HIT-result

Type	Detail
Target ID	T53U89
Protein Name	Runt-related transcription factor 1
Uniprot ID	Q01196
Protein Name Alias	Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit
Gene ID	861
Gene Symbol	RUNX1
Gene Alias	AML1; CBFA2
TTD	T43711: Research target
Pfam	PF00853 ; PF08504
GO	0000976:transcription regulatory region sequence-specific DNA binding 0030097:hemopoiesis 0048935:peripheral nervous system neuron development 0010629:negative regulation of gene expression 0060043:regulation of cardiac muscle cell proliferation 0005524:ATP binding 0043371:negative regulation of CD4-positive, alpha-beta T cell differentiation 0043378:positive regulation of CD8-positive, alpha-beta T cell differentiation 0016513:core-binding factor complex 0008134:transcription factor binding 0001959:regulation of cytokine-mediated signaling pathway 0045637:regulation of myeloid cell differentiation 0010755:regulation of plasminogen activation 0030111:regulation of Wnt signaling pathway 0045589:regulation of regulatory T cell differentiation 0030182:neuron differentiation 0046982:protein heterodimerization activity 0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding 0032743:positive regulation of interleukin-2 production 1905203:regulation of connective tissue replacement 0002062:chondrocyte differentiation 0033146:regulation of intracellular estrogen receptor signaling pathway 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0005654:nucleoplasm 0003677:DNA binding 0045893:positive regulation of transcription, DNA-templated 0045595:regulation of cell differentiation 0000785:chromatin 0003700:DNA-binding transcription factor activity 0071425:hematopoietic stem cell proliferation 0045944:positive regulation of transcription by RNA polymerase II 0042803:protein homodimerization activity 0045766:positive regulation of angiogenesis 0005634:nucleus 1902036:regulation of hematopoietic stem cell differentiation 0032967:positive regulation of collagen biosynthetic process 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0061026:cardiac muscle tissue regeneration 0005509:calcium ion binding 0030099:myeloid cell differentiation 0001503:ossification 1903055:positive regulation of extracellular matrix organization 0050855:regulation of B cell receptor signaling pathway 2000810:regulation of bicellular tight junction assembly 0045616:regulation of keratinocyte differentiation 0043231:intracellular membrane-bounded organelle 0030853:negative regulation of granulocyte differentiation 0000122:negative regulation of transcription by RNA polymerase II 0030854:positive regulation of granulocyte differentiation 0045652:regulation of megakaryocyte differentiation 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0002573:myeloid leukocyte differentiation 0006357:regulation of transcription by RNA polymerase II
PDB	1CO1 ; 1LJM ; 1CMO ; 1E50 ; 1H9D
Drugbank	NA
KEGG	hsa:861

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Name: Β-Cryptoxanthin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense