HIT-result

Type	Detail
Target ID	T95GWW
Protein Name	cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Uniprot ID	P27815
Protein Name Alias	EC 3.1.4.53; DPDE2; PDE46
Gene ID	5141
Gene Symbol	PDE4A
Gene Alias	DPDE2
TTD	T61744: Successful target
Pfam	PF18100 ; PF00233
GO	0005886:plasma membrane 0005634:nucleus 0007186:G protein-coupled receptor signaling pathway 0005829:cytosol 0007608:sensory perception of smell 0046872:metal ion binding 0035690:cellular response to drug 0005654:nucleoplasm 0006198:cAMP catabolic process 0004114:3',5'-cyclic-nucleotide phosphodiesterase activity 0010738:regulation of protein kinase A signaling 0032587:ruffle membrane 0007165:signal transduction 0016020:membrane 0043949:regulation of cAMP-mediated signaling 0004115:3',5'-cyclic-AMP phosphodiesterase activity 0048471:perinuclear region of cytoplasm 0030552:cAMP binding
PDB	3TVX ; 2QYK ; 3I8V
Drugbank	DB00975 ; DB05266 ; DB01656 ; DB06479 ; DB06842 ; DB01427 ; DB01088 ; DB00824 ; DB01791 ; DB09283 ; DB08299 ; DB00201 ; DB00277 ; DB01303 ; DB00651 ; DB05219 ; DB08811 ; DB06751
KEGG	hsa:5141

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0022	Jia Ju	假蒟	Sarmentose pepper	Piper sarmentosum
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0024	Jia 蒟ye	假蒟叶	Sarmentose pepper	Piper sarmentosum

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 31)