HIT-result

Type	Detail
Target ID	T16P5N
Protein Name	Extracellular calcium-sensing receptor
Uniprot ID	P41180
Protein Name Alias	CaR; CaSR; hCasR; Parathyroid cell calcium-sensing receptor 1; PCaR1
Gene ID	846
Gene Symbol	CASR
Gene Alias	GPRC2A; PCAR1
TTD	T92076: Successful target
Pfam	PF00003 ; PF01094 ; PF07562
GO	0071404:cellular response to low-density lipoprotein particle stimulus 0005513:detection of calcium ion 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0005634:nucleus 1901653:cellular response to peptide 0070509:calcium ion import 0007254:JNK cascade 0032781:positive regulation of ATPase activity 1902476:chloride transmembrane transport 0043679:axon terminus 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0004435:phosphatidylinositol phospholipase C activity 0051924:regulation of calcium ion transport 0042803:protein homodimerization activity 0010628:positive regulation of gene expression 0071774:response to fibroblast growth factor 0042311:vasodilation 0007635:chemosensory behavior 0071456:cellular response to hypoxia 0044325:ion channel binding 0009986:cell surface 0035729:cellular response to hepatocyte growth factor stimulus 0002931:response to ischemia 0006874:cellular calcium ion homeostasis 0006915:apoptotic process 0071333:cellular response to glucose stimulus 0060613:fat pad development 0070374:positive regulation of ERK1 and ERK2 cascade 0004930:G protein-coupled receptor activity 0071305:cellular response to vitamin D 0009653:anatomical structure morphogenesis 0043025:neuronal cell body 0005178:integrin binding 0005886:plasma membrane 0016324:apical plasma membrane 0016597:amino acid binding 0045907:positive regulation of vasoconstriction 0007186:G protein-coupled receptor signaling pathway 0005887:integral component of plasma membrane 0019901:protein kinase binding 0032782:bile acid secretion 0090280:positive regulation of calcium ion import 0008284:positive regulation of cell population proliferation 0032024:positive regulation of insulin secretion 0005737:cytoplasm 0048754:branching morphogenesis of an epithelial tube 0001503:ossification 0050927:positive regulation of positive chemotaxis 0016323:basolateral plasma membrane 0005509:calcium ion binding
PDB	5FBH ; 5K5S ; 5K5T ; 5FBK
Drugbank	DB12865 ; DB01012 ; DB00127 ; DB11348 ; DB05695 ; DB11093 ; DB05255 ; DB00994 ; DB14481
KEGG	hsa:846

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Name: Spermine

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Name: Cholecalciferol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0194	Ma Bing Lang	马槟榔	Masaikai caper	Capparis masaikai
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens