HIT-result

Type	Detail
Target ID	T61HJT
Protein Name	Histone-lysine N-methyltransferase EZH2
Uniprot ID	Q15910
Protein Name Alias	EC 2.1.1.356; ENX-1; Enhancer of zeste homolog 2; Lysine N-methyltransferase 6
Gene ID	2146
Gene Symbol	EZH2
Gene Alias	KMT6
TTD	T25265: Successful target
Pfam	PF00856 ; PF18118 ; PF18264 ; PF11616
GO	0005634:nucleus 0042054:histone methyltransferase activity 0018024:histone-lysine N-methyltransferase activity 0043547:positive regulation of GTPase activity 0070301:cellular response to hydrogen peroxide 0046976:histone methyltransferase activity (H3-K27 specific) 0034244:negative regulation of transcription elongation from RNA polymerase II promoter 0014898:cardiac muscle hypertrophy in response to stress 0070734:histone H3-K27 methylation 2000134:negative regulation of G1/S transition of mitotic cell cycle 1900006:positive regulation of dendrite development 0006355:regulation of transcription, DNA-templated 0019058:viral life cycle 0042752:regulation of circadian rhythm 0003682:chromatin binding 0048387:negative regulation of retinoic acid receptor signaling pathway 0000781:chromosome, telomeric region 0045814:negative regulation of gene expression, epigenetic 0035098:ESC/E(Z) complex 0008284:positive regulation of cell population proliferation 0098532:histone H3-K27 trimethylation 0045892:negative regulation of transcription, DNA-templated 0048468:cell development 0005677:chromatin silencing complex 0005737:cytoplasm 1904772:response to tetrachloromethane 0031490:chromatin DNA binding 0000979:RNA polymerase II core promoter sequence-specific DNA binding 0045605:negative regulation of epidermal cell differentiation 0045120:pronucleus 0003714:transcription corepressor activity 0036333:hepatocyte homeostasis 0021695:cerebellar cortex development 0030183:B cell differentiation 0006306:DNA methylation 0032355:response to estradiol 0000785:chromatin 1990841:promoter-specific chromatin binding 0014013:regulation of gliogenesis 0070878:primary miRNA binding 0001226:RNA polymerase II transcription corepressor binding 0021766:hippocampus development 0035984:cellular response to trichostatin A 1902808:positive regulation of cell cycle G1/S phase transition 0097421:liver regeneration 0048511:rhythmic process 0014834:skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration 0010718:positive regulation of epithelial to mesenchymal transition 0051154:negative regulation of striated muscle cell differentiation 0006348:chromatin silencing at telomere 0043433:negative regulation of DNA-binding transcription factor activity 0000122:negative regulation of transcription by RNA polymerase II 0043406:positive regulation of MAP kinase activity 0071902:positive regulation of protein serine/threonine kinase activity 0043021:ribonucleoprotein complex binding 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0005654:nucleoplasm 0070314:G1 to G0 transition 0071168:protein localization to chromatin 0016571:histone methylation 0070317:negative regulation of G0 to G1 transition 0006325:chromatin organization
PDB	5WUK ; 4MI5 ; 5HYN ; 5U5T ; 5U62 ; 6C24 ; 5H25 ; 5H24 ; 6C23 ; 5IJ7 ; 4MI0 ; 5IJ8 ; 6P5L ; 7AT8 ; 5H19 ; 2C6V ; 5GSA ; 5H14 ; 5LS6 ; 6U4Y ; 5H17 ; 5H15 ; 5WG6
Drugbank	DB12887 ; DB14581
KEGG	hsa:2146

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Name: S-Adenosyl Methionine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens