HIT-result

Type	Detail
Target ID	T39NFM
Protein Name	Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Uniprot ID	Q13627
Protein Name Alias	EC 2.7.12.1; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB
Gene ID	1859
Gene Symbol	DYRK1A
Gene Alias	DYRK; MNB; MNBH
TTD	T92803: Patented target
Pfam	PF00069
GO	0005634:nucleus 0034205:amyloid-beta formation 0106311:protein threonine kinase activity 0036289:peptidyl-serine autophosphorylation 0007623:circadian rhythm 0030425:dendrite 0018108:peptidyl-tyrosine phosphorylation 0004672:protein kinase activity 0018107:peptidyl-threonine phosphorylation 0007399:nervous system development 0004712:protein serine/threonine/tyrosine kinase activity 0043518:negative regulation of DNA damage response, signal transduction by p53 class mediator 1990904:ribonucleoprotein complex 0000381:regulation of alternative mRNA splicing, via spliceosome 0005856:cytoskeleton 0042802:identical protein binding 0016607:nuclear speck 0005654:nucleoplasm 0045893:positive regulation of transcription, DNA-templated 0106310:protein serine kinase activity 0004713:protein tyrosine kinase activity 0004715:non-membrane spanning protein tyrosine kinase activity 0006468:protein phosphorylation 0004714:transmembrane receptor protein tyrosine kinase activity 0005524:ATP binding 0015631:tubulin binding 0050321:tau-protein kinase activity 0031115:negative regulation of microtubule polymerization 0043621:protein self-association 0048156:tau protein binding 0004674:protein serine/threonine kinase activity 0003713:transcription coactivator activity 0038083:peptidyl-tyrosine autophosphorylation 0018105:peptidyl-serine phosphorylation 0046777:protein autophosphorylation 0033120:positive regulation of RNA splicing 0030424:axon 0090312:positive regulation of protein deacetylation 0005737:cytoplasm 0003779:actin binding 0008092:cytoskeletal protein binding 0048025:negative regulation of mRNA splicing, via spliceosome 0016032:viral process
PDB	6EIR ; 6QU2 ; 4MQ2 ; 6S14 ; 6S1B ; 4NCT ; 2WO6 ; 5A4E ; 4YLK ; 6S1I ; 5A4L ; 6S1J ; 6S17 ; 6UIP ; 6EIF ; 4YLL ; 6T6A ; 6EIJ ; 6S1H ; 6EIL ; 6EIP ; 5A4Q ; 3ANQ ; 6EJ4 ; 3ANR ; 6S11 ; 5A4T ; 2VX3 ; 6EIQ ; 5AIK ; 6EIS ; 6A1F ; 4MQ1 ; 6EIV ; 6A1G ; 4YU2 ; 4YLJ ; 6UWY ; 5A3X ; 5A54 ; 4AZE
Drugbank	DB12010 ; DB07608
KEGG	hsa:1859

Go to browser

Name: Harmine

Go to browser

Name: Alcohol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1121	Bai Ji Li	白蒺藜	Tribulus fruit	Tribulus terrestris
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0904	Ci Ji Li	刺蒺藜	Puncturevine caltrap	Tribulus terrestris
H0011	Ji Li	蒺藜	Puncturevine caltrop fruit	Tribulus terrestris
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0416	Shan Shen	山参	NA	Panax ginseng
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens