Target Description

Type Detail
Target ID T20W1O
Protein Name C-C chemokine receptor type 2
Uniprot ID P41597
Protein Name Alias C-C CKR-2;  CC-CKR-2;  CCR-2;  CCR2;  Monocyte chemoattractant protein 1 receptor;  MCP-1-R;  CD antigen CD192
Gene ID 729230
Gene Symbol CCR2
Gene Alias CMKBR2
TTD T89988: Clinical Trial target
Pfam PF00001
GO
0070098:chemokine-mediated signaling pathway

2000464:positive regulation of astrocyte chemotaxis

0002827:positive regulation of T-helper 1 type immune response

0002829:negative regulation of type 2 immune response

0016021:integral component of membrane

0120162:positive regulation of cold-induced thermogenesis

0030425:dendrite

0007204:positive regulation of cytosolic calcium ion concentration

0090026:positive regulation of monocyte chemotaxis

0043025:neuronal cell body

0001974:blood vessel remodeling

0032760:positive regulation of tumor necrosis factor production

0045580:regulation of T cell differentiation

0007186:G protein-coupled receptor signaling pathway

1904783:positive regulation of NMDA glutamate receptor activity

2000412:positive regulation of thymocyte migration

0060326:cell chemotaxis

0005829:cytosol

2000473:positive regulation of hematopoietic stem cell migration

0009611:response to wounding

0042802:identical protein binding

0016493:C-C chemokine receptor activity

0009897:external side of plasma membrane

0002407:dendritic cell chemotaxis

0032729:positive regulation of interferon-gamma production

0032743:positive regulation of interleukin-2 production

0007194:negative regulation of adenylate cyclase activity

0006968:cellular defense response

0005886:plasma membrane

0005737:cytoplasm

0019725:cellular homeostasis

0043204:perikaryon

0035705:T-helper 17 cell chemotaxis

0005887:integral component of plasma membrane

0016525:negative regulation of angiogenesis

0010574:regulation of vascular endothelial growth factor production

0031727:CCR2 chemokine receptor binding

0051968:positive regulation of synaptic transmission, glutamatergic

0048471:perinuclear region of cytoplasm

0090594:inflammatory response to wounding

0046641:positive regulation of alpha-beta T cell proliferation

0050729:positive regulation of inflammatory response

0006955:immune response

2000439:positive regulation of monocyte extravasation

0019221:cytokine-mediated signaling pathway

0006874:cellular calcium ion homeostasis

0002724:regulation of T cell cytokine production

0090265:positive regulation of immune complex clearance by monocytes and macrophages

0019233:sensory perception of pain

0006935:chemotaxis

0050870:positive regulation of T cell activation

2000451:positive regulation of CD8-positive, alpha-beta T cell extravasation

0006954:inflammatory response

0035696:monocyte extravasation

0007259:receptor signaling pathway via JAK-STAT

1905517:macrophage migration

0043310:negative regulation of eosinophil degranulation

0016032:viral process

0019722:calcium-mediated signaling

0004950:chemokine receptor activity

0019957:C-C chemokine binding

0010820:positive regulation of T cell chemotaxis

0050727:regulation of inflammatory response

PDB 2MLQ ; 1KAD ; 2MLO ; 1KP1 ; 5T1A
Drugbank DB12520 ; DB05130 ; DB05159
KEGG hsa:729230

Related Compounds  (Total: 2)

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C0350
Name: Pyroglutamic Acid
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C0363
Name: Resveratrol


Related Herbs  (Total: 32)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0357 Ren Shen人参 GinsengPanax ginseng
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0339 Qing Dai青黛 Natural indigoIndigo naturalis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0416 Shan Shen山参 NAPanax ginseng
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin