HIT-result

Target Description

Type	Detail
Target ID	T81KAJ
Protein Name	X-ray repair cross-complementing protein 6
Uniprot ID	P12956
Protein Name Alias	EC 3.6.4.-; EC 4.2.99.-; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
Gene ID	2547
Gene Symbol	XRCC6
Gene Alias	G22P1
TTD	NA
Pfam	PF02735 ; PF03731 ; PF02037 ; PF03730
GO	0030332:cyclin binding 0032993:protein-DNA complex 0005667:transcription regulator complex 0003690:double-stranded DNA binding 0000976:transcription regulatory region sequence-specific DNA binding 0032991:protein-containing complex 0003684:damaged DNA binding 0005524:ATP binding 0006266:DNA ligation 0048660:regulation of smooth muscle cell proliferation 0043564:Ku70:Ku80 complex 0005730:nucleolus 0016020:membrane 0006303:double-strand break repair via nonhomologous end joining 0008022:protein C-terminus binding 0007420:brain development 0071480:cellular response to gamma radiation 0000781:chromosome, telomeric region 0005829:cytosol 0042162:telomeric DNA binding 0008094:DNA-dependent ATPase activity 0005576:extracellular region 0044877:protein-containing complex binding 0075713:establishment of integrated proviral latency 0070419:nonhomologous end joining complex 0002218:activation of innate immune response 0045087:innate immune response 0005654:nucleoplasm 1904813:ficolin-1-rich granule lumen 0051575:5'-deoxyribose-5-phosphate lyase activity 0003677:DNA binding 0097680:double-strand break repair via classical nonhomologous end joining 0045893:positive regulation of transcription, DNA-templated 0003723:RNA binding 0071481:cellular response to X-ray 0043312:neutrophil degranulation 0045944:positive regulation of transcription by RNA polymerase II 0005634:nucleus 0003678:DNA helicase activity 0034774:secretory granule lumen 0000723:telomere maintenance 0045892:negative regulation of transcription, DNA-templated 0045621:positive regulation of lymphocyte differentiation 0071475:cellular hyperosmotic salinity response 0045860:positive regulation of protein kinase activity 0032481:positive regulation of type I interferon production 0006310:DNA recombination 0000783:nuclear telomere cap complex
PDB	7K1K ; 1JEQ ; 7K1N ; 5Y3R ; 1JJR ; 6ERF ; 6ERG ; 3RZX ; 7K1J ; 6ZHA ; 6ZHE ; 6ERH ; 1JEY
Drugbank	NA
KEGG	hsa:2547

Type

Detail

Target ID

T81KAJ

Protein Name

X-ray repair cross-complementing protein 6

Uniprot ID

P12956

Protein Name Alias

EC 3.6.4.-; EC 4.2.99.-; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6

Gene ID

2547

Gene Symbol

XRCC6

Gene Alias

G22P1

TTD

Pfam

PF02735 ; PF03731 ; PF02037 ; PF03730

0030332:cyclin binding

0032993:protein-DNA complex

0005667:transcription regulator complex

0003690:double-stranded DNA binding

0000976:transcription regulatory region sequence-specific DNA binding

0032991:protein-containing complex

0003684:damaged DNA binding

0005524:ATP binding

0006266:DNA ligation

0048660:regulation of smooth muscle cell proliferation

0043564:Ku70:Ku80 complex

0005730:nucleolus

0016020:membrane

0006303:double-strand break repair via nonhomologous end joining

0008022:protein C-terminus binding

0007420:brain development

0071480:cellular response to gamma radiation

0000781:chromosome, telomeric region

0005829:cytosol

0042162:telomeric DNA binding

0008094:DNA-dependent ATPase activity

0005576:extracellular region

0044877:protein-containing complex binding

0075713:establishment of integrated proviral latency

0070419:nonhomologous end joining complex

0002218:activation of innate immune response

0045087:innate immune response

0005654:nucleoplasm

1904813:ficolin-1-rich granule lumen

0051575:5'-deoxyribose-5-phosphate lyase activity

0003677:DNA binding

0097680:double-strand break repair via classical nonhomologous end joining

0045893:positive regulation of transcription, DNA-templated

0003723:RNA binding

0071481:cellular response to X-ray

0043312:neutrophil degranulation

0045944:positive regulation of transcription by RNA polymerase II

0005634:nucleus

0003678:DNA helicase activity

0034774:secretory granule lumen

0000723:telomere maintenance

0045892:negative regulation of transcription, DNA-templated

0045621:positive regulation of lymphocyte differentiation

0071475:cellular hyperosmotic salinity response

0045860:positive regulation of protein kinase activity

0032481:positive regulation of type I interferon production

0006310:DNA recombination

0000783:nuclear telomere cap complex

PDB

7K1K ; 1JEQ ; 7K1N ; 5Y3R ; 1JJR ; 6ERF ; 6ERG ; 3RZX ; 7K1J ; 6ZHA ; 6ZHE ; 6ERH ; 1JEY

Drugbank

KEGG

hsa:2547

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 25)