Target Description

Type Detail
Target ID T59EBF
Protein Name Breast cancer type 2 susceptibility protein
Uniprot ID P51587
Protein Name Alias Fanconi anemia group D1 protein
Gene ID 675
Gene Symbol BRCA2
Gene Alias FACD;  FANCD1
TTD T15823: Research target
Pfam PF09121 ; PF09169 ; PF09104 ; PF09103 ; PF00634
GO
0005634:nucleus

0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

0005829:cytosol

0001556:oocyte maturation

0048478:replication fork protection

0003697:single-stranded DNA binding

0008022:protein C-terminus binding

0032991:protein-containing complex

0030141:secretory granule

0005813:centrosome

0000800:lateral element

0010225:response to UV-C

0006978:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

1990426:mitotic recombination-dependent replication fork processing

0032465:regulation of cytokinesis

0000724:double-strand break repair via homologous recombination

0042802:identical protein binding

0005654:nucleoplasm

0045893:positive regulation of transcription, DNA-templated

0033600:negative regulation of mammary gland epithelial cell proliferation

0007283:spermatogenesis

0043967:histone H4 acetylation

0051298:centrosome duplication

0007141:male meiosis I

0007420:brain development

0010165:response to X-ray

0001833:inner cell mass cell proliferation

0007569:cell aging

0006289:nucleotide-excision repair

0000722:telomere maintenance via recombination

0008585:female gonad development

0002020:protease binding

0033593:BRCA2-MAGE-D1 complex

0043966:histone H3 acetylation

0010485:H4 histone acetyltransferase activity

0045931:positive regulation of mitotic cell cycle

0010332:response to gamma radiation

0043015:gamma-tubulin binding

0070200:establishment of protein localization to telomere

0006355:regulation of transcription, DNA-templated

0030097:hemopoiesis

0006302:double-strand break repair

0010484:H3 histone acetyltransferase activity

0000781:chromosome, telomeric region

PDB 1N0W ; 6HQU ; 3EU7 ; 6GY2
Drugbank NA
KEGG hsa:675

Related Compounds  (Total: 1)

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C0363
Name: Resveratrol


Related Herbs  (Total: 25)

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H0357 Ren Shen人参 GinsengPanax ginseng
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0416 Shan Shen山参 NAPanax ginseng
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0617 Qian Cao Teng茜草藤 NARubia cordifolia