HIT-result

Target Description

Type	Detail
Target ID	T10OIU
Protein Name	Erythropoietin
Uniprot ID	P01588
Protein Name Alias	Epoetin
Gene ID	2056
Gene Symbol	EPO
Gene Alias	NA
TTD	T07958: Clinical Trial target
Pfam	PF00758
GO	0007568:aging 0044297:cell body 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0038162:erythropoietin-mediated signaling pathway 0033574:response to testosterone 0043249:erythrocyte maturation 0043627:response to estrogen 0010976:positive regulation of neuron projection development 0030218:erythrocyte differentiation 0042104:positive regulation of activated T cell proliferation 0006953:acute-phase response 0033189:response to vitamin A 0009986:cell surface 0008284:positive regulation of cell population proliferation 0006915:apoptotic process 1901215:negative regulation of neuron death 0005128:erythropoietin receptor binding 0030295:protein kinase activator activity 0018105:peptidyl-serine phosphorylation 2001258:negative regulation of cation channel activity 0008015:blood circulation 0051602:response to electrical stimulus 0070555:response to interleukin-1 0005615:extracellular space 0042541:hemoglobin biosynthetic process 0010523:negative regulation of calcium ion transport into cytosol 0046579:positive regulation of Ras protein signal transduction 0005125:cytokine activity 0005179:hormone activity 0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia 0070374:positive regulation of ERK1 and ERK2 cascade 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0009651:response to salt stress 0045666:positive regulation of neuron differentiation 0045893:positive regulation of transcription, DNA-templated 0005576:extracellular region 0071474:cellular hyperosmotic response 0000122:negative regulation of transcription by RNA polymerase II 0007165:signal transduction 0007566:embryo implantation 0032496:response to lipopolysaccharide 1902251:negative regulation of erythrocyte apoptotic process 0055093:response to hyperoxia 0071548:response to dexamethasone 1902219:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 0048678:response to axon injury
PDB	1CN4 ; 1EER ; 1BUY
Drugbank	NA
KEGG	hsa:2056

Type

Detail

Target ID

T10OIU

Protein Name

Erythropoietin

Uniprot ID

P01588

Protein Name Alias

Epoetin

Gene ID

2056

Gene Symbol

EPO

Gene Alias

TTD

T07958: Clinical Trial target

Pfam

PF00758

0007568:aging

0044297:cell body

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0038162:erythropoietin-mediated signaling pathway

0033574:response to testosterone

0043249:erythrocyte maturation

0043627:response to estrogen

0010976:positive regulation of neuron projection development

0030218:erythrocyte differentiation

0042104:positive regulation of activated T cell proliferation

0006953:acute-phase response

0033189:response to vitamin A

0009986:cell surface

0008284:positive regulation of cell population proliferation

0006915:apoptotic process

1901215:negative regulation of neuron death

0005128:erythropoietin receptor binding

0030295:protein kinase activator activity

0018105:peptidyl-serine phosphorylation

2001258:negative regulation of cation channel activity

0008015:blood circulation

0051602:response to electrical stimulus

0070555:response to interleukin-1

0005615:extracellular space

0042541:hemoglobin biosynthetic process

0010523:negative regulation of calcium ion transport into cytosol

0046579:positive regulation of Ras protein signal transduction

0005125:cytokine activity

0005179:hormone activity

0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia

0070374:positive regulation of ERK1 and ERK2 cascade

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0009651:response to salt stress

0045666:positive regulation of neuron differentiation

0045893:positive regulation of transcription, DNA-templated

0005576:extracellular region

0071474:cellular hyperosmotic response

0000122:negative regulation of transcription by RNA polymerase II

0007165:signal transduction

0007566:embryo implantation

0032496:response to lipopolysaccharide

1902251:negative regulation of erythrocyte apoptotic process

0055093:response to hyperoxia

0071548:response to dexamethasone

1902219:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

0048678:response to axon injury

PDB

1CN4 ; 1EER ; 1BUY

Drugbank

KEGG

hsa:2056

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0970	Di Gu Pi	地骨皮	root - bark of chinese wolfberry	Cortex lycii radicis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0416	Shan Shen	山参	NA	Panax ginseng
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 13)