HIT-result

Target Description

Type	Detail
Target ID	T07BRZ
Protein Name	E3 ubiquitin-protein ligase UHRF1
Uniprot ID	Q96T88
Protein Name Alias	EC 2.3.2.27; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; hUHRF1; Ubiquitin-like-containing PHD and RING finger domains protein 1
Gene ID	29128
Gene Symbol	UHRF1
Gene Alias	ICBP90; NP95; RNF106
TTD	NA
Pfam	PF02182 ; PF00628 ; PF00240 ; PF12148
GO	0016567:protein ubiquitination 0042802:identical protein binding 0005634:nucleus 0004842:ubiquitin-protein transferase activity 2000373:positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity 0000791:euchromatin 0000987:cis-regulatory region sequence-specific DNA binding 0008327:methyl-CpG binding 0051865:protein autoubiquitination 0010216:maintenance of DNA methylation 0032270:positive regulation of cellular protein metabolic process 0007049:cell cycle 0035064:methylated histone binding 0006511:ubiquitin-dependent protein catabolic process 0000785:chromatin 0006281:DNA repair 0000792:heterochromatin 0005657:replication fork 0010390:histone monoubiquitination 0000122:negative regulation of transcription by RNA polymerase II 0008270:zinc ion binding 0042393:histone binding 0005654:nucleoplasm 0050678:regulation of epithelial cell proliferation 0016574:histone ubiquitination 0044729:hemi-methylated DNA-binding 0061630:ubiquitin protein ligase activity 0031493:nucleosomal histone binding 0045944:positive regulation of transcription by RNA polymerase II 0016363:nuclear matrix
PDB	2LGG ; 5XPI ; 6B9M ; 3DWH ; 2PB7 ; 3DB3 ; 6VED ; 2L3R ; 3DB4 ; 2LGK ; 3ASL ; 3ZVZ ; 4GY5 ; 2FAZ ; 3T6R ; 3ZVY ; 6VCS ; 5YY9 ; 3FL2 ; 4QQD ; 2LGL ; 3SOW ; 3ASK ; 3SOX ; 6IIW ; 5YYA ; 5IAY ; 3SOU ; 3BI7 ; 3SHB ; 5C6D ; 3CLZ
Drugbank	NA
KEGG	hsa:29128

Type

Detail

Target ID

T07BRZ

Protein Name

E3 ubiquitin-protein ligase UHRF1

Uniprot ID

Q96T88

Protein Name Alias

EC 2.3.2.27; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; hUHRF1; Ubiquitin-like-containing PHD and RING finger domains protein 1

Gene ID

29128

Gene Symbol

UHRF1

Gene Alias

ICBP90; NP95; RNF106

TTD

Pfam

PF02182 ; PF00628 ; PF00240 ; PF12148

0016567:protein ubiquitination

0042802:identical protein binding

0005634:nucleus

0004842:ubiquitin-protein transferase activity

2000373:positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

0000791:euchromatin

0000987:cis-regulatory region sequence-specific DNA binding

0008327:methyl-CpG binding

0051865:protein autoubiquitination

0010216:maintenance of DNA methylation

0032270:positive regulation of cellular protein metabolic process

0007049:cell cycle

0035064:methylated histone binding

0006511:ubiquitin-dependent protein catabolic process

0000785:chromatin

0006281:DNA repair

0000792:heterochromatin

0005657:replication fork

0010390:histone monoubiquitination

0000122:negative regulation of transcription by RNA polymerase II

0008270:zinc ion binding

0042393:histone binding

0005654:nucleoplasm

0050678:regulation of epithelial cell proliferation

0016574:histone ubiquitination

0044729:hemi-methylated DNA-binding

0061630:ubiquitin protein ligase activity

0031493:nucleosomal histone binding

0045944:positive regulation of transcription by RNA polymerase II

0016363:nuclear matrix

PDB

2LGG ; 5XPI ; 6B9M ; 3DWH ; 2PB7 ; 3DB3 ; 6VED ; 2L3R ; 3DB4 ; 2LGK ; 3ASL ; 3ZVZ ; 4GY5 ; 2FAZ ; 3T6R ; 3ZVY ; 6VCS ; 5YY9 ; 3FL2 ; 4QQD ; 2LGL ; 3SOW ; 3ASK ; 3SOX ; 6IIW ; 5YYA ; 5IAY ; 3SOU ; 3BI7 ; 3SHB ; 5C6D ; 3CLZ

Drugbank

KEGG

hsa:29128

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 25)