HIT-result

Target Description

Type	Detail
Target ID	T24YNT
Protein Name	E3 ubiquitin-protein ligase RNF8
Uniprot ID	O76064
Protein Name Alias	hRNF8; EC 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8
Gene ID	9025
Gene Symbol	RNF8
Gene Alias	KIAA0646
TTD	NA
Pfam	PF00498
GO	0016567:protein ubiquitination 0042802:identical protein binding 0005634:nucleus 0004842:ubiquitin-protein transferase activity 0006302:double-strand break repair 0034244:negative regulation of transcription elongation from RNA polymerase II promoter 0005829:cytosol 0070936:protein K48-linked ubiquitination 0031625:ubiquitin protein ligase binding 0003682:chromatin binding 0051865:protein autoubiquitination 0000151:ubiquitin ligase complex 0010212:response to ionizing radiation 0007049:cell cycle 0000781:chromosome, telomeric region 0006511:ubiquitin-dependent protein catabolic process 0035093:spermatogenesis, exchange of chromosomal proteins 0033523:histone H2B ubiquitination 0030496:midbody 0045190:isotype switching 0036297:interstrand cross-link repair 0070534:protein K63-linked ubiquitination 0006303:double-strand break repair via nonhomologous end joining 0007286:spermatid development 0070535:histone H2A K63-linked ubiquitination 0008270:zinc ion binding 0042803:protein homodimerization activity 0042393:histone binding 0016032:viral process 0051301:cell division 0005654:nucleoplasm 0035861:site of double-strand break 0045739:positive regulation of DNA repair 0061630:ubiquitin protein ligase activity 0043486:histone exchange 0033522:histone H2A ubiquitination 0043130:ubiquitin binding 0006974:cellular response to DNA damage stimulus
PDB	4AYC ; 4ORH ; 2PIE ; 2CSW ; 4WHV
Drugbank	NA
KEGG	hsa:9025

Type

Detail

Target ID

T24YNT

Protein Name

E3 ubiquitin-protein ligase RNF8

Uniprot ID

O76064

Protein Name Alias

hRNF8; EC 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Gene ID

9025

Gene Symbol

RNF8

Gene Alias

KIAA0646

TTD

Pfam

PF00498

0016567:protein ubiquitination

0042802:identical protein binding

0005634:nucleus

0004842:ubiquitin-protein transferase activity

0006302:double-strand break repair

0034244:negative regulation of transcription elongation from RNA polymerase II promoter

0005829:cytosol

0070936:protein K48-linked ubiquitination

0031625:ubiquitin protein ligase binding

0003682:chromatin binding

0051865:protein autoubiquitination

0000151:ubiquitin ligase complex

0010212:response to ionizing radiation

0007049:cell cycle

0000781:chromosome, telomeric region

0006511:ubiquitin-dependent protein catabolic process

0035093:spermatogenesis, exchange of chromosomal proteins

0033523:histone H2B ubiquitination

0030496:midbody

0045190:isotype switching

0036297:interstrand cross-link repair

0070534:protein K63-linked ubiquitination

0006303:double-strand break repair via nonhomologous end joining

0007286:spermatid development

0070535:histone H2A K63-linked ubiquitination

0008270:zinc ion binding

0042803:protein homodimerization activity

0042393:histone binding

0016032:viral process

0051301:cell division

0005654:nucleoplasm

0035861:site of double-strand break

0045739:positive regulation of DNA repair

0061630:ubiquitin protein ligase activity

0043486:histone exchange

0033522:histone H2A ubiquitination

0043130:ubiquitin binding

0006974:cellular response to DNA damage stimulus

PDB

4AYC ; 4ORH ; 2PIE ; 2CSW ; 4WHV

Drugbank

KEGG

hsa:9025

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0345	Qing Guo Tan	青果炭	white olive	Canarium album
H0975	Di Mian Cao	地绵草	NA	Euphorbia humifusa
H0547	Cang Qing Guo	藏青果	Myrobalan	Terminalia chebula
H1137	Gui Yuan	桂圆	NA	Dimocarpus longan
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0974	Di Jin Cao	地锦草	Humifuse euphorbia	Euphorbia humifusa
H0128	Lao Guan Cao	老鹳草	Wilford cranesbill	Geranium wilfordii
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0340	Bi Ma Zi	蓖麻子	Castorbean seed	Ricinus communis
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H1170	He Zi	诃子	Medicine terminalia	Terminalia chebula
H0344	Qing Guo	青果	Olive	Canarium album
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0060	Jin Si Ku Lian	金丝苦楝	NA	Cardiospermum halicacabum
H1171	He Zi Rou	诃子肉	Medicine terminalia	Terminalia chebula
H1082	Gan Lan	橄榄	Cabbage	Canarium album
H0569	Tu Er San	兔儿伞	Syneilesis*	Syneilesis palmata

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 17)