HIT-result

Type	Detail
Target ID	T42WKC
Protein Name	Ephrin type-A receptor 4
Uniprot ID	P54764
Protein Name Alias	EC 2.7.10.1; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
Gene ID	2043
Gene Symbol	EPHA4
Gene Alias	HEK8; SEK; TYRO1
TTD	T70234: Research target
Pfam	PF14575 ; PF07647 ; PF00041 ; PF07714 ; PF01404
GO	0008347:glial cell migration 0042802:identical protein binding 0043235:receptor complex 0007275:multicellular organism development 0046777:protein autophosphorylation 0007155:cell adhesion 0030425:dendrite 0018108:peptidyl-tyrosine phosphorylation 0004672:protein kinase activity 1903051:negative regulation of proteolysis involved in cellular protein catabolic process 0001540:amyloid-beta binding 1902961:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 0097485:neuron projection guidance 0046875:ephrin receptor binding 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0098978:glutamatergic synapse 0061001:regulation of dendritic spine morphogenesis 0044295:axonal growth cone 2001108:positive regulation of Rho guanyl-nucleotide exchange factor activity 0009986:cell surface 0007628:adult walking behavior 0043087:regulation of GTPase activity 0098883:synapse pruning 0043507:positive regulation of JUN kinase activity 0048710:regulation of astrocyte differentiation 0016301:kinase activity 0106030:neuron projection fasciculation 0097161:DH domain binding 0005737:cytoplasm 0099055:integral component of postsynaptic membrane 0030175:filopodium 0008045:motor neuron axon guidance 1905244:regulation of modification of synaptic structure 0005887:integral component of plasma membrane 0043005:neuron projection 1990782:protein tyrosine kinase binding 0005783:endoplasmic reticulum 0005524:ATP binding 0005886:plasma membrane 0005912:adherens junction 0098685:Schaffer collateral - CA1 synapse 0005741:mitochondrial outer membrane 0048013:ephrin receptor signaling pathway 0072178:nephric duct morphogenesis 0043204:perikaryon 1900272:negative regulation of long-term synaptic potentiation 0050821:protein stabilization 0050770:regulation of axonogenesis 0034332:adherens junction organization 0098839:postsynaptic density membrane 0005004:GPI-linked ephrin receptor activity 0031901:early endosome membrane 0021957:corticospinal tract morphogenesis 0099056:integral component of presynaptic membrane 0097155:fasciculation of sensory neuron axon 0005794:Golgi apparatus 1904646:cellular response to amyloid-beta 0050775:positive regulation of dendrite morphogenesis 0043197:dendritic spine 0004714:transmembrane receptor protein tyrosine kinase activity 0061098:positive regulation of protein tyrosine kinase activity 0010977:negative regulation of neuron projection development 0033674:positive regulation of kinase activity 0030424:axon 0031594:neuromuscular junction 0043198:dendritic shaft 0042731:PH domain binding 0005005:transmembrane-ephrin receptor activity 0048681:negative regulation of axon regeneration 0007411:axon guidance 1902004:positive regulation of amyloid-beta formation 0043679:axon terminus 0097156:fasciculation of motor neuron axon 0090102:cochlea development
PDB	4W50 ; 3CKH ; 2WO3 ; 2WO2 ; 3GXU ; 4BK5 ; 2LW8 ; 4BK4 ; 4BKF ; 2WO1 ; 4BKA ; 5JR2 ; 4W4Z ; 4M4R ; 4M4P
Drugbank	DB12010
KEGG	hsa:2043

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Name: Rhynchophylline

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1099	Gou Teng	钩藤	Sharpleaf gambirplant	Uncaria rhynchophylla