Target Description

Type Detail
Target ID T39XYV
Protein Name Dickkopf-related protein 1
Uniprot ID O94907
Protein Name Alias Dickkopf-1;  Dkk-1;  hDkk-1;  SK
Gene ID 22943
Gene Symbol DKK1
Gene Alias NA
TTD T56697: Clinical Trial target
Pfam PF04706
GO
1904723:negative regulation of Wnt-Frizzled-LRP5/6 complex assembly

2000096:positive regulation of Wnt signaling pathway, planar cell polarity pathway

0042663:regulation of endodermal cell fate specification

1901296:negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

1904338:regulation of dopaminergic neuron differentiation

0098883:synapse pruning

0002090:regulation of receptor internalization

1902949:positive regulation of tau-protein kinase activity

0039706:co-receptor binding

0043507:positive regulation of JUN kinase activity

0030279:negative regulation of ossification

0007611:learning or memory

0010942:positive regulation of cell death

0045813:positive regulation of Wnt signaling pathway, calcium modulating pathway

0005615:extracellular space

0033137:negative regulation of peptidyl-serine phosphorylation

0090647:modulation of age-related behavioral decline

0042662:negative regulation of mesodermal cell fate specification

0060173:limb development

0010628:positive regulation of gene expression

0050750:low-density lipoprotein particle receptor binding

0008083:growth factor activity

0005886:plasma membrane

0016055:Wnt signaling pathway

0031901:early endosome membrane

0030178:negative regulation of Wnt signaling pathway

1901216:positive regulation of neuron death

0048019:receptor antagonist activity

0005576:extracellular region

0000122:negative regulation of transcription by RNA polymerase II

0060394:negative regulation of pathway-restricted SMAD protein phosphorylation

0032091:negative regulation of protein binding

0090090:negative regulation of canonical Wnt signaling pathway

0090082:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway

0043066:negative regulation of apoptotic process

2000726:negative regulation of cardiac muscle cell differentiation

PDB 5GJE ; 3S8V ; 3SOQ ; 3S2K ; 5FWW
Drugbank NA
KEGG hsa:22943

Related Compounds  (Total: 1)

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C1125
Name: Baicalin


Related Herbs  (Total: 32)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1225 Huai Mi槐米 NASophora japonica
H1227 Huai Zhi槐枝 NASophora japonica
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0527 Tao PeachPrunus persica
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis