HIT-result

Type	Detail
Target ID	T03IB6
Protein Name	Transcription factor 7-like 2
Uniprot ID	Q9NQB0
Protein Name Alias	HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4
Gene ID	6934
Gene Symbol	TCF7L2
Gene Alias	TCF4
TTD	T54646: Research target
Pfam	PF08347 ; PF00505
GO	0008134:transcription factor binding 0060260:regulation of transcription initiation from RNA polymerase II promoter 0005634:nucleus 0045295:gamma-catenin binding 0007050:cell cycle arrest 0043565:sequence-specific DNA binding 1990907:beta-catenin-TCF complex 0032024:positive regulation of insulin secretion 0046827:positive regulation of protein export from nucleus 0007223:Wnt signaling pathway, calcium modulating pathway 0001103:RNA polymerase II repressing transcription factor binding 0048625:myoblast fate commitment 0051897:positive regulation of protein kinase B signaling 0048660:regulation of smooth muscle cell proliferation 0070369:beta-catenin-TCF7L2 complex 0071664:catenin-TCF7L2 complex 0010909:positive regulation of heparan sulfate proteoglycan biosynthetic process 0045892:negative regulation of transcription, DNA-templated 0009749:response to glucose 0016605:PML body 0045444:fat cell differentiation 1904837:beta-catenin-TCF complex assembly 0050679:positive regulation of epithelial cell proliferation 2001237:negative regulation of extrinsic apoptotic signaling pathway 0019901:protein kinase binding 0031016:pancreas development 0060070:canonical Wnt signaling pathway 0032350:regulation of hormone metabolic process 0032092:positive regulation of protein binding 0000785:chromatin 0000976:transcription regulatory region sequence-specific DNA binding 0035257:nuclear hormone receptor binding 0044334:canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0043570:maintenance of DNA repeat elements 0043433:negative regulation of DNA-binding transcription factor activity 0000122:negative regulation of transcription by RNA polymerase II 0003700:DNA-binding transcription factor activity 0070016:armadillo repeat domain binding 0006357:regulation of transcription by RNA polymerase II 0042593:glucose homeostasis 0090090:negative regulation of canonical Wnt signaling pathway 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0005654:nucleoplasm 2000675:negative regulation of type B pancreatic cell apoptotic process 0001568:blood vessel development 0045944:positive regulation of transcription by RNA polymerase II 0032993:protein-DNA complex 0008013:beta-catenin binding
PDB	1JPW ; 2GL7 ; 1JDH
Drugbank	NA
KEGG	hsa:6934

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Name: Geniposide

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H0972	Di Huang	地黄	Rehmanniae	Rehmannia glutinosa