Target Description

Type Detail
Target ID T11B42
Protein Name MAP kinase-activated protein kinase 2
Uniprot ID P49137
Protein Name Alias MAPK-activated protein kinase 2;  MAPKAP kinase 2;  MAPKAP-K2;  MAPKAPK-2;  MK-2;  MK2;  EC
Gene ID 9261
Gene Symbol MAPKAPK2
Gene Alias NA
TTD T21307: Clinical Trial target
Pfam PF00069
0051019:mitogen-activated protein kinase binding


0043488:regulation of mRNA stability

0046777:protein autophosphorylation

0070062:extracellular exosome

0035556:intracellular signal transduction

0006691:leukotriene metabolic process

0004672:protein kinase activity

0106310:protein serine kinase activity


0004674:protein serine/threonine kinase activity

1900034:regulation of cellular response to heat

0106311:protein threonine kinase activity

0004683:calmodulin-dependent protein kinase activity

0035924:cellular response to vascular endothelial growth factor stimulus



0048010:vascular endothelial growth factor receptor signaling pathway

0038066:p38MAPK cascade

0000187:activation of MAPK activity

0018105:peptidyl-serine phosphorylation

0032675:regulation of interleukin-6 production


0002224:toll-like receptor signaling pathway

0000165:MAPK cascade

0005524:ATP binding

0032680:regulation of tumor necrosis factor production

0005516:calmodulin binding

0006954:inflammatory response

0006468:protein phosphorylation

0032760:positive regulation of tumor necrosis factor production

0070935:3'-UTR-mediated mRNA stabilization

0048839:inner ear development


0032496:response to lipopolysaccharide

0009931:calcium-dependent protein serine/threonine kinase activity

0034097:response to cytokine

0006974:cellular response to DNA damage stimulus

PDB 3R2Y ; 2OZA ; 3FYK ; 3GOK ; 3FPM ; 3R30 ; 3WI6 ; 3M42 ; 2P3G ; 3M2W ; 2OKR ; 3R2B ; 3FYJ ; 2JBP ; 4TYH ; 2ONL ; 3KA0 ; 2JBO ; 2PZY ; 3KC3 ; 1KWP ; 1NXK ; 3KGA ; 6TCA ; 3A2C ; 1NY3
Drugbank DB07430 ; DB07728 ; DB07234 ; DB07431 ; DB08358 ; DB02010 ; DB07406
KEGG hsa:9261

Related Compounds  (Total: 1)

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Name: Angiotensin Ii

Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens