ; 5NDD
Drugbank NA
KEGG hsa:2150

Related Compounds  (Total: 6)

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C0213
Name: Metformin
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C0254
Name: Nordihydroguaiaretic Acid
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C0615
Name: Nordihydroguaiaretic Acid
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C0852
Name: Adenosine Triphosphate
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C1113
Name: heparin


Related Herbs  (Total: 16)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0854 Zi Wei Gen Pi紫葳根皮 NACampsis grandiflora
H0123 La Jiao Liu Jin Gao辣椒流浸膏 Bush redpepperCapsicum frutescens
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0119 La Jiao辣椒 Bush redpepperCapsicum frutescens
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0121 La Jiao Jin Chu Ye辣椒浸出液 Bush redpepperCapsicum frutescens
H0122 La Jiao Jin Gao辣椒浸膏 Bush redpepperCapsicum frutescens
H0357 Ren Shen人参 GinsengPanax ginseng
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis