HIT-result

Type	Detail
Target ID	T18ZHL
Protein Name	Platelet factor 4
Uniprot ID	P02776
Protein Name Alias	PF-4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A
Gene ID	5196
Gene Symbol	PF4
Gene Alias	CXCL4; SCYB4
TTD	T30827: Clinical Trial target
Pfam	PF00048
GO	2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 0030168:platelet activation 0070098:chemokine-mediated signaling pathway 0005615:extracellular space 0045236:CXCR chemokine receptor binding 0032760:positive regulation of tumor necrosis factor production 0007186:G protein-coupled receptor signaling pathway 0045651:positive regulation of macrophage differentiation 0048248:CXCR3 chemokine receptor binding 0002576:platelet degranulation 0005576:extracellular region 0030595:leukocyte chemotaxis 0031640:killing of cells of other organism 0008009:chemokine activity 0031093:platelet alpha granule lumen 0010744:positive regulation of macrophage derived foam cell differentiation 0016525:negative regulation of angiogenesis 0005737:cytoplasm 0045944:positive regulation of transcription by RNA polymerase II 0071222:cellular response to lipopolysaccharide 0019221:cytokine-mediated signaling pathway 0010628:positive regulation of gene expression 0006954:inflammatory response 0045347:negative regulation of MHC class II biosynthetic process 0042127:regulation of cell population proliferation 0062023:collagen-containing extracellular matrix 0020005:symbiont-containing vacuole membrane 0030593:neutrophil chemotaxis 0051873:killing by host of symbiont cells 0045652:regulation of megakaryocyte differentiation 0008201:heparin binding 0061844:antimicrobial humoral immune response mediated by antimicrobial peptide 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0042832:defense response to protozoan 0045653:negative regulation of megakaryocyte differentiation
PDB	1DN3 ; 1F9S ; 1F9R ; 1PFN ; 1PFM ; 1RHP ; 1F9Q ; 4RAU ; 4R9W ; 4R9Y
Drugbank	DB01109 ; DB00055
KEGG	hsa:5196

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Name: heparin

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