Compound Description
| ID: C0881 | Common name: Aloe-Emodin |
| IUPAC: 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione | CAS: NA |
| Chembl ID: CHEMBL40275 | Pubchem ID: CID:10207 |
| Formula: C15H10O5 | TCM-ID: TCMC663 |
| Smiles: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO | |
| Alias:
NA
|
Structure:
|
Related Targets (Total: 22)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
A | 1 Reference(s) |
| T13Z69 | Solute carrier family 22 member 6 | SLC22A6 |
Q4U2R8 |
A | 1 Reference(s) |
| T50PQ4 | Solute carrier family 22 member 8 | SLC22A8 |
Q8TCC7 |
A | 1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
B | 1 Reference(s) |
| T09KQF | Proliferating cell nuclear antigen | PCNA |
P12004 |
B | 1 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
B | 1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
B | 1 Reference(s) |
| T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
B | 1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
B | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
B | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
B | 1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
B | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
B | 1 Reference(s) |
| T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
B | 1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
B | 1 Reference(s) |
| T86UXL | Cyclin-A2 | CCNA2 |
P20248 |
C | 1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
C | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
C | 1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
C | 1 Reference(s) |
| T62Y4H | Protein kinase C epsilon type | PRKCE |
Q02156 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 16)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1028 | Fan Xie Ye | 番泻叶 | Narrowleaf senna leaf | Cassia angustifolia |
| H0298 | Niu Xi Xi | 牛西西 | Patience dock | Rumex patientia |
| H0540 | Tian Ji Huang | 田基黄 | all - grass of japanese st. johnswort | Grangea maderaspatana |
| H0725 | Yang Xie | 洋泻 | sennoside | Cassia angustifolia |
| H0685 | Xuan Cao Gen | 萱草根 | Orange daylily | Hemerocallis fulva |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H0102 | Jue Ming Zi | 决明子 | Sickle senna seed | Cassia tora |
| H1000 | Dong Gua Zi | 冬瓜子 | Chinese waxgourd seed | Benincasa hispida |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0998 | Dong Gua Pi | 冬瓜皮 | Chinese waxgourd peel | Benincasa hispida |
| H0749 | Yin Xing Cao | 阴行草 | Chinese siphonostegia | Siphonostegia chinensis |
Ckey description of the interaction between compound and target