HIT-result

Type	Detail
Target ID	T65R2B
Protein Name	Rap guanine nucleotide exchange factor 3
Uniprot ID	O95398
Protein Name Alias	Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI
Gene ID	10411
Gene Symbol	RAPGEF3
Gene Alias	CGEF1; EPAC; EPAC1
TTD	T52489: Clinical Trial target
Pfam	PF00027 ; PF00610 ; PF00617 ; PF00618
GO	0060143:positive regulation of syncytium formation by plasma membrane fusion 0019904:protein domain specific binding 0043547:positive regulation of GTPase activity 0045766:positive regulation of angiogenesis 0061028:establishment of endothelial barrier 0005902:microvillus 2000249:regulation of actin cytoskeleton reorganization 0002250:adaptive immune response 0012505:endomembrane system 0051496:positive regulation of stress fiber assembly 0016020:membrane 0070062:extracellular exosome 0033138:positive regulation of peptidyl-serine phosphorylation 0046827:positive regulation of protein export from nucleus 1901985:positive regulation of protein acetylation 0050796:regulation of insulin secretion 0030552:cAMP binding 0005085:guanyl-nucleotide exchange factor activity 0032486:Rap protein signal transduction 0005886:plasma membrane 0030027:lamellipodium 0030175:filopodium 0071320:cellular response to cAMP 0019933:cAMP-mediated signaling 0007165:signal transduction 0034242:negative regulation of syncytium formation by plasma membrane fusion 0001525:angiogenesis
PDB	6H7E
Drugbank	NA
KEGG	hsa:10411

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 1)