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Compound Description

ID:   C0164 Common name:   Kaempferol
IUPAC:  3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one CAS:  CAS:520-18-3
Chembl ID:   CHEMBL150 Pubchem ID:   CID:5280863
Formula:  C15H10O6 TCM-ID:  TCMC1429
Smiles:  C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
Alias:

Flavone, 3,4',5,7-tetrahydroxy-;

3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;

3,4',5,7-Tetrahydroxyflavone;

3,5,7,4'-Tetrahydroxyflavone;

3'-Deoxyquercetin;

5,7,4'-Trihydroxyflavonol;

C.I. 75640;

CSU 2056;

CSU-2056;

Indigo Yellow;

Kaemferol;

Kaempferol;

Kaempherol;

Kampcetin;

Kempferol;

NSC 407289;

NSC 656277;

Nimbecetin;

Pelargidenolon;

Pelargidenon;

Populnetin;

Rhamnolutein;

Rhamnolutin;

Robigenin;

Swartziol;

Trifolitin
Structure:

Related Targets  (Total: 44)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T02QBS Cytochrome P450 1A2CYP1A2 P05177
 A 1 Reference(s)
T69XVX Cytochrome P450 1B1CYP1B1 Q16678
 A 1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
 A 2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
 A 4 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
 A 2 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
 A 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
 A 3 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
 A 2 Reference(s)
T14JSQ Baculoviral IAP repeat-containing protein 2BIRC2 Q13490
 A 1 Reference(s)
T70YKV Baculoviral IAP repeat-containing protein 3BIRC3 Q13489
 A 1 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
 A 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 A 1 Reference(s)
T40B7E Calcium uniporter protein, mitochondrialMCU Q8NE86
 A 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
 A 1 Reference(s)
T92Q77 Type I iodothyronine deiodinaseDIO1 P49895
 B 1 Reference(s)
T67HAF Signal transducer and activator of transcription 1-alpha/betaSTAT1 P42224
 B 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
 B 3 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
 B 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
 B 1 Reference(s)
T48XM4 Glutathione S-transferase Mu 2GSTM2 P28161
 B 1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
 B 1 Reference(s)
T87WYU Glutathione S-transferase Mu 1GSTM1 P09488
 B 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
 B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
 B 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
 B 2 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
 B 1 Reference(s)
T50SX0 Nuclear receptor subfamily 1 group I member 2NR1I2 O75469
 B 1 Reference(s)
T41INV Nuclear receptor subfamily 1 group I member 3NR1I3 Q14994
 B 1 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
 B 1 Reference(s)
T24U57 E-selectinSELE P16581
 B 1 Reference(s)
T87DEX Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseXDH P47989
 B 1 Reference(s)
T54OSZ PleckstrinPLEK P08567
 B 2 Reference(s)
T63FNY NSFL1 cofactor p47NSFL1C Q9UNZ2
 B 2 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 C 1 Reference(s)
T07VO1 Steroid hormone receptor ERR1ESRRA P11474
 C 2 Reference(s)
T99ARN Forkhead box protein P3FOXP3 Q9BZS1
 C 1 Reference(s)
T18DUA Tight junction protein ZO-1TJP1 Q07157
 C 1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
 C 1 Reference(s)
T09BRP NAPKB_RS07820 NA
 C 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
 C 1 Reference(s)
T10IWJ Bone morphogenetic protein receptor type-2BMPR2 Q13873
 C 1 Reference(s)
T75PC7 NAMIR21 NA
 C 1 Reference(s)
T14DX3 Ribosomal protein S6 kinase alpha-3RPS6KA3 P51812
 C 1 Reference(s)
T66WWM Claudin-2CLDN2 P57739
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 188)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0978 Di Tao Hua地桃花 Rose mallowUrena lobata
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H1227 Huai Zhi槐枝 NASophora japonica
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0725 Yang Xie洋泻 sennosideCassia angustifolia
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0734 Ye Xia Zhu叶下珠 Common leafflowerPhyllanthus urinaria
H1202 Hu Huang Lian胡黄连 PicrorhizaPicrorhiza kurrooa
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0440 Sheng Di Hong Jing Tian圣地红景天 Integripetal rhodiolaRhodiola sacra
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0938 Da Suan大蒜 GarlicAllium sativum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0425 Shan Zhi Ma山芝麻 Narrowleaf screwtreeHelicteres angustifolia
H0415 Shan Nai山柰 Galanga resurrectionlilyKaempferia galanga
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0802 Zhi Geng枳梗 NACitrus aurantium
