HIT-result

Type	Detail
Target ID	T01N30
Protein Name	F-box/WD repeat-containing protein 7
Uniprot ID	Q969H0
Protein Name Alias	Archipelago homolog; hAgo; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; SEL-10; hCdc4
Gene ID	55294
Gene Symbol	FBXW7
Gene Alias	FBW7; FBX30; SEL10
TTD	T21705: Research target
Pfam	PF00400 ; PF12937
GO	0016567:protein ubiquitination 0042802:identical protein binding 0005634:nucleus 0001944:vasculature development 0055088:lipid homeostasis 2000346:negative regulation of hepatocyte proliferation 1903378:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 0005829:cytosol 0019005:SCF ubiquitin ligase complex 0051443:positive regulation of ubiquitin-protein transferase activity 0042752:regulation of circadian rhythm 0031625:ubiquitin protein ligase binding 2001205:negative regulation of osteoclast development 1901800:positive regulation of proteasomal protein catabolic process 0034644:cellular response to UV 0030674:protein-macromolecule adaptor activity 2000639:negative regulation of SREBP signaling pathway 0030324:lung development 0043687:post-translational protein modification 0097027:ubiquitin-protein transferase activator activity 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 1902806:regulation of cell cycle G1/S phase transition 1903146:regulation of autophagy of mitochondrion 2000060:positive regulation of ubiquitin-dependent protein catabolic process 0031648:protein destabilization 0030332:cyclin binding 0005783:endoplasmic reticulum 0001570:vasculogenesis 0048471:perinuclear region of cytoplasm 0031398:positive regulation of protein ubiquitination 0032880:regulation of protein localization 0005730:nucleolus 0010629:negative regulation of gene expression 0050821:protein stabilization 0010992:ubiquitin recycling 0070374:positive regulation of ERK1 and ERK2 cascade 0048511:rhythmic process 0007062:sister chromatid cohesion 1903955:positive regulation of protein targeting to mitochondrion 0000209:protein polyubiquitination 0032991:protein-containing complex 1990452:Parkin-FBXW7-Cul1 ubiquitin ligase complex 0045741:positive regulation of epidermal growth factor-activated receptor activity 0005794:Golgi apparatus 0007219:Notch signaling pathway 0031146:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 0005739:mitochondrion 0005737:cytoplasm 1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding 0016032:viral process 0010883:regulation of lipid storage 0010868:negative regulation of triglyceride biosynthetic process 0005654:nucleoplasm 0045746:negative regulation of Notch signaling pathway 0050816:phosphothreonine residue binding 0090049:regulation of cell migration involved in sprouting angiogenesis 0043130:ubiquitin binding 0006974:cellular response to DNA damage stimulus
PDB	2OVQ ; 2OVR ; 2OVP ; 5V4B ; 5IBK
Drugbank	NA
KEGG	hsa:55294

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Name: Oridonin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia