Target Description

Type Detail
Target ID T63T5P
Protein Name Histone deacetylase 4
Uniprot ID P56524
Protein Name Alias HD4;  EC 3.5.1.98
Gene ID 9759
Gene Symbol HDAC4
Gene Alias KIAA0288
TTD T63816: Clinical Trial target
Pfam PF12203 ; PF00850
GO
0008134:transcription factor binding

0042802:identical protein binding

0005634:nucleus

0004407:histone deacetylase activity

0071260:cellular response to mechanical stimulus

0070491:repressing transcription factor binding

0005829:cytosol

0014898:cardiac muscle hypertrophy in response to stress

0033558:protein deacetylase activity

0000118:histone deacetylase complex

1903428:positive regulation of reactive oxygen species biosynthetic process

0014911:positive regulation of smooth muscle cell migration

0007399:nervous system development

0048742:regulation of skeletal muscle fiber development

0010882:regulation of cardiac muscle contraction by calcium ion signaling

0043525:positive regulation of neuron apoptotic process

0008284:positive regulation of cell population proliferation

0008285:negative regulation of cell population proliferation

0032041:NAD-dependent histone deacetylase activity (H3-K14 specific)

0017053:transcription repressor complex

0045892:negative regulation of transcription, DNA-templated

0043393:regulation of protein binding

0005737:cytoplasm

0031672:A band

0001085:RNA polymerase II transcription factor binding

0070555:response to interleukin-1

0042113:B cell activation

0033613:activating transcription factor binding

0019901:protein kinase binding

0003714:transcription corepressor activity

0071356:cellular response to tumor necrosis factor

0014894:response to denervation involved in regulation of muscle adaptation

0030018:Z disc

0030955:potassium ion binding

0030183:B cell differentiation

1990841:promoter-specific chromatin binding

0070933:histone H4 deacetylation

0048661:positive regulation of smooth muscle cell proliferation

0045820:negative regulation of glycolytic process

0042493:response to drug

0071374:cellular response to parathyroid hormone stimulus

0070932:histone H3 deacetylation

0006954:inflammatory response

1902894:negative regulation of pri-miRNA transcription by RNA polymerase II

0006476:protein deacetylation

0045668:negative regulation of osteoblast differentiation

0016575:histone deacetylation

0045893:positive regulation of transcription, DNA-templated

0051091:positive regulation of DNA-binding transcription factor activity

0000122:negative regulation of transcription by RNA polymerase II

0043433:negative regulation of DNA-binding transcription factor activity

0008270:zinc ion binding

0040029:regulation of gene expression, epigenetic

0033235:positive regulation of protein sumoylation

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0005654:nucleoplasm

0006338:chromatin remodeling

0034983:peptidyl-lysine deacetylation

0016607:nuclear speck

0010592:positive regulation of lamellipodium assembly

0031594:neuromuscular junction

0010832:negative regulation of myotube differentiation

0002076:osteoblast development

0042641:actomyosin

0045944:positive regulation of transcription by RNA polymerase II

0001501:skeletal system development

0042826:histone deacetylase binding

1902437:positive regulation of male mating behavior

0019789:SUMO transferase activity

PDB 2O94 ; 2VQQ ; 2VQJ ; 2VQO ; 3UZD ; 5ZOP ; 6FYZ ; 3V31 ; 5A2S ; 2VQM ; 2VQV ; 4CBT ; 5ZOO ; 4CBY ; 2H8N ; 3UXG ; 2VQW
Drugbank DB06176 ; DB05015 ; DB01593 ; DB14533 ; DB06603 ; DB14487 ; DB07879 ; DB08613 ; DB14548
KEGG hsa:9759

Related Compounds  (Total: 1)

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C0477
Name: Valproic Acid


Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens