HIT-result

Type	Detail
Target ID	T26FJI
Protein Name	ATP-binding cassette sub-family A member 2
Uniprot ID	Q9BZC7
Protein Name Alias	EC 7.6.2.-; ATP-binding cassette transporter 2; ATP-binding cassette 2
Gene ID	20
Gene Symbol	ABCA2
Gene Alias	ABC2; KIAA1062
TTD	NA
Pfam	PF00005
GO	0016887:ATPase activity 0005768:endosome 0006629:lipid metabolic process 0071072:negative regulation of phospholipid biosynthetic process 0010872:regulation of cholesterol esterification 0005319:lipid transporter activity 0055085:transmembrane transport 0099040:ceramide translocation 0090370:negative regulation of cholesterol efflux 1902993:positive regulation of amyloid precursor protein catabolic process 0005765:lysosomal membrane 1902004:positive regulation of amyloid-beta formation 1904375:regulation of protein localization to cell periphery 0007626:locomotory behavior 0060049:regulation of protein glycosylation 0070723:response to cholesterol 0016020:membrane 0032289:central nervous system myelin formation 1905601:negative regulation of receptor-mediated endocytosis involved in cholesterol transport 0043231:intracellular membrane-bounded organelle 0061135:endopeptidase regulator activity 0000166:nucleotide binding 0090156:cellular sphingolipid homeostasis 0090155:negative regulation of sphingolipid biosynthetic process 0048545:response to steroid hormone 0032383:regulation of intracellular cholesterol transport 0042626:ATPase-coupled transmembrane transporter activity 0005524:ATP binding 0016021:integral component of membrane 0005764:lysosome 0006357:regulation of transcription by RNA polymerase II 0031410:cytoplasmic vesicle 0005815:microtubule organizing center 0010008:endosome membrane 0042632:cholesterol homeostasis 0032805:positive regulation of low-density lipoprotein particle receptor catabolic process 1905598:negative regulation of low-density lipoprotein receptor activity 2000008:regulation of protein localization to cell surface 0150104:transport across blood-brain barrier 0150110:negative regulation of cholesterol esterification 0006869:lipid transport 0006684:sphingomyelin metabolic process 0032384:negative regulation of intracellular cholesterol transport 0001573:ganglioside metabolic process 0005886:plasma membrane 0042986:positive regulation of amyloid precursor protein biosynthetic process 0043190:ATP-binding cassette (ABC) transporter complex 0042493:response to drug 1901873:regulation of post-translational protein modification 0046512:sphingosine biosynthetic process 0006687:glycosphingolipid metabolic process 0099038:ceramide floppase activity
PDB	NA
Drugbank	NA
KEGG	hsa:20

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Name: vinblastine

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