Target Description

Type Detail
Target ID T96L4T
Protein Name Krueppel-like factor 4
Uniprot ID O43474
Protein Name Alias Epithelial zinc finger protein EZF;  Gut-enriched krueppel-like factor
Gene ID 9314
Gene Symbol KLF4
Gene Alias EZF;  GKLF
TTD T81916: Clinical Trial target
Pfam PF00096
GO
1902895:positive regulation of pri-miRNA transcription by RNA polymerase II

0035014:phosphatidylinositol 3-kinase regulator activity

0001221:transcription coregulator binding

0006351:transcription, DNA-templated

0016525:negative regulation of angiogenesis

0070301:cellular response to hydrogen peroxide

0014067:negative regulation of phosphatidylinositol 3-kinase signaling

0031077:post-embryonic camera-type eye development

0060761:negative regulation of response to cytokine stimulus

0071409:cellular response to cycloheximide

2000134:negative regulation of G1/S transition of mitotic cell cycle

0000791:euchromatin

0045429:positive regulation of nitric oxide biosynthetic process

0051973:positive regulation of telomerase activity

0000987:cis-regulatory region sequence-specific DNA binding

0009913:epidermal cell differentiation

1904798:positive regulation of core promoter binding

0090051:negative regulation of cell migration involved in sprouting angiogenesis

0120222:regulation of blastocyst development

0035019:somatic stem cell population maintenance

0032270:positive regulation of cellular protein metabolic process

0008285:negative regulation of cell population proliferation

0045892:negative regulation of transcription, DNA-templated

2000342:negative regulation of chemokine (C-X-C motif) ligand 2 production

0045444:fat cell differentiation

0048662:negative regulation of smooth muscle cell proliferation

0019827:stem cell population maintenance

0005737:cytoplasm

0001085:RNA polymerase II transcription factor binding

1903672:positive regulation of sprouting angiogenesis

0001010:RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0060070:canonical Wnt signaling pathway

0010628:positive regulation of gene expression

0014740:negative regulation of muscle hyperplasia

0051898:negative regulation of protein kinase B signaling

0046985:positive regulation of hemoglobin biosynthetic process

1904998:negative regulation of leukocyte adhesion to arterial endothelial cell

0000785:chromatin

1990841:promoter-specific chromatin binding

0032717:negative regulation of interleukin-8 production

0000976:transcription regulatory region sequence-specific DNA binding

0010629:negative regulation of gene expression

0071499:cellular response to laminar fluid shear stress

0050728:negative regulation of inflammatory response

0070373:negative regulation of ERK1 and ERK2 cascade

0048730:epidermis morphogenesis

0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0032088:negative regulation of NF-kappaB transcription factor activity

0005667:transcription regulator complex

1901653:cellular response to peptide

0071363:cellular response to growth factor stimulus

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0045893:positive regulation of transcription, DNA-templated

0071300:cellular response to retinoic acid

0007500:mesodermal cell fate determination

0008270:zinc ion binding

0003700:DNA-binding transcription factor activity

0000122:negative regulation of transcription by RNA polymerase II

0048679:regulation of axon regeneration

0006357:regulation of transcription by RNA polymerase II

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0005654:nucleoplasm

1990837:sequence-specific double-stranded DNA binding

0002357:defense response to tumor cell

0034115:negative regulation of heterotypic cell-cell adhesion

0045595:regulation of cell differentiation

1990830:cellular response to leukemia inhibitory factor

0045944:positive regulation of transcription by RNA polymerase II

0042826:histone deacetylase binding

0008013:beta-catenin binding

0035166:post-embryonic hemopoiesis

0051247:positive regulation of protein metabolic process

PDB NA
Drugbank NA
KEGG hsa:9314

Related Compounds  (Total: 1)

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C0363
Name: Resveratrol


Related Herbs  (Total: 25)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0416 Shan Shen山参 NAPanax ginseng
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0357 Ren Shen人参 GinsengPanax ginseng