HIT-result

Type	Detail
Target ID	T26FBV
Protein Name	Protein-glutamine gamma-glutamyltransferase 2
Uniprot ID	P21980
Protein Name Alias	EC 2.3.2.13; Erythrocyte transglutaminase; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; EC 3.4.-.-; Protein G alpha(h); G(h); Protein-glutamine deamidase TGM2; EC 3.5.1.44; Protein-glutamine dopaminyltransferase TGM2; EC 2.3.1.-; Protein-glutamine histaminyltransferase TGM2; EC 2.3.1.-; Protein-glutamine noradrenalinyltransferase TGM2; EC 2.3.1.-; Protein-glutamine serotonyltransferase TGM2; EC 2.3.1.-; Tissue transglutaminase; tTG; tTgase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase II; TGase II; Transglutaminase-2; TG2; TGase-2; hTG2
Gene ID	7052
Gene Symbol	TGM2
Gene Alias	NA
TTD	T05387: Preclinical target
Pfam	PF01841 ; PF00868 ; PF00927
GO	0070062:extracellular exosome 0019904:protein domain specific binding 0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0018149:peptide cross-linking 0003810:protein-glutamine gamma-glutamyltransferase activity 0001974:blood vessel remodeling 0045785:positive regulation of cell adhesion 0005925:focal adhesion 0046872:metal ion binding 0060445:branching involved in salivary gland morphogenesis 0005829:cytosol 0043065:positive regulation of apoptotic process 0042802:identical protein binding 0005886:plasma membrane 0051561:positive regulation of mitochondrial calcium ion concentration 0018153:isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine 0043277:apoptotic cell clearance 0060662:salivary gland cavitation 0048661:positive regulation of smooth muscle cell proliferation 0005783:endoplasmic reticulum 0005739:mitochondrion 0050729:positive regulation of inflammatory response 0031226:intrinsic component of plasma membrane 0032471:negative regulation of endoplasmic reticulum calcium ion concentration 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0005525:GTP binding 0062023:collagen-containing extracellular matrix
PDB	2Q3Z ; 3S3P ; 4PYG ; 3S3J ; 6A8P ; 6KZB ; 1KV3 ; 3S3S ; 1FAU ; 3LY6
Drugbank	DB11254 ; DB04315 ; DB00130
KEGG	hsa:7052

Go to browser

Name: rottlerin

Go to browser

Name: Cysteamine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens