HIT-result

Target Description

Type	Detail
Target ID	T34U48
Protein Name	A disintegrin and metalloproteinase with thrombospondin motifs 5
Uniprot ID	Q9UNA0
Protein Name Alias	ADAM-TS 5; ADAM-TS5; ADAMTS-5; EC 3.4.24.-; A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2
Gene ID	11096
Gene Symbol	ADAMTS5
Gene Alias	ADAMTS11; ADMP2
TTD	T98896: Clinical Trial target
Pfam	PF05986 ; PF17771 ; PF01421 ; PF00090 ; PF01562
GO	0044691:tooth eruption 0004175:endopeptidase activity 0005788:endoplasmic reticulum lumen 0042742:defense response to bacterium 0004222:metalloendopeptidase activity 0062023:collagen-containing extracellular matrix 0008201:heparin binding 0006508:proteolysis 0050840:extracellular matrix binding 0008237:metallopeptidase activity 0005576:extracellular region 0031012:extracellular matrix 0008270:zinc ion binding 0005615:extracellular space 0005178:integrin binding 0008233:peptidase activity 0120163:negative regulation of cold-induced thermogenesis 0007520:myoblast fusion 0030198:extracellular matrix organization 0022617:extracellular matrix disassembly
PDB	3LJT ; 2RJQ ; 3HY9 ; 3HY7 ; 3B8Z ; 3HYG
Drugbank	DB06945 ; DB06837 ; DB03880
KEGG	hsa:11096

Type

Detail

Target ID

T34U48

Protein Name

A disintegrin and metalloproteinase with thrombospondin motifs 5

Uniprot ID

Q9UNA0

Protein Name Alias

ADAM-TS 5; ADAM-TS5; ADAMTS-5; EC 3.4.24.-; A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2

Gene ID

11096

Gene Symbol

ADAMTS5

Gene Alias

ADAMTS11; ADMP2

TTD

T98896: Clinical Trial target

Pfam

PF05986 ; PF17771 ; PF01421 ; PF00090 ; PF01562

0044691:tooth eruption

0004175:endopeptidase activity

0005788:endoplasmic reticulum lumen

0042742:defense response to bacterium

0004222:metalloendopeptidase activity

0062023:collagen-containing extracellular matrix

0008201:heparin binding

0006508:proteolysis

0050840:extracellular matrix binding

0008237:metallopeptidase activity

0005576:extracellular region

0031012:extracellular matrix

0008270:zinc ion binding

0005615:extracellular space

0005178:integrin binding

0008233:peptidase activity

0120163:negative regulation of cold-induced thermogenesis

0007520:myoblast fusion

0030198:extracellular matrix organization

0022617:extracellular matrix disassembly

PDB

3LJT ; 2RJQ ; 3HY9 ; 3HY7 ; 3B8Z ; 3HYG

Drugbank

DB06945 ; DB06837 ; DB03880

KEGG

hsa:11096

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H0965	Deng Zhan Xi Xin	灯盏细辛	Shortscape fleabane	Erigeron breviscapus
H0026	Jiang	姜	Soybean paste	Glycine max
H1007	Dou You	豆油	Soybean oil	Glycine max
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0060	Jin Si Ku Lian	金丝苦楝	NA	Cardiospermum halicacabum
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0614	Wu Zhao Long	五爪龙	Cairo morningglory	Ipomoea cairica
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 22)