Compound Description
| ID: C0395 | Common name: Scutellarin |
| IUPAC: (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | CAS: CAS:27740-01-8 |
| Chembl ID: CHEMBL487805 | Pubchem ID: CID:185617 |
| Formula: C21H18O12 | TCM-ID: TCMC2055 |
| Smiles: C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O)O | |
| Alias:
Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-D-;
Scutellarin; 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid; Flavone, 4',5,6,7-tetrahydroxy-, 7-β-D-glucopyranuronoside; Scutellarein 7-O-β-D-glucuronide; Scutellarein 7-O-β-glucuronide; Scutellarein 7-glucuronide; Scutellarein 7-β-D-glucuronide; Scutellarein 7-β-D-glucuronoside; Scutellarin B |
Structure:
|
Related Targets (Total: 16)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
A | 3 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
A | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
A | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
B | 1 Reference(s) |
| T85NRC | Pyruvate kinase PKM | PKM |
P14618 |
B | 1 Reference(s) |
| T20E5P | Cytochrome b-245 heavy chain | CYBB |
P04839 |
B | 1 Reference(s) |
| T17E95 | Protein kinase C gamma type | PRKCG |
P05129 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T16MRU | NACHT, LRR and PYD domains-containing protein 3 | NLRP3 |
Q96P20 |
C | 1 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
C | 1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
C | 1 Reference(s) |
| T34U48 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | ADAMTS5 |
Q9UNA0 |
C | 1 Reference(s) |
| T91D6X | Protein Wnt-3a | WNT3A |
P56704 |
C | 1 Reference(s) |
| T79BDP | Frizzled-7 | FZD7 |
O75084 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 10)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
| H0614 | Wu Zhao Long | 五爪龙 | Cairo morningglory | Ipomoea cairica |
| H0310 | Pian Qin | 片芩 | Scutellaria amoena | Scutellaria baicalensis |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H1253 | Huang Qin Jin Gao Fen | 黄芩浸膏粉 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0965 | Deng Zhan Xi Xin | 灯盏细辛 | Shortscape fleabane | Erigeron breviscapus |
| H1254 | Huang Qin Tan | 黄芩炭 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1252 | Huang Qin Jin Gao | 黄芩浸膏 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
Ckey description of the interaction between compound and target