HIT-result

Target Description

Type	Detail
Target ID	T63W0D
Protein Name	DNA damage-inducible transcript 3 protein
Uniprot ID	P35638
Protein Name Alias	DDIT-3; C/EBP zeta; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible protein GADD153
Gene ID	1649
Gene Symbol	DDIT3
Gene Alias	CHOP; CHOP10; GADD153
TTD	NA
Pfam	NA
GO	0006355:regulation of transcription, DNA-templated 0051898:negative regulation of protein kinase B signaling 0032993:protein-DNA complex 0005667:transcription regulator complex 0051091:positive regulation of DNA-binding transcription factor activity 0000976:transcription regulatory region sequence-specific DNA binding 0006974:cellular response to DNA damage stimulus 1990617:CHOP-ATF4 complex 1990442:intrinsic apoptotic signaling pathway in response to nitrosative stress 0043618:regulation of transcription from RNA polymerase II promoter in response to stress 0030968:endoplasmic reticulum unfolded protein response 0009948:anterior/posterior axis specification 0090090:negative regulation of canonical Wnt signaling pathway 0120163:negative regulation of cold-induced thermogenesis 0008134:transcription factor binding 0032713:negative regulation of interleukin-4 production 2001244:positive regulation of intrinsic apoptotic signaling pathway 0032757:positive regulation of interleukin-8 production 0051209:release of sequestered calcium ion into cytosol 0045454:cell redox homeostasis 0032088:negative regulation of NF-kappaB transcription factor activity 0045599:negative regulation of fat cell differentiation 0005829:cytosol 0042594:response to starvation 0007050:cell cycle arrest 1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 0046982:protein heterodimerization activity 0006983:ER overload response 0036488:CHOP-C/EBP complex 0016055:Wnt signaling pathway 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 2000016:negative regulation of determination of dorsal identity 0043433:negative regulation of DNA-binding transcription factor activity 1990622:CHOP-ATF3 complex 0032792:negative regulation of CREB transcription factor activity 0008140:cAMP response element binding protein binding 0032700:negative regulation of interleukin-17 production 0036499:PERK-mediated unfolded protein response 0001955:blood vessel maturation 0005737:cytoplasm 0003677:DNA binding 0045893:positive regulation of transcription, DNA-templated 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 0043525:positive regulation of neuron apoptotic process 0007605:sensory perception of sound 0036500:ATF6-mediated unfolded protein response 1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 0043522:leucine zipper domain binding 0003700:DNA-binding transcription factor activity 0045944:positive regulation of transcription by RNA polymerase II 0042803:protein homodimerization activity 0032689:negative regulation of interferon-gamma production 0005634:nucleus 1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0045892:negative regulation of transcription, DNA-templated 0072655:establishment of protein localization to mitochondrion 0140416:transcription regulator inhibitor activity 0000785:chromatin 0005770:late endosome 0000122:negative regulation of transcription by RNA polymerase II 0034976:response to endoplasmic reticulum stress 0045662:negative regulation of myoblast differentiation 0006986:response to unfolded protein 0010506:regulation of autophagy 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0006357:regulation of transcription by RNA polymerase II
PDB	NA
Drugbank	NA
KEGG	hsa:1649

Type

Detail

Target ID

T63W0D

Protein Name

DNA damage-inducible transcript 3 protein

Uniprot ID

P35638

Protein Name Alias

DDIT-3; C/EBP zeta; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible protein GADD153

Gene ID

1649

Gene Symbol

DDIT3

Gene Alias

CHOP; CHOP10; GADD153

TTD

Pfam

0006355:regulation of transcription, DNA-templated

0051898:negative regulation of protein kinase B signaling

0032993:protein-DNA complex

0005667:transcription regulator complex

0051091:positive regulation of DNA-binding transcription factor activity

0000976:transcription regulatory region sequence-specific DNA binding

0006974:cellular response to DNA damage stimulus

1990617:CHOP-ATF4 complex

1990442:intrinsic apoptotic signaling pathway in response to nitrosative stress

0043618:regulation of transcription from RNA polymerase II promoter in response to stress

0030968:endoplasmic reticulum unfolded protein response

0009948:anterior/posterior axis specification

0090090:negative regulation of canonical Wnt signaling pathway

0120163:negative regulation of cold-induced thermogenesis

0008134:transcription factor binding

0032713:negative regulation of interleukin-4 production

2001244:positive regulation of intrinsic apoptotic signaling pathway

0032757:positive regulation of interleukin-8 production

0051209:release of sequestered calcium ion into cytosol

0045454:cell redox homeostasis

0032088:negative regulation of NF-kappaB transcription factor activity

0045599:negative regulation of fat cell differentiation

0005829:cytosol

0042594:response to starvation

0007050:cell cycle arrest

1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

0046982:protein heterodimerization activity

0006983:ER overload response

0036488:CHOP-C/EBP complex

0016055:Wnt signaling pathway

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

2000016:negative regulation of determination of dorsal identity

0043433:negative regulation of DNA-binding transcription factor activity

1990622:CHOP-ATF3 complex

0032792:negative regulation of CREB transcription factor activity

0008140:cAMP response element binding protein binding

0032700:negative regulation of interleukin-17 production

0036499:PERK-mediated unfolded protein response

0001955:blood vessel maturation

0005737:cytoplasm

0003677:DNA binding

0045893:positive regulation of transcription, DNA-templated

0043161:proteasome-mediated ubiquitin-dependent protein catabolic process

0043525:positive regulation of neuron apoptotic process

0007605:sensory perception of sound

0036500:ATF6-mediated unfolded protein response

1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

0043522:leucine zipper domain binding

0003700:DNA-binding transcription factor activity

0045944:positive regulation of transcription by RNA polymerase II

0042803:protein homodimerization activity

0032689:negative regulation of interferon-gamma production

0005634:nucleus

1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0045892:negative regulation of transcription, DNA-templated

0072655:establishment of protein localization to mitochondrion

0140416:transcription regulator inhibitor activity

0000785:chromatin

0005770:late endosome

0000122:negative regulation of transcription by RNA polymerase II

0034976:response to endoplasmic reticulum stress

0045662:negative regulation of myoblast differentiation

0006986:response to unfolded protein

0010506:regulation of autophagy

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

PDB

Drugbank

KEGG

hsa:1649

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0030	Jiang Pi	姜皮	Ginger peel	Cortex zingiberis
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 27)