H0716 Yang Cong洋葱 Common onionAllium cepa
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0871 Chuan Duan川断 TeaselsDipsacus asper
H1246 Huang Pi Ye黄皮叶 Chinese wampee leafClausena lansium
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0541 Cang Qie Gen藏茄根 Tibetan eggplant rootAnisodus tanguticus
H0357 Ren Shen人参 GinsengPanax ginseng
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0015 Ji Xing Zi急性子 Garden balsam seedImpatiens balsamina
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0014 Bai Rui Cao百蕊草 Chinese bastardtoadflaxThesium chinense
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1061 Bai He百合 LilyLilium brownii
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0470 Shi Ye柿叶 Persimmon leafDiospyros kaki
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H0301 Ou藕 Hindu lotus large rhizomeNelumbo nucifera
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0772 Yue Ji Hua月季花 Chinese roseRosa chinensis
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0793 Zhao Shan Bai照山白 Manchurian rhododendronRhododendron micranthum
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H1046 Feng Xian Tou Gu Cao凤仙透骨草 Spotted snapweedImpatiens balsamina
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0190 Lv Dou绿豆 Common sainfoinOnobrychis viciifolia
H1187 Hong Guan Yao红管药 NAAster ageratoides
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0345 Qing Guo Tan青果炭 white oliveCanarium album
H0717 Yang Cong Tou洋葱头 Common onionAllium cepa
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0045 Jin Fei Cao金沸草 Japanese inulaInula japonica
H0413 Shan Lang Dang山莨菪 NAAnisodus tanguticus
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0120 Ban Bian Qi半边旗 pinnated brake herbPteris semipinnata
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H1028 Fan Xie Ye番泻叶 Narrowleaf senna leafCassia angustifolia
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0411 Shan Ku Mai山苦荬 China ixerisIxeris chinensis
H0612 Cao Shan Hu Jin Gao草珊瑚浸膏 NASarcandra glabra
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0416 Shan Shen山参 NAPanax ginseng
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0426 Shan Zhi Ma Gan Jin Gao山芝麻干浸膏 Narrowleaf screwtreeHelicteres angustifolia
H0115 Kuan Dong Hua款冬花 Common coltsfootTussilago farfara
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1188 Hong Hua红花 SafflowerCarthamus tinctorius
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H1223 Huai Hun Cao还魂草 NAAster tataricus
H1082 Gan Lan橄榄 CabbageCanarium album
H0591 Wei Ling Cai委陵菜 Chinese cinquefoilPotentilla chinensis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0902 Chun Pi椿皮 Ailanthus bark, tree of heaven barkAilanthi cortex
H0468 Shi Wei石韦 Japanese felt fern frondPyrrosia lingua
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0453 Shi Di柿蒂 Persimmon persistent calyxDiospyros kaki
H1045 Feng Xian Hua凤仙花 Spotted snapweedImpatiens balsamina
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0498 Si Ji Cai四季菜 Ghostplant wormwoodArtemisia lactiflora
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H1189 Hong Jing Tian红景天 all - grass of rhodiolaRadix et rhizoma rhodiolae
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0162 Long Dan龙胆 Rough gentianGentiana scabra
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0798 Zhen Zhu Cao珍珠草 chamber bitterPhyllanthus urinaria
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H1232 Huang Cao Wu黄草乌 NAAconitum vilmorinianum
H0163 Long Dan Jin Gao龙胆浸膏 Rough gentianGentiana scabra
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H1225 Huai Mi槐米 NASophora japonica
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0128 Lao Guan Cao老鹳草 Wilford cranesbillGeranium wilfordii
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0658 Xiao Fan Tian Hua肖梵天花 CaesarweedUrena lobata
H0344 Qing Guo青果 OliveCanarium album
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0377 San Ling三棱 Common burreedSparganium stoloniferum
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0730 Ye Ma Zhui野马追 NAEupatorium lindleyanum
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H0243 Mi Kuan Dong Hua蜜款冬花 Common coltsfootTussilago farfara
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0083 Jiu Jie Cha九节茶 Glabrous sarcandraSarcandra glabra
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0288 Niu Bang Cao牛蒡草 greater burdockArctium lappa
H0696 Ya Jiao Ai鸭脚艾 Ghostplant wormwoodArtemisia lactiflora
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus

Ckey description of the interaction between compound and target


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