HIT-result

Type	Detail
Target ID	T03ON1
Protein Name	Neurofibromin
Uniprot ID	P21359
Protein Name Alias	Neurofibromatosis-related protein NF-1
Gene ID	4763
Gene Symbol	NF1
Gene Alias	NA
TTD	NA
Pfam	PF13716 ; PF00616
GO	0007406:negative regulation of neuroblast proliferation 0007422:peripheral nervous system development 0043535:regulation of blood vessel endothelial cell migration 0000165:MAPK cascade 0045765:regulation of angiogenesis 0030424:axon 0001952:regulation of cell-matrix adhesion 0048147:negative regulation of fibroblast proliferation 0045762:positive regulation of adenylate cyclase activity 0030425:dendrite 0005730:nucleolus 0001666:response to hypoxia 0016020:membrane 0045124:regulation of bone resorption 0030199:collagen fibril organization 0007507:heart development 0050890:cognition 0007420:brain development 0007265:Ras protein signal transduction 0031210:phosphatidylcholine binding 0008429:phosphatidylethanolamine binding 0030336:negative regulation of cell migration 0043547:positive regulation of GTPase activity 0030036:actin cytoskeleton organization 0005096:GTPase activator activity 0005829:cytosol 0043409:negative regulation of MAPK cascade 0021897:forebrain astrocyte development 0043065:positive regulation of apoptotic process 0045685:regulation of glial cell differentiation 0043473:pigmentation 0006469:negative regulation of protein kinase activity 0021510:spinal cord development 0043407:negative regulation of MAP kinase activity 0001937:negative regulation of endothelial cell proliferation 0005737:cytoplasm 0001649:osteoblast differentiation 0048485:sympathetic nervous system development 0043525:positive regulation of neuron apoptotic process 0014044:Schwann cell development 0007154:cell communication 0021987:cerebral cortex development 0001656:metanephros development 0022011:myelination in peripheral nervous system 0014065:phosphatidylinositol 3-kinase signaling 0005634:nucleus 0001889:liver development 0048593:camera-type eye morphogenesis 0048844:artery morphogenesis 0048715:negative regulation of oligodendrocyte differentiation 0042060:wound healing 0030198:extracellular matrix organization 0030325:adrenal gland development 0043087:regulation of GTPase activity 0048853:forebrain morphogenesis 0008542:visual learning 0048745:smooth muscle tissue development
PDB	3PEG ; 1NF1 ; 6OB3 ; 6V65 ; 3PG7 ; 3P7Z ; 6OB2 ; 2D4Q ; 2E2X ; 6V6F
Drugbank	NA
KEGG	hsa:4763

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