Target Description

Type Detail
Target ID T65JUB
Protein Name Nucleotide-binding oligomerization domain-containing protein 2
Uniprot ID Q9HC29
Protein Name Alias Caspase recruitment domain-containing protein 15;  Inflammatory bowel disease protein 1
Gene ID 64127
Gene Symbol NOD2
Gene Alias CARD15;  IBD1
TTD T75643: Clinical Trial target
Pfam PF17776 ; PF00619 ; PF05729 ; PF13516 ; PF17779
GO
0003779:actin binding

0032701:negative regulation of interleukin-18 production

0035556:intracellular signal transduction

1901224:positive regulation of NIK/NF-kappaB signaling

0032755:positive regulation of interleukin-6 production

0050871:positive regulation of B cell activation

0071639:positive regulation of monocyte chemotactic protein-1 production

0071407:cellular response to organic cyclic compound

0019901:protein kinase binding

0051879:Hsp90 protein binding

0002227:innate immune response in mucosa

0019899:enzyme binding

0002720:positive regulation of cytokine production involved in immune response

0070374:positive regulation of ERK1 and ERK2 cascade

1904417:positive regulation of xenophagy

0002253:activation of immune response

0060585:positive regulation of prostaglandin-endoperoxide synthase activity

0045944:positive regulation of transcription by RNA polymerase II

0045087:innate immune response

0009595:detection of biotic stimulus

0090022:regulation of neutrophil chemotaxis

0051770:positive regulation of nitric-oxide synthase biosynthetic process

0045335:phagocytic vesicle

0005829:cytosol

0032689:negative regulation of interferon-gamma production

0071222:cellular response to lipopolysaccharide

0016045:detection of bacterium

0032735:positive regulation of interleukin-12 production

0005737:cytoplasm

0006952:defense response

0046330:positive regulation of JNK cascade

0034136:negative regulation of toll-like receptor 2 signaling pathway

0005524:ATP binding

0006965:positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0030277:maintenance of gastrointestinal epithelium

0050700:CARD domain binding

0007254:JNK cascade

0007584:response to nutrient

0032088:negative regulation of NF-kappaB transcription factor activity

0070423:nucleotide-binding oligomerization domain containing signaling pathway

0002221:pattern recognition receptor signaling pathway

0032757:positive regulation of interleukin-8 production

0032760:positive regulation of tumor necrosis factor production

0002710:negative regulation of T cell mediated immunity

0043406:positive regulation of MAP kinase activity

0005739:mitochondrion

0050830:defense response to Gram-positive bacterium

0032720:negative regulation of tumor necrosis factor production

0030544:Hsp70 protein binding

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0002925:positive regulation of humoral immune response mediated by circulating immunoglobulin

0050766:positive regulation of phagocytosis

0042834:peptidoglycan binding

0009986:cell surface

0032695:negative regulation of interleukin-12 production

0050679:positive regulation of epithelial cell proliferation

0071224:cellular response to peptidoglycan

0032500:muramyl dipeptide binding

0044877:protein-containing complex binding

2000363:positive regulation of prostaglandin-E synthase activity

0002862:negative regulation of inflammatory response to antigenic stimulus

0002830:positive regulation of type 2 immune response

0005856:cytoskeleton

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0032731:positive regulation of interleukin-1 beta production

0032498:detection of muramyl dipeptide

0050727:regulation of inflammatory response

0042742:defense response to bacterium

0002606:positive regulation of dendritic cell antigen processing and presentation

2000110:negative regulation of macrophage apoptotic process

0002732:positive regulation of dendritic cell cytokine production

0045747:positive regulation of Notch signaling pathway

0032733:positive regulation of interleukin-10 production

0070498:interleukin-1-mediated signaling pathway

0032874:positive regulation of stress-activated MAPK cascade

0046645:positive regulation of gamma-delta T cell activation

1902523:positive regulation of protein K63-linked ubiquitination

0000187:activation of MAPK activity

0051092:positive regulation of NF-kappaB transcription factor activity

0070431:nucleotide-binding oligomerization domain containing 2 signaling pathway

0046658:anchored component of plasma membrane

0005886:plasma membrane

0071225:cellular response to muramyl dipeptide

0051353:positive regulation of oxidoreductase activity

0032740:positive regulation of interleukin-17 production

0032495:response to muramyl dipeptide

0031982:vesicle

0032991:protein-containing complex

0045089:positive regulation of innate immune response

0005794:Golgi apparatus

0032703:negative regulation of interleukin-2 production

1900017:positive regulation of cytokine production involved in inflammatory response

0016323:basolateral plasma membrane

0043330:response to exogenous dsRNA

0038187:pattern recognition receptor activity

PDB NA
Drugbank DB13615
KEGG hsa:64127

Related Compounds  (Total: 2)

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C0721
Name: Baicalin
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C1125
Name: Baicalin


Related Herbs  (Total: 33)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1227 Huai Zhi槐枝 NASophora japonica
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0527 Tao PeachPrunus persica
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H1225 Huai Mi槐米 NASophora japonica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis