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Target Description
Type
Detail
Target ID
T63T5P
Protein Name
Histone deacetylase 4
Uniprot ID
P56524
Protein Name Alias
HD4; EC 3.5.1.98
Gene ID
9759
Gene Symbol
HDAC4
Gene Alias
KIAA0288
TTD
T63816: Clinical Trial target
Pfam
PF12203
;
PF00850
GO
0008134:transcription factor binding
0042802:identical protein binding
0005634:nucleus
0004407:histone deacetylase activity
0071260:cellular response to mechanical stimulus
0070491:repressing transcription factor binding
0005829:cytosol
0014898:cardiac muscle hypertrophy in response to stress
0033558:protein deacetylase activity
0000118:histone deacetylase complex
1903428:positive regulation of reactive oxygen species biosynthetic process
0014911:positive regulation of smooth muscle cell migration
0007399:nervous system development
0048742:regulation of skeletal muscle fiber development
0010882:regulation of cardiac muscle contraction by calcium ion signaling
0043525:positive regulation of neuron apoptotic process
0008284:positive regulation of cell population proliferation
0008285:negative regulation of cell population proliferation
0032041:NAD-dependent histone deacetylase activity (H3-K14 specific)
0017053:transcription repressor complex
0045892:negative regulation of transcription, DNA-templated
0043393:regulation of protein binding
0005737:cytoplasm
0031672:A band
0001085:RNA polymerase II transcription factor binding
0070555:response to interleukin-1
0042113:B cell activation
0033613:activating transcription factor binding
0019901:protein kinase binding
0003714:transcription corepressor activity
0071356:cellular response to tumor necrosis factor
0014894:response to denervation involved in regulation of muscle adaptation
0030018:Z disc
0030955:potassium ion binding
0030183:B cell differentiation
1990841:promoter-specific chromatin binding
0070933:histone H4 deacetylation
0048661:positive regulation of smooth muscle cell proliferation
0045820:negative regulation of glycolytic process
0042493:response to drug
0071374:cellular response to parathyroid hormone stimulus
0070932:histone H3 deacetylation
0006954:inflammatory response
1902894:negative regulation of pri-miRNA transcription by RNA polymerase II
0006476:protein deacetylation
0045668:negative regulation of osteoblast differentiation
0016575:histone deacetylation
0045893:positive regulation of transcription, DNA-templated
0051091:positive regulation of DNA-binding transcription factor activity
0000122:negative regulation of transcription by RNA polymerase II
0043433:negative regulation of DNA-binding transcription factor activity
0008270:zinc ion binding
0040029:regulation of gene expression, epigenetic
0033235:positive regulation of protein sumoylation
0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding
0005654:nucleoplasm
0006338:chromatin remodeling
0034983:peptidyl-lysine deacetylation
0016607:nuclear speck
0010592:positive regulation of lamellipodium assembly
0031594:neuromuscular junction
0010832:negative regulation of myotube differentiation
0002076:osteoblast development
0042641:actomyosin
0045944:positive regulation of transcription by RNA polymerase II
0001501:skeletal system development
0042826:histone deacetylase binding
1902437:positive regulation of male mating behavior
0019789:SUMO transferase activity
PDB
2O94
;
2VQQ
;
2VQJ
;
2VQO
;
3UZD
;
5ZOP
;
6FYZ
;
3V31
;
5A2S
;
2VQM
;
2VQV
;
4CBT
;
5ZOO
;
4CBY
;
2H8N
;
3UXG
;
2VQW
Drugbank
DB06176
;
DB05015
;
DB01593
;
DB14533
;
DB06603
;
DB14487
;
DB07879
;
DB08613
;
DB14548
KEGG
hsa:9759
Related Compounds (Total: 1)
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C0477
Name: Valproic Acid
Related Herbs (Total: 2)
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Herb id
Chinese Pin Yin
Chinese Character
English Name
Latin Name
H0360
Ren Zhong Bai
人中白
Human urine sediment
Homo sapiens
H0847
Zi He Che
紫河车
Human placenta
Homo sapiens