Compound Description
| ID: C1125 | Common name: Baicalin |
| IUPAC: (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | CAS: CAS:21967-41-9 |
| Chembl ID: CHEMBL485818 | Pubchem ID: CID:64982 |
| Formula: C21H18O11 | TCM-ID: TCMC756 |
| Smiles: OC(=O)[C@H]1O[C@@H](Oc2cc3oc(cc(=O)c3c(c2O)O)c2ccccc2)[C@@H]([C@H]([C@@H]1O)O)O | |
| Alias:
Baicalin;
5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid; Baicalein 7-O-glucuronide; Baicalein 7-O-β-D-glucuronide; Baicalein 7-glucuronide |
Structure:
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Related Targets (Total: 37)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T33OPP | Interleukin-6 | IL6 |
P05231 |
A | 1 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
A | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
A | 1 Reference(s) |
| T04WT7 | Fibronectin | FN1 |
P02751 |
A | 1 Reference(s) |
| T65S3S | Tyrosine-protein kinase JAK2 | JAK2 |
O60674 |
A | 1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
A | 1 Reference(s) |
| T43QZ3 | Sclerostin | SOST |
Q9BQB4 |
A | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
A | 3 Reference(s) |
| T60A9R | NA | CYP3A |
NA |
A | 2 Reference(s) |
| T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
A | 1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
A | 1 Reference(s) |
| T65JUB | Nucleotide-binding oligomerization domain-containing protein 2 | NOD2 |
Q9HC29 |
A | 2 Reference(s) |
| T61J7T | Mothers against decapentaplegic homolog 2 | SMAD2 |
Q15796 |
A | 1 Reference(s) |
| T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
A | 1 Reference(s) |
| T09DI4 | Lysine-specific histone demethylase 1A | KDM1A |
O60341 |
A | 1 Reference(s) |
| T73PLT | Sialidase-1 | NEU1 |
Q99519 |
A | 1 Reference(s) |
| T32REB | Calcium/calmodulin-dependent protein kinase type II subunit gamma | CAMK2G |
Q13555 |
A | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
A | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
A | 2 Reference(s) |
| T33JS5 | CCN family member 2 | CCN2 |
P29279 |
A | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
A | 1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
A | 1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
A | 1 Reference(s) |
| T29B10 | Interleukin-17A | IL17A |
Q16552 |
B | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
B | 1 Reference(s) |
| T19XSL | Fatty acid-binding protein, liver | FABP1 |
P07148 |
C | 1 Reference(s) |
| T12PV0 | NA | MEG3 |
NA |
C | 1 Reference(s) |
| T93YV8 | Tumor necrosis factor receptor superfamily member 11B | TNFRSF11B |
O00300 |
C | 1 Reference(s) |
| T47G3X | Glucocorticoid receptor | NR3C1 |
P04150 |
C | 1 Reference(s) |
| T08Q1T | Amiloride-sensitive sodium channel subunit alpha | SCNN1A |
P37088 |
C | 1 Reference(s) |
| T77M4W | Adenosine receptor A2a | ADORA2A |
P29274 |
C | 1 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
C | 1 Reference(s) |
| T99ARN | Forkhead box protein P3 | FOXP3 |
Q9BZS1 |
C | 1 Reference(s) |
| T32JN2 | Beta-glucuronidase | GUSB |
P08236 |
C | 1 Reference(s) |
| T39XYV | Dickkopf-related protein 1 | DKK1 |
O94907 |
C | 1 Reference(s) |
| T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 32)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0530 | Tao Ren Shuang | 桃仁霜 | Peach kernel | Prunus persica |
| H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
| H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
| H0965 | Deng Zhan Xi Xin | 灯盏细辛 | Shortscape fleabane | Erigeron breviscapus |
| H0714 | Yan Tai Chai Hu | 烟台柴胡 | Chinese thorowax | Bupleurum chinense |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H1254 | Huang Qin Tan | 黄芩炭 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0092 | Ju Hua | 菊花 | Florists chrysanthemum flower | Chrysanthemum morifolium |
| H0659 | Chai Hu Jin Gao | 柴胡浸膏 | Chinese thorowax | Bupleurum chinense |
| H0650 | Chai Hu | 柴胡 | Chinese thorowax | Bupleurum chinense |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0529 | Tao Ren | 桃仁 | Peach kernel | Prunus persica |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0429 | Shao Yao | 芍药 | Red peony root | Paeonia obovata |
| H0784 | Chi Shao | 赤芍 | Red peony root | Paeonia obovata |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
| H0531 | Tao Zhi | 桃枝 | Peach juvenile branch | Prunus persica |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
| H1253 | Huang Qin Jin Gao Fen | 黄芩浸膏粉 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0310 | Pian Qin | 片芩 | Scutellaria amoena | Scutellaria baicalensis |
| H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0665 | Chai Hu Shao | 柴胡梢 | Chinese thorowax | Bupleurum chinense |
| H0527 | Tao | 桃 | Peach | Prunus persica |
| H1161 | Hang Ju | 杭菊 | Chrysanthemum flower | Chrysanthemum morifolium |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H1252 | Huang Qin Jin Gao | 黄芩浸膏 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
Ckey description of the interaction between compound and target