HIT-result

Target Description

Type	Detail
Target ID	T10WAM
Protein Name	Death-associated protein kinase 1
Uniprot ID	P53355
Protein Name Alias	DAP kinase 1; EC 2.7.11.1
Gene ID	1612
Gene Symbol	DAPK1
Gene Alias	DAPK
TTD	NA
Pfam	PF00069 ; PF12796 ; PF00531
GO	0042802:identical protein binding 0005634:nucleus 0046777:protein autophosphorylation 0035556:intracellular signal transduction 0042981:regulation of apoptotic process 0004672:protein kinase activity 0106310:protein serine kinase activity 0017148:negative regulation of translation 0004674:protein serine/threonine kinase activity 0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0106311:protein threonine kinase activity 0004683:calmodulin-dependent protein kinase activity 0006915:apoptotic process 2000310:regulation of NMDA receptor activity 0005737:cytoplasm 0071346:cellular response to interferon-gamma 0005524:ATP binding 0005886:plasma membrane 0097190:apoptotic signaling pathway 0017075:syntaxin-1 binding 0005516:calmodulin binding 0010508:positive regulation of autophagy 0043065:positive regulation of apoptotic process 0006468:protein phosphorylation 0015629:actin cytoskeleton 0071447:cellular response to hydroperoxide 0002357:defense response to tumor cell 0005525:GTP binding 0010506:regulation of autophagy
PDB	3GU4 ; 1YR5 ; 1WVY ; 5AV0 ; 3GUB ; 4YPD ; 1P4F ; 3F5G ; 1JKS ; 1JKL ; 2XZS ; 3EH9 ; 6QN4 ; 6IN4 ; 1IG1 ; 4UV0 ; 2Y0A ; 5AUX ; 5AUY ; 5AV2 ; 5AV1 ; 3GU6 ; 3DFC ; 4YO4 ; 5AV3 ; 1WVW ; 3ZXT ; 4TXC ; 2W4J ; 6QMO ; 1JKT ; 2X0G ; 2YAK ; 5AUU ; 6FHA ; 6FHB ; 2XUU ; 3GU8 ; 3GU7 ; 3GU5 ; 4PF4 ; 3F5U ; 1WVX ; 3EHA ; 3DGK ; 4B4L ; 2Y4V ; 2W4K ; 4TL0 ; 5AUZ ; 5AUW ; 6GY5 ; 5AUT ; 5AV4 ; 6AAR ; 1JKK ; 2Y4P ; 5AUV
Drugbank	DB04395 ; DB04069 ; DB12010 ; DB07444
KEGG	hsa:1612

Type

Detail

Target ID

T10WAM

Protein Name

Death-associated protein kinase 1

Uniprot ID

P53355

Protein Name Alias

DAP kinase 1; EC 2.7.11.1

Gene ID

1612

Gene Symbol

DAPK1

Gene Alias

DAPK

TTD

Pfam

PF00069 ; PF12796 ; PF00531

0042802:identical protein binding

0005634:nucleus

0046777:protein autophosphorylation

0035556:intracellular signal transduction

0042981:regulation of apoptotic process

0004672:protein kinase activity

0106310:protein serine kinase activity

0017148:negative regulation of translation

0004674:protein serine/threonine kinase activity

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0106311:protein threonine kinase activity

0004683:calmodulin-dependent protein kinase activity

0006915:apoptotic process

2000310:regulation of NMDA receptor activity

0005737:cytoplasm

0071346:cellular response to interferon-gamma

0005524:ATP binding

0005886:plasma membrane

0097190:apoptotic signaling pathway

0017075:syntaxin-1 binding

0005516:calmodulin binding

0010508:positive regulation of autophagy

0043065:positive regulation of apoptotic process

0006468:protein phosphorylation

0015629:actin cytoskeleton

0071447:cellular response to hydroperoxide

0002357:defense response to tumor cell

0005525:GTP binding

0010506:regulation of autophagy

PDB

3GU4 ; 1YR5 ; 1WVY ; 5AV0 ; 3GUB ; 4YPD ; 1P4F ; 3F5G ; 1JKS ; 1JKL ; 2XZS ; 3EH9 ; 6QN4 ; 6IN4 ; 1IG1 ; 4UV0 ; 2Y0A ; 5AUX ; 5AUY ; 5AV2 ; 5AV1 ; 3GU6 ; 3DFC ; 4YO4 ; 5AV3 ; 1WVW ; 3ZXT ; 4TXC ; 2W4J ; 6QMO ; 1JKT ; 2X0G ; 2YAK ; 5AUU ; 6FHA ; 6FHB ; 2XUU ; 3GU8 ; 3GU7 ; 3GU5 ; 4PF4 ; 3F5U ; 1WVX ; 3EHA ; 3DGK ; 4B4L ; 2Y4V ; 2W4K ; 4TL0 ; 5AUZ ; 5AUW ; 6GY5 ; 5AUT ; 5AV4 ; 6AAR ; 1JKK ; 2Y4P ; 5AUV

Drugbank

DB04395 ; DB04069 ; DB12010 ; DB07444

KEGG

hsa:1612

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H0393	Sang Shen	桑葚	Mulberry	Morus alba
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0395	Sang Shen Qing Gao	桑葚清膏	Mulberry	Morus alba
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0532	Teng Huang	藤黄	Gamboge tree resin	Garcinia morella
H0389	Sang Bai Pi Liu Jin Gao	桑白皮流浸膏	Prepared root-bark white mulberry	Cortex mori radicis praeparata
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H1190	Hong Lian	洪连	all-grass of shorttube lagotis	Herba lagotidis
H0812	Sang Bai Pi	桑白皮	Prepared root-bark white mulberry	Cortex mori radicis praeparata
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0879	Chuan Po Shi	穿破石	root of tricuspid cudrania	Radix cudraniae
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0394	Sang Shen Jin Gao	桑葚浸膏	Mulberry	Morus alba

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 21)