Target Description

Type Detail
Target ID T21TXM
Protein Name Adapter molecule crk
Uniprot ID P46108
Protein Name Alias Proto-oncogene c-Crk;  p38
Gene ID 1398
Gene Symbol CRK
Gene Alias NA
TTD T27297: Research target
Pfam PF07653 ; PF00018 ; PF00017
GO
0019900:kinase binding

1990314:cellular response to insulin-like growth factor stimulus

0019221:cytokine-mediated signaling pathway

0050773:regulation of dendrite development

0061847:response to cholecystokinin

0097110:scaffold protein binding

0090630:activation of GTPase activity

1900026:positive regulation of substrate adhesion-dependent cell spreading

0048010:vascular endothelial growth factor receptor signaling pathway

0061045:negative regulation of wound healing

0043393:regulation of protein binding

0030307:positive regulation of cell growth

0043087:regulation of GTPase activity

0035020:regulation of Rac protein signal transduction

0098749:cerebellar neuron development

0030010:establishment of cell polarity

0038026:reelin-mediated signaling pathway

0045121:membrane raft

0009966:regulation of signal transduction

0001878:response to yeast

1990090:cellular response to nerve growth factor stimulus

2000404:regulation of T cell migration

0006357:regulation of transcription by RNA polymerase II

1902531:regulation of intracellular signal transduction

1990859:cellular response to endothelin

0035728:response to hepatocyte growth factor

0045309:protein phosphorylated amino acid binding

0032956:regulation of actin cytoskeleton organization

0016020:membrane

0070062:extracellular exosome

0016358:dendrite development

0006629:lipid metabolic process

0000186:activation of MAPKK activity

0045953:negative regulation of natural killer cell mediated cytotoxicity

0005829:cytosol

0030036:actin cytoskeleton organization

0033628:regulation of cell adhesion mediated by integrin

1990782:protein tyrosine kinase binding

0043621:protein self-association

0014911:positive regulation of smooth muscle cell migration

0042542:response to hydrogen peroxide

0001784:phosphotyrosine residue binding

0032991:protein-containing complex

0005159:insulin-like growth factor receptor binding

0001764:neuron migration

0060326:cell chemotaxis

0005886:plasma membrane

0035685:helper T cell diapedesis

0031625:ubiquitin protein ligase binding

2000146:negative regulation of cell motility

0042169:SH2 domain binding

0005634:nucleus

0035591:signaling adaptor activity

0046875:ephrin receptor binding

0071732:cellular response to nitric oxide

0048013:ephrin receptor signaling pathway

0021987:cerebral cortex development

0021766:hippocampus development

0008360:regulation of cell shape

0015629:actin cytoskeleton

0005737:cytoplasm

0008092:cytoskeletal protein binding

0038096:Fc-gamma receptor signaling pathway involved in phagocytosis

0017124:SH3 domain binding

0071560:cellular response to transforming growth factor beta stimulus

0030159:signaling receptor complex adaptor activity

PDB 2MS4 ; 2EYW ; 1JU5 ; 2EYZ ; 2EYY ; 6ATV ; 2DVJ ; 2EYV ; 5UL6 ; 2EYX
Drugbank NA
KEGG hsa:1398

Related Compounds  (Total: 1)

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C1223
Name: Celecoxib


Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens