HIT-result

Type	Detail
Target ID	T32YN4
Protein Name	GTPase HRas
Uniprot ID	P01112
Protein Name Alias	EC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras
Gene ID	3265
Gene Symbol	HRAS
Gene Alias	HRAS1
TTD	T71081: Research target
Pfam	PF00071
GO	0090398:cellular senescence 1900029:positive regulation of ruffle assembly 0043406:positive regulation of MAP kinase activity 0048013:ephrin receptor signaling pathway 0005829:cytosol 0001934:positive regulation of protein phosphorylation 0050852:T cell receptor signaling pathway 0008022:protein C-terminus binding 0090303:positive regulation of wound healing 0009887:animal organ morphogenesis 0034260:negative regulation of GTPase activity 0050679:positive regulation of epithelial cell proliferation 0098978:glutamatergic synapse 0043524:negative regulation of neuron apoptotic process 0048169:regulation of long-term neuronal synaptic plasticity 0097193:intrinsic apoptotic signaling pathway 0005654:nucleoplasm 0010629:negative regulation of gene expression 0019003:GDP binding 0002223:stimulatory C-type lectin receptor signaling pathway 0045944:positive regulation of transcription by RNA polymerase II 0046330:positive regulation of JNK cascade 0005789:endoplasmic reticulum membrane 0007165:signal transduction 0007050:cell cycle arrest 0007166:cell surface receptor signaling pathway 0044877:protein-containing complex binding 0032729:positive regulation of interferon-gamma production 0043410:positive regulation of MAPK cascade 0035900:response to isolation stress 0008285:negative regulation of cell population proliferation 0000139:Golgi membrane 0000165:MAPK cascade 0005525:GTP binding 0042088:T-helper 1 type immune response 0042832:defense response to protozoan 0030335:positive regulation of cell migration 0003924:GTPase activity 0098696:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane 0070374:positive regulation of ERK1 and ERK2 cascade 0010863:positive regulation of phospholipase C activity 0071480:cellular response to gamma radiation 0007265:Ras protein signal transduction 0045740:positive regulation of DNA replication 0043547:positive regulation of GTPase activity 0005794:Golgi apparatus 0005886:plasma membrane 0001889:liver development 0090314:positive regulation of protein targeting to membrane 2000630:positive regulation of miRNA metabolic process 2000251:positive regulation of actin cytoskeleton reorganization 0008284:positive regulation of cell population proliferation 0006935:chemotaxis 0006897:endocytosis 0046579:positive regulation of Ras protein signal transduction 0005737:cytoplasm 0048471:perinuclear region of cytoplasm
PDB	2X1V ; 721P ; 4DST ; 2C5L ; 4URX ; 6ZJ0 ; 1ZW6 ; 6AMB ; 4DLV ; 2CL0 ; 1JAH ; 1GNQ ; 4DSU ; 5X9S ; 1PLK ; 1NVV ; 821P ; 5WPL ; 2LWI ; 3KKN ; 1GNP ; 1CLU ; 3KKM ; 1XJ0 ; 6DZH ; 6E6P ; 6V9O ; 6BVI ; 1AGP ; 5WDQ ; 1P2V ; 3K9L ; 1CRQ ; 4DLR ; 1PLJ ; 5WFO ; 4US0 ; 6AXG ; 1JAI ; 1CTQ ; 5P21 ; 5ZC6 ; 6D5L ; 1WQ1 ; 1RVD ; 1CRR ; 3RS0 ; 6CUR ; 5WFP ; 3RRY ; 5E95 ; 1IAQ ; 3OIU ; 4XVQ ; 121P ; 5VBZ ; 6D5M ; 1ZVQ ; 2RGD ; 4US2 ; 3RSO ; 2CE2 ; 3OIV ; 3RS3 ; 2N46 ; 421P ; 2RGA ; 6CUP ; 1PLL ; 4URY ; 6D5G ; 1P2T ; 3RSL ; 4EFL ; 3RS4 ; 2RGC ; 3LO5 ; 6MQT ; 6NTD ; 2RGE ; 4DLS ; 4RSG ; 6V9N ; 3K9N ; 4L9S ; 6Q21 ; 7JHP ; 6V9F ; 1HE8 ; 2RGB ; 5VBE ; 3LBN ; 5WFR ; 4G0N ; 5B30 ; 3RS2 ; 6V9J ; 2EVW ; 6V9L ; 3I3S ; 3L8Y ; 4K81 ; 2QUZ ; 1K8R ; 1LF5 ; 1QRA ; 1AA9 ; 4URV ; 6D5V ; 1IOZ ; 2VH5 ; 521P ; 6BVM ; 6D5W ; 1NVX ; 1LF0 ; 3OIW ; 5WDO ; 3LBH ; 1NVW ; 2N42 ; 1Q21 ; 4URU ; 4L9W ; 5WFQ ; 1XD2 ; 2CLD ; 4DLU ; 6D5H ; 2CLC ; 6D56 ; 2Q21 ; 2UZI ; 4DLY ; 3RS7 ; 2RGG ; 3LBI ; 4URW ; 6D55 ; 3RS5 ; 4NYI ; 6BVK ; 1XCM ; 3TGP ; 6CUO ; 221P ; 5B2Z ; 4DLZ ; 621P ; 4US1 ; 6BVL ; 6D59 ; 4XVR ; 3L8Z ; 1P2U ; 6V9M ; 3DDC ; 1BKD ; 3RRZ ; 6ZL3 ; 4DLT ; 4EFN ; 6V94 ; 1NVU ; 6BVJ ; 2CL7 ; 2LCF ; 4NYJ ; 1CRP ; 2GDP ; 4G3X ; 2CL6 ; 1LFD ; 3KUD ; 4NYM ; 6D5E ; 3K8Y ; 6E6C ; 4EFM ; 6D5J ; 4URZ ; 4Q21 ; 4DLX ; 4DLW ; 6NTC ; 1GNR ; 1P2S ; 5WDP
Drugbank	DB03226 ; DB04137 ; DB04315 ; DB02210 ; DB08751
KEGG	hsa:3265

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 1)