HIT-result

Type	Detail
Target ID	T21TXM
Protein Name	Adapter molecule crk
Uniprot ID	P46108
Protein Name Alias	Proto-oncogene c-Crk; p38
Gene ID	1398
Gene Symbol	CRK
Gene Alias	NA
TTD	T27297: Research target
Pfam	PF07653 ; PF00018 ; PF00017
GO	0019900:kinase binding 1990314:cellular response to insulin-like growth factor stimulus 0019221:cytokine-mediated signaling pathway 0050773:regulation of dendrite development 0061847:response to cholecystokinin 0097110:scaffold protein binding 0090630:activation of GTPase activity 1900026:positive regulation of substrate adhesion-dependent cell spreading 0048010:vascular endothelial growth factor receptor signaling pathway 0061045:negative regulation of wound healing 0043393:regulation of protein binding 0030307:positive regulation of cell growth 0043087:regulation of GTPase activity 0035020:regulation of Rac protein signal transduction 0098749:cerebellar neuron development 0030010:establishment of cell polarity 0038026:reelin-mediated signaling pathway 0045121:membrane raft 0009966:regulation of signal transduction 0001878:response to yeast 1990090:cellular response to nerve growth factor stimulus 2000404:regulation of T cell migration 0006357:regulation of transcription by RNA polymerase II 1902531:regulation of intracellular signal transduction 1990859:cellular response to endothelin 0035728:response to hepatocyte growth factor 0045309:protein phosphorylated amino acid binding 0032956:regulation of actin cytoskeleton organization 0016020:membrane 0070062:extracellular exosome 0016358:dendrite development 0006629:lipid metabolic process 0000186:activation of MAPKK activity 0045953:negative regulation of natural killer cell mediated cytotoxicity 0005829:cytosol 0030036:actin cytoskeleton organization 0033628:regulation of cell adhesion mediated by integrin 1990782:protein tyrosine kinase binding 0043621:protein self-association 0014911:positive regulation of smooth muscle cell migration 0042542:response to hydrogen peroxide 0001784:phosphotyrosine residue binding 0032991:protein-containing complex 0005159:insulin-like growth factor receptor binding 0001764:neuron migration 0060326:cell chemotaxis 0005886:plasma membrane 0035685:helper T cell diapedesis 0031625:ubiquitin protein ligase binding 2000146:negative regulation of cell motility 0042169:SH2 domain binding 0005634:nucleus 0035591:signaling adaptor activity 0046875:ephrin receptor binding 0071732:cellular response to nitric oxide 0048013:ephrin receptor signaling pathway 0021987:cerebral cortex development 0021766:hippocampus development 0008360:regulation of cell shape 0015629:actin cytoskeleton 0005737:cytoplasm 0008092:cytoskeletal protein binding 0038096:Fc-gamma receptor signaling pathway involved in phagocytosis 0017124:SH3 domain binding 0071560:cellular response to transforming growth factor beta stimulus 0030159:signaling receptor complex adaptor activity
PDB	2MS4 ; 2EYW ; 1JU5 ; 2EYZ ; 2EYY ; 6ATV ; 2DVJ ; 2EYV ; 5UL6 ; 2EYX
Drugbank	NA
KEGG	hsa:1398

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Name: Celecoxib

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens