HIT-result

Type	Detail
Target ID	T11B42
Protein Name	MAP kinase-activated protein kinase 2
Uniprot ID	P49137
Protein Name Alias	MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2; EC 2.7.11.1
Gene ID	9261
Gene Symbol	MAPKAPK2
Gene Alias	NA
TTD	T21307: Clinical Trial target
Pfam	PF00069
GO	0051019:mitogen-activated protein kinase binding 0005634:nucleus 0043488:regulation of mRNA stability 0046777:protein autophosphorylation 0070062:extracellular exosome 0035556:intracellular signal transduction 0006691:leukotriene metabolic process 0004672:protein kinase activity 0106310:protein serine kinase activity 0005829:cytosol 0004674:protein serine/threonine kinase activity 1900034:regulation of cellular response to heat 0106311:protein threonine kinase activity 0004683:calmodulin-dependent protein kinase activity 0035924:cellular response to vascular endothelial growth factor stimulus 0005813:centrosome 0044351:macropinocytosis 0048010:vascular endothelial growth factor receptor signaling pathway 0038066:p38MAPK cascade 0000187:activation of MAPK activity 0018105:peptidyl-serine phosphorylation 0032675:regulation of interleukin-6 production 0005737:cytoplasm 0002224:toll-like receptor signaling pathway 0000165:MAPK cascade 0005524:ATP binding 0032680:regulation of tumor necrosis factor production 0005516:calmodulin binding 0006954:inflammatory response 0006468:protein phosphorylation 0032760:positive regulation of tumor necrosis factor production 0070935:3'-UTR-mediated mRNA stabilization 0048839:inner ear development 0005654:nucleoplasm 0032496:response to lipopolysaccharide 0009931:calcium-dependent protein serine/threonine kinase activity 0034097:response to cytokine 0006974:cellular response to DNA damage stimulus
PDB	3R2Y ; 2OZA ; 3FYK ; 3GOK ; 3FPM ; 3R30 ; 3WI6 ; 3M42 ; 2P3G ; 3M2W ; 2OKR ; 3R2B ; 3FYJ ; 2JBP ; 4TYH ; 2ONL ; 3KA0 ; 2JBO ; 2PZY ; 3KC3 ; 1KWP ; 1NXK ; 3KGA ; 6TCA ; 3A2C ; 1NY3
Drugbank	DB07430 ; DB07728 ; DB07234 ; DB07431 ; DB08358 ; DB02010 ; DB07406
KEGG	hsa:9261

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Name: Angiotensin Ii

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens