HIT-result

Target Description

Type	Detail
Target ID	T01Z6D
Protein Name	Leukotriene A-4 hydrolase
Uniprot ID	P09960
Protein Name Alias	LTA-4 hydrolase; EC 3.3.2.6; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H; EC 3.4.11.4
Gene ID	4048
Gene Symbol	LTA4H
Gene Alias	LTA4
TTD	T03691: Successful target
Pfam	PF01433 ; PF09127
GO	0005634:nucleus 0070062:extracellular exosome 0006691:leukotriene metabolic process 0070006:metalloaminopeptidase activity 0043171:peptide catabolic process 0044267:cellular protein metabolic process 0004177:aminopeptidase activity 0004463:leukotriene-A4 hydrolase activity 0005829:cytosol 1904724:tertiary granule lumen 0045148:tripeptide aminopeptidase activity 0042759:long-chain fatty acid biosynthetic process 0043312:neutrophil degranulation 0003723:RNA binding 0005576:extracellular region 0008233:peptidase activity 0008270:zinc ion binding 0005654:nucleoplasm 1904813:ficolin-1-rich granule lumen 0004301:epoxide hydrolase activity 0019370:leukotriene biosynthetic process
PDB	3CHO ; 5NIA ; 4R7L ; 1GW6 ; 6ENB ; 6END ; 6O5H ; 4MS6 ; 3CHS ; 3B7T ; 3CHR ; 3FUJ ; 3FUH ; 6ENC ; 3FUK ; 5AEN ; 3FU0 ; 3FH8 ; 3FUL ; 5BPP ; 3FHE ; 2VJ8 ; 3FTV ; 5NID ; 3FUM ; 4RSY ; 3FUD ; 5NI4 ; 5N3W ; 3FH5 ; 1SQM ; 3FUE ; 3FTS ; 3FU3 ; 2R59 ; 4RVB ; 3U9W ; 5FWQ ; 3B7U ; 1HS6 ; 3FTW ; 4MKT ; 3CHQ ; 3FH7 ; 3FU5 ; 3FUF ; 5NIE ; 3FUI ; 3B7R ; 3FTX ; 5NI2 ; 4L2L ; 3CHP ; 3FTZ ; 4DPR ; 5NI6 ; 3FU6 ; 1H19 ; 3FTU ; 3FUN ; 3FTY ; 3B7S
Drugbank	DB11781 ; DB07104 ; DB02352 ; DB07292 ; DB07237 ; DB06917 ; DB07260 ; DB01197 ; DB07094 ; DB07099 ; DB07259 ; DB08040 ; DB06828 ; DB06851 ; DB08466 ; DB07102 ; DB05177 ; DB02062 ; DB03424 ; DB03366 ; DB07196 ; DB07258
KEGG	hsa:4048

Type

Detail

Target ID

T01Z6D

Protein Name

Leukotriene A-4 hydrolase

Uniprot ID

P09960

Protein Name Alias

LTA-4 hydrolase; EC 3.3.2.6; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H; EC 3.4.11.4

Gene ID

4048

Gene Symbol

LTA4H

Gene Alias

LTA4

TTD

T03691: Successful target

Pfam

PF01433 ; PF09127

0005634:nucleus

0070062:extracellular exosome

0006691:leukotriene metabolic process

0070006:metalloaminopeptidase activity

0043171:peptide catabolic process

0044267:cellular protein metabolic process

0004177:aminopeptidase activity

0004463:leukotriene-A4 hydrolase activity

0005829:cytosol

1904724:tertiary granule lumen

0045148:tripeptide aminopeptidase activity

0042759:long-chain fatty acid biosynthetic process

0043312:neutrophil degranulation

0003723:RNA binding

0005576:extracellular region

0008233:peptidase activity

0008270:zinc ion binding

0005654:nucleoplasm

1904813:ficolin-1-rich granule lumen

0004301:epoxide hydrolase activity

0019370:leukotriene biosynthetic process

PDB

3CHO ; 5NIA ; 4R7L ; 1GW6 ; 6ENB ; 6END ; 6O5H ; 4MS6 ; 3CHS ; 3B7T ; 3CHR ; 3FUJ ; 3FUH ; 6ENC ; 3FUK ; 5AEN ; 3FU0 ; 3FH8 ; 3FUL ; 5BPP ; 3FHE ; 2VJ8 ; 3FTV ; 5NID ; 3FUM ; 4RSY ; 3FUD ; 5NI4 ; 5N3W ; 3FH5 ; 1SQM ; 3FUE ; 3FTS ; 3FU3 ; 2R59 ; 4RVB ; 3U9W ; 5FWQ ; 3B7U ; 1HS6 ; 3FTW ; 4MKT ; 3CHQ ; 3FH7 ; 3FU5 ; 3FUF ; 5NIE ; 3FUI ; 3B7R ; 3FTX ; 5NI2 ; 4L2L ; 3CHP ; 3FTZ ; 4DPR ; 5NI6 ; 3FU6 ; 1H19 ; 3FTU ; 3FUN ; 3FTY ; 3B7S

Drugbank

DB11781 ; DB07104 ; DB02352 ; DB07292 ; DB07237 ; DB06917 ; DB07260 ; DB01197 ; DB07094 ; DB07099 ; DB07259 ; DB08040 ; DB06828 ; DB06851 ; DB08466 ; DB07102 ; DB05177 ; DB02062 ; DB03424 ; DB03366 ; DB07196 ; DB07258

KEGG

hsa:4048

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0416	Shan Shen	山参	NA	Panax ginseng
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 26)