HIT-result

Target Description

Type	Detail
Target ID	T78PK3
Protein Name	cAMP-dependent protein kinase catalytic subunit alpha
Uniprot ID	P17612
Protein Name Alias	PKA C-alpha; EC 2.7.11.11
Gene ID	5566
Gene Symbol	PRKACA
Gene Alias	PKACA
TTD	T20669: Patented target
Pfam	PF00069
GO	0004672:protein kinase activity 0106310:protein serine kinase activity 0004674:protein serine/threonine kinase activity 0019904:protein domain specific binding 0002027:regulation of heart rate 0055117:regulation of cardiac muscle contraction 0034380:high-density lipoprotein particle assembly 0018105:peptidyl-serine phosphorylation 0001843:neural tube closure 0019901:protein kinase binding 0007596:blood coagulation 0044853:plasma membrane raft 0043197:dendritic spine 0001707:mesoderm formation 0000086:G2/M transition of mitotic cell cycle 0071333:cellular response to glucose stimulus 0031588:nucleotide-activated protein kinase complex 0005813:centrosome 0046777:protein autophosphorylation 0034237:protein kinase A regulatory subunit binding 0048240:sperm capacitation 0005829:cytosol 0046827:positive regulation of protein export from nucleus 0097711:ciliary basal body-plasma membrane docking 0004679:AMP-activated protein kinase activity 0003091:renal water homeostasis 0005737:cytoplasm 2000810:regulation of bicellular tight junction assembly 0006397:mRNA processing 0005524:ATP binding 0048471:perinuclear region of cytoplasm 0018107:peptidyl-threonine phosphorylation 0001669:acrosomal vesicle 0071872:cellular response to epinephrine stimulus 0006468:protein phosphorylation 0005739:mitochondrion 0034199:activation of protein kinase A activity 0061136:regulation of proteasomal protein catabolic process 0036126:sperm flagellum 0016241:regulation of macroautophagy 0005634:nucleus 0035584:calcium-mediated signaling using intracellular calcium source 0007268:chemical synaptic transmission 0106311:protein threonine kinase activity 0031625:ubiquitin protein ligase binding 0010881:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 0002223:stimulatory C-type lectin receptor signaling pathway 0004691:cAMP-dependent protein kinase activity 0043393:regulation of protein binding 0005952:cAMP-dependent protein kinase complex 0010737:protein kinase A signaling 0071158:positive regulation of cell cycle arrest 0002862:negative regulation of inflammatory response to antigenic stimulus 0086064:cell communication by electrical coupling involved in cardiac conduction 0030145:manganese ion binding 0016020:membrane 0045667:regulation of osteoblast differentiation 0016607:nuclear speck 0071377:cellular response to glucagon stimulus 1901621:negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 0060314:regulation of ryanodine-sensitive calcium-release channel activity 0010389:regulation of G2/M transition of mitotic cell cycle 0070062:extracellular exosome 0002250:adaptive immune response 0051480:regulation of cytosolic calcium ion concentration 0050804:modulation of chemical synaptic transmission 0004712:protein serine/threonine/tyrosine kinase activity 0000287:magnesium ion binding 0070613:regulation of protein processing 1903779:regulation of cardiac conduction 0071374:cellular response to parathyroid hormone stimulus 0097225:sperm midpiece 0097546:ciliary base 0005654:nucleoplasm 0034605:cellular response to heat 0034704:calcium channel complex 0019221:cytokine-mediated signaling pathway 0031594:neuromuscular junction
PDB	6WJF ; 3AMA ; 3OOG ; 3OXT ; 3MVJ ; 4WB8 ; 4WB7 ; 4WB5 ; 5IZF ; 3NX8 ; 3OVV ; 4UJ2 ; 3POO ; 3L9N ; 4UJ9 ; 3AMB ; 3L9M ; 5IZJ ; 4AE6 ; 4UJ1 ; 4UJA ; 2GU8 ; 6QJ7 ; 6BYS ; 3AGM ; 4AE9 ; 4UJB ; 5UZK ; 6BYR ; 3P0M ; 6NO7 ; 3L9L ; 6C0U ; 5N23 ; 5BX7 ; 3OWP ; 6WJG ; 5BX6 ; 5J5X ; 6FRX ; 3VQH ; 4WB6 ; 3AGL
Drugbank	DB07859 ; DB08070 ; DB02611 ; DB01919 ; DB08148 ; DB02482 ; DB08231 ; DB03374 ; DB12010 ; DB04522 ; DB07458 ; DB07854 ; DB01940 ; DB07124 ; DB07857 ; DB07107 ; DB08568 ; DB08150 ; DB08756 ; DB08569 ; DB07204 ; DB07876 ; DB07235 ; DB07995 ; DB07858 ; DB07947 ; DB07856 ; DB08149 ; DB04707 ; DB08073 ; DB06959 ; DB08113 ; DB07855 ; DB04098 ; DB08162 ; DB07997 ; DB07583 ; DB07996 ; DB04530 ; DB07860 ; DB08114 ; DB08846 ; DB02155 ; DB06977
KEGG	hsa:5566

