HIT-result

Type	Detail
Target ID	T67NYW
Protein Name	Protein phosphatase 1A
Uniprot ID	P35813
Protein Name Alias	EC 3.1.3.16; Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IA
Gene ID	5494
Gene Symbol	PPM1A
Gene Alias	PPPM1A
TTD	T55260: Clinical Trial target
Pfam	PF07830 ; PF00481
GO	0005634:nucleus 0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling 0007050:cell cycle arrest 0046827:positive regulation of protein export from nucleus 0010991:negative regulation of SMAD protein complex assembly 0004722:protein serine/threonine phosphatase activity 0006470:protein dephosphorylation 0106307:protein threonine phosphatase activity 0071560:cellular response to transforming growth factor beta stimulus 0106306:protein serine phosphatase activity 0006499:N-terminal protein myristoylation 0005829:cytosol 1901223:negative regulation of NIK/NF-kappaB signaling 0000287:magnesium ion binding 0005886:plasma membrane 0033192:calmodulin-dependent protein phosphatase activity 0035970:peptidyl-threonine dephosphorylation 0030514:negative regulation of BMP signaling pathway 0030145:manganese ion binding 0016020:membrane 0030512:negative regulation of transforming growth factor beta receptor signaling pathway 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0070412:R-SMAD binding 0045893:positive regulation of transcription, DNA-templated 0000122:negative regulation of transcription by RNA polymerase II 0005654:nucleoplasm 0090263:positive regulation of canonical Wnt signaling pathway 0016311:dephosphorylation
PDB	3FXJ ; 6B67 ; 1A6Q ; 3FXM ; 4RA2 ; 4RAF ; 3FXK ; 4RAG ; 3FXO ; 3FXL
Drugbank	NA
KEGG	hsa:5494

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Name: Simvastatin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens