HIT-result

Type	Detail
Target ID	T65CYN
Protein Name	Solute carrier family 12 member 2
Uniprot ID	P55011
Protein Name Alias	Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Gene ID	6558
Gene Symbol	SLC12A2
Gene Alias	NKCC1
TTD	T85581: Clinical Trial target
Pfam	PF00324 ; PF08403 ; PF03522
GO	0070062:extracellular exosome 0044297:cell body 0046873:metal ion transmembrane transporter activity 0006972:hyperosmotic response 0098658:inorganic anion import across plasma membrane 0051087:chaperone binding 0150104:transport across blood-brain barrier 0016020:membrane 0008519:ammonium transmembrane transporter activity 0015377:cation:chloride symporter activity 0043025:neuronal cell body 0007214:gamma-aminobutyric acid signaling pathway 0055075:potassium ion homeostasis 0030007:cellular potassium ion homeostasis 1904464:regulation of matrix metallopeptidase secretion 0061044:negative regulation of vascular wound healing 0015079:potassium ion transmembrane transporter activity 0005829:cytosol 0150003:regulation of spontaneous synaptic transmission 0030321:transepithelial chloride transport 0006883:cellular sodium ion homeostasis 0006811:ion transport 0045795:positive regulation of cell volume 0070634:transepithelial ammonium transport 0005886:plasma membrane 0030659:cytoplasmic vesicle membrane 0043005:neuron projection 0055078:sodium ion homeostasis 0005887:integral component of plasma membrane 0098659:inorganic cation import across plasma membrane 1904450:positive regulation of aspartate secretion 1902476:chloride transmembrane transport 1990573:potassium ion import across plasma membrane 0042995:cell projection 1990869:cellular response to chemokine 0035633:maintenance of blood-brain barrier 0044298:cell body membrane 0019901:protein kinase binding 0098719:sodium ion import across plasma membrane 0035725:sodium ion transmembrane transport 0051879:Hsp90 protein binding 0015379:potassium:chloride symporter activity 0009925:basal plasma membrane 0008511:sodium:potassium:chloride symporter activity 0006884:cell volume homeostasis 0055064:chloride ion homeostasis 0010818:T cell chemotaxis 0031253:cell projection membrane 0015696:ammonium transport 0035865:cellular response to potassium ion 0030644:cellular chloride ion homeostasis 0071944:cell periphery 0007568:aging 0016328:lateral plasma membrane 0016324:apical plasma membrane 1903561:extracellular vesicle
PDB	6PZT
Drugbank	DB01325 ; DB11098 ; DB00214 ; DB00887 ; DB00761
KEGG	hsa:6558

Go to browser

Name: Raffinose

Go to browser

Name: gamma-aminobutyric acid

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0783	Ze Lan	泽兰	Shiny bugleweed	Lycopi Herba
H0972	Di Huang	地黄	Rehmanniae	Rehmannia glutinosa
H0713	Che Qian Cao	车前草	all-grass of rippleseed plantain	Plantago depressa
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0549	Tian Zhu Huang	天竺黄	Chinese schinzostachyum tabasheer	Concretio silicea bambusae