Type

Detail

Target ID

T78PK3

Protein Name

cAMP-dependent protein kinase catalytic subunit alpha

Uniprot ID

P17612

Protein Name Alias

PKA C-alpha; EC 2.7.11.11

Gene ID

5566

Gene Symbol

PRKACA

Gene Alias

PKACA

TTD

T20669: Patented target

Pfam

PF00069

0004672:protein kinase activity

0106310:protein serine kinase activity

0004674:protein serine/threonine kinase activity

0019904:protein domain specific binding

0002027:regulation of heart rate

0055117:regulation of cardiac muscle contraction

0034380:high-density lipoprotein particle assembly

0018105:peptidyl-serine phosphorylation

0001843:neural tube closure

0019901:protein kinase binding

0007596:blood coagulation

0044853:plasma membrane raft

0043197:dendritic spine

0001707:mesoderm formation

0000086:G2/M transition of mitotic cell cycle

0071333:cellular response to glucose stimulus

0031588:nucleotide-activated protein kinase complex

0005813:centrosome

0046777:protein autophosphorylation

0034237:protein kinase A regulatory subunit binding

0048240:sperm capacitation

0005829:cytosol

0046827:positive regulation of protein export from nucleus

0097711:ciliary basal body-plasma membrane docking

0004679:AMP-activated protein kinase activity

0003091:renal water homeostasis

0005737:cytoplasm

2000810:regulation of bicellular tight junction assembly

0006397:mRNA processing

0005524:ATP binding

0048471:perinuclear region of cytoplasm

0018107:peptidyl-threonine phosphorylation

0001669:acrosomal vesicle

0071872:cellular response to epinephrine stimulus

0006468:protein phosphorylation

0005739:mitochondrion

0034199:activation of protein kinase A activity

0061136:regulation of proteasomal protein catabolic process

0036126:sperm flagellum

0016241:regulation of macroautophagy

0005634:nucleus

0035584:calcium-mediated signaling using intracellular calcium source

0007268:chemical synaptic transmission

0106311:protein threonine kinase activity

0031625:ubiquitin protein ligase binding

0010881:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

0002223:stimulatory C-type lectin receptor signaling pathway

0004691:cAMP-dependent protein kinase activity

0043393:regulation of protein binding

0005952:cAMP-dependent protein kinase complex

0010737:protein kinase A signaling

0071158:positive regulation of cell cycle arrest

0002862:negative regulation of inflammatory response to antigenic stimulus

0086064:cell communication by electrical coupling involved in cardiac conduction

0030145:manganese ion binding

0016020:membrane

0045667:regulation of osteoblast differentiation

0016607:nuclear speck

0071377:cellular response to glucagon stimulus

1901621:negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

0060314:regulation of ryanodine-sensitive calcium-release channel activity

0010389:regulation of G2/M transition of mitotic cell cycle

0070062:extracellular exosome

0002250:adaptive immune response

0051480:regulation of cytosolic calcium ion concentration

0050804:modulation of chemical synaptic transmission

0004712:protein serine/threonine/tyrosine kinase activity

0000287:magnesium ion binding

0070613:regulation of protein processing

1903779:regulation of cardiac conduction

0071374:cellular response to parathyroid hormone stimulus

0097225:sperm midpiece

0097546:ciliary base

0005654:nucleoplasm

0034605:cellular response to heat

0034704:calcium channel complex

0019221:cytokine-mediated signaling pathway

0031594:neuromuscular junction

PDB

6WJF ; 3AMA ; 3OOG ; 3OXT ; 3MVJ ; 4WB8 ; 4WB7 ; 4WB5 ; 5IZF ; 3NX8 ; 3OVV ; 4UJ2 ; 3POO ; 3L9N ; 4UJ9 ; 3AMB ; 3L9M ; 5IZJ ; 4AE6 ; 4UJ1 ; 4UJA ; 2GU8 ; 6QJ7 ; 6BYS ; 3AGM ; 4AE9 ; 4UJB ; 5UZK ; 6BYR ; 3P0M ; 6NO7 ; 3L9L ; 6C0U ; 5N23 ; 5BX7 ; 3OWP ; 6WJG ; 5BX6 ; 5J5X ; 6FRX ; 3VQH ; 4WB6 ; 3AGL

Drugbank

DB07859 ; DB08070 ; DB02611 ; DB01919 ; DB08148 ; DB02482 ; DB08231 ; DB03374 ; DB12010 ; DB04522 ; DB07458 ; DB07854 ; DB01940 ; DB07124 ; DB07857 ; DB07107 ; DB08568 ; DB08150 ; DB08756 ; DB08569 ; DB07204 ; DB07876 ; DB07235 ; DB07995 ; DB07858 ; DB07947 ; DB07856 ; DB08149 ; DB04707 ; DB08073 ; DB06959 ; DB08113 ; DB07855 ; DB04098 ; DB08162 ; DB07997 ; DB07583 ; DB07996 ; DB04530 ; DB07860 ; DB08114 ; DB08846 ; DB02155 ; DB06977

KEGG

hsa:5566

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 28)