Herb Description
| Herb ID: H1028 | Chinese Character: 番泻叶 |
| English Name: Narrowleaf senna leaf | Latin Name: Cassia angustifolia |
| Chinese Pin Yin : Fan Xie Ye | TCM-ID: TCMH560 |
| Therapeutic Function in Chinese : 泻下 | Therapeutic Function in English: Purging |
| Herb Function: Purge feces downward | |
Related Targets (Total: 63)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
1 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
1 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
2 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
4 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
3 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
3 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
2 Reference(s) |
| T14JSQ | Baculoviral IAP repeat-containing protein 2 | BIRC2 |
Q13490 |
1 Reference(s) |
| T70YKV | Baculoviral IAP repeat-containing protein 3 | BIRC3 |
Q13489 |
1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
2 Reference(s) |
| T40B7E | Calcium uniporter protein, mitochondrial | MCU |
Q8NE86 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
1 Reference(s) |
| T97UTI | 6-phosphogluconate dehydrogenase, decarboxylating | PGD |
P52209 |
2 Reference(s) |
| T13Z69 | Solute carrier family 22 member 6 | SLC22A6 |
Q4U2R8 |
1 Reference(s) |
| T50PQ4 | Solute carrier family 22 member 8 | SLC22A8 |
Q8TCC7 |
1 Reference(s) |
| T92Q77 | Type I iodothyronine deiodinase | DIO1 |
P49895 |
1 Reference(s) |
| T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
3 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
2 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
1 Reference(s) |
| T48XM4 | Glutathione S-transferase Mu 2 | GSTM2 |
P28161 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
1 Reference(s) |
| T87WYU | Glutathione S-transferase Mu 1 | GSTM1 |
P09488 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
2 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
2 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
2 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
1 Reference(s) |
| T41INV | Nuclear receptor subfamily 1 group I member 3 | NR1I3 |
Q14994 |
1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
| T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
1 Reference(s) |
| T54OSZ | Pleckstrin | PLEK |
P08567 |
2 Reference(s) |
| T63FNY | NSFL1 cofactor p47 | NSFL1C |
Q9UNZ2 |
2 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
1 Reference(s) |
| T09KQF | Proliferating cell nuclear antigen | PCNA |
P12004 |
1 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
1 Reference(s) |
| T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
1 Reference(s) |
| T07VO1 | Steroid hormone receptor ERR1 | ESRRA |
P11474 |
2 Reference(s) |
| T99ARN | Forkhead box protein P3 | FOXP3 |
Q9BZS1 |
1 Reference(s) |
| T18DUA | Tight junction protein ZO-1 | TJP1 |
Q07157 |
1 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T10IWJ | Bone morphogenetic protein receptor type-2 | BMPR2 |
Q13873 |
1 Reference(s) |
| T75PC7 | NA | MIR21 |
NA |
1 Reference(s) |
| T14DX3 | Ribosomal protein S6 kinase alpha-3 | RPS6KA3 |
P51812 |
1 Reference(s) |
| T66WWM | Claudin-2 | CLDN2 |
P57739 |
1 Reference(s) |
| T86UXL | Cyclin-A2 | CCNA2 |
P20248 |
1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
1 Reference(s) |
| T62Y4H | Protein kinase C epsilon type | PRKCE |
Q02156 |
1 Reference(s) |
| T48YPL | Aquaporin-3 | AQP3 |
Q92482 |
1 Reference(s) |
Related Compounds (Total: 4)
key description of the interaction between compound